VERA DEMARCHI AIELLO
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
24 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 24
- PEDIATRIC HEART TRANSPLANTATION PROGRAM: SINGLE CENTER EXPERIENCE OF 20 YEARS(2013) AZEKA, Estela; GALAS, Filomena; TANAMATI, Carla; PENHA, Juliano; FERNANDES, Marcos; SENAHA, Luciano; XAVIER, Johnny; DELGADO, Ana Beatriz Romani; KAJITA, Luiz; AIELLO, Vera; BENVENUTI, Luiz; MIURA, Nana; AULER JUNIOR, Jose Otavio Costa; JATENE, MarceloOBJECTIVE: Heart transplantation has been the treatment of choice for children with refractory to conventional therapy. To report the experience with heart transplantation in a single center. MATERIAL AND METHODS: To report the single center experience of hearttransplantation. Data analysis was demographic characteristics, clinical outcome and survival Kaplan Meier curve. RESULTS: From October 30, 1992 to October 2nd, 2012, 120 transplants were performed and 115 patients were submitted to heart transplantation at Heart Institute (InCor) University of Sao Paulo Medical School, Sao Paulo, Brazil. The causes of indication for transplantation were: cardiomyopathies (76%) and congenital heart disease (24%). Five patients were submitted to re-transplantation. Three of them were re-transplanted on the early postoperative period with high mortality (66.6%). One patient was submitted to simultaneous re-transplantation and kidney transplantation after 13.9 yrs of follow-up and one of patient was successful re-transplanted after 10 yr of follow-up. The post-operative immunosuppression regimen was double immunosuppression and polyclonal anti-thymocyte serum induction therapy. The actuarial survival was 80%, 71%, and 61% at 1, 5, and 10 yr, respectively. CONCLUSION: Heart transplantation has been a promising option for children. The use of double immunosuppression with polyclonal anti-thymocyte serum induction therapy combined with surveillance of acute rejection with non-invasive tests may provide favorable clinical outcome.
conferenceObject Mechanical Esophageal Displacement for Esophageal Safety of Mechanical Esophageal Displacement for Esophageal Thermal Injury Prevention During Atrial Fibrillation Ablation in Swine(2019) PEREIRA, Renner; PISANI, Cristiano F.; AIELLO, Vera; CESTARI, Idagene A.; MOURA, Daniel; CHOKR, Muhieddine; HARDY, Carina; SISSY, Melo; SCANAVACCA, Mauricio; HACHUL, DeniseconferenceObject Hypercholesterolemic diet worst left ventricular function evaluated by echocardiography in rats subjected to an experimental infarct model(2012) DOURADO, Paulo M.; TSUTSUI, Jeane M.; CASELLA FILHO, Antonio; LANDIM, Mauricio B.; GALVAO, Tatiana F.; AIELLO, Vera D.; LUZ, Protasio Da; MATHIAS JR., Wilson; CHAGAS, Antonio C.Introduction: A better comprehension of the hypercholesterolemic diet role in the set of acute myocardial infarct is fundamental. Objectives: Evaluation of the role of hypercholesterolemic diet in the determination of the hemodynamics patterns by echocardiography. Methods: Sixty three anesthetized rats were subjected to occlusion of the left anterior descending (LAD) coronary artery and divided in six groups: G1–just normal diet (ND); G2–ND and treatment with rosuvastatim for 30 days began after infarct and G3–ND and 30 days previously to infarct treated with rosuvastatim until 30 days after it; G4 –just hypercholesterolemic diet (HD); G5–HD and treatment with rosuvastatim for 30 days began after infarct and G6 –HD and 30 days previously to infarct treated with rosuvastatim until 30 days after it. Echocardiography was performed using bidimensional image in the paraesternal long axis. The planimetry of the left ventricle areas in the end of the diastole (LVEDA) and systole (LVESA) were realized before the infarct (pre) and 30 days after the infarct (post) . A p value<0.05 was considered significant. Conclusion: The hypercholesterolemic diet worst the hemodynamics parameters–LVEDA and LVESA - in comparison with the normocholesterolemic group treated with rosuvastatim.conferenceObject RESTRICTIVE AND HYPERTROPHIC CARDIOMYOPATHIES AS INDICATION FOR HEART TRANSPLANTATION: CLINICAL OUTCOME IN A SINGLE CENTER(2013) TANAKA, Ana Cristina; MIURA, Nana; THOMAZ, Ana Maria; AIELLO, Vera Demarchi; BENEVENUTI, Luiz; TAVARES, Glaucia; NOMURA, Cesar; JATENE, Marcelo Biscegli; AZEKA, EstelaPURPOSE: The purpose of this study was evaluate the prevalence and outcome of restrictive and hypertrophic cardiomyopathies in a cohort of pediatric heart transplantation. METHOD: To evaluate the prevalence and clinical outcome of children with restrictive and hypertrophic cardiomyopathies submitted heart transplantation. RESULTS: From october 1992 to 2012, 115 patients were submitted heart transplantation. 120 transplants were performed at Heart Institute (InCor) University São Paulo Medical School. Seventeen (14,7%) of these patients hat restrictive cardiomyopathy/hypertrophic cardiomyopathy and have undergone to heart transplantation. The mean age was 10,4 years. Survival was 76,4%. Follow-up period ranged from 26 days to 6,6 years. CONCLUSION: Restrictive and hypertrophic cardiomyopathies can be an indication for heart transplantation a favorable outcome.conferenceObject CLINICAL CHALLENGES AFTER PEDIATRIC HEART TRANSPLANTATION: 20 YEARS OF EXPERIENCE(2013) AZEKA, Estela; AULER, Jose Otavio; GALAS, Filomena; TANAMATI, Carla; PENHA, Juliano; KAJITA, Luiz; AIELLO, Vera; BENVENUTI, Luiz; JATENE, MarceloPURPOSE: Heart transplantation has been the treatment of choice for children with refractory to conventional therapy. Objective: to report the clinical experience with heart transplantation in a single center. METHOD: To report the single center experience of heart transplantation. Data analysis was demographic characteristics, clinical outcome and survival Kaplan Meier curve. RESULTS: From October 30, 1992 to October 2nd, 2012, 120 transplants were performed and 115 patients were submitted to heart transplantation at Heart Institute (InCor) University of Sao Paulo Medical School, Sao Paulo, Brazil. The causes of indication for transplantation were: cardiomyopathies (76%) and congenital heart disease (24%). Five patients were submitted to re-transplantation. Three of them were re-transplanted on the early postoperative period with high mortality (66.6%). One patient was submitted to simultaneous re-transplantation and kidney transplantation after 13.9 years of follow-up and one of patient was successful re-transplanted after 10 year of follow-up. The post-operative immunosuppression regimen was double immunosuppression and polyclonal anti-thymocyte serum induction therapy. The actuarial survival was 80%, 71%, and 61% at 1, 5, and 10 yr, respectively. CONCLUSION: Heart transplantation has been a promising option for children. The use of double immunosuppression with polyclonal anti-thymocyte serum induction therapy combined with surveillance of acute rejection with non-invasive tests may provide favorable clinical outcome.conferenceObject Histomorphometric evaluation of the arterial valve in Persistent Common Arterial trunk its and possible relation to coronary and aortic arch abnormalities(2012) AIELLO, V. D.; LIGUORI, G. R.; JATENE, M. B.Introduction: Hearts with common arterial trunk (CAT) may show dysplastic arterial valve, which appear to impact on early deaths and on the postoperative prognosis. The morphology of dysplastic leaflets is still poorly defined and usually described qualitatively in the literature as nonspecific fibrous thickening of their margins. Abnormalities of the coronary arteries and of the aortic arch arteries have also been described in CAT, but to date no study has sought to establish objective relations between the truncal valve abnormalities and other morphological features. OBJECTIVE: Systematically assess, both qualitatively and quantitatively, alterations of the truncal valve and check for possible associations with coronary and aortic arch anomalies. Methods: Thirteen heart specimens with CAT were analyzed. Gross features of the coronary ostia (number, position and shape) and aortic arch were annotated. The thickest semilunar leaflet was sampled for histological analysis. Linear measurements were obtained: proximal, medial and distal thicknesses, length and total area of the leaflet. Results: The thickest valvar segments were the medial and distal ones. There was a negative correlation between the distal thickness of the leaflet and the linear distance from the coronary ostium to the valvar commissure (R2 = 0.448; P = 0.024 and R2 = 0.697; P = 0.001, respectively for the left and right coronary ostia). The groups with patent arterial duct and abnormal subclavian artery presented greater medial (P = 0.048; P = 0.044) and distal (P = 0.013; P = 0.028) thickness of the semilunar leaflet. Conclusion: Anomalies of the position (juxtacommissural origin) of the coronary ostia and aortic arch abnormalities are related to the dysplasia of the truncal valve.conferenceObject HYPERCHOLESTEROLEMIC DIET WORST LEFT VENTRICULAR FUNCTION DESPITE REDUCTION OF MMP-2 EVALUATED BY ECHOCARDIOGRAPHY IN AN EXPERIMENTAL RAT INFARCT MODEL(2014) DOURADO, P.; LANDIM, M. B. P.; CASELLA FILHO, A.; TSUTSUI, J. M.; ROEVER, L.; AIELLO, V. D.; MATHIAS JR., W.; LUZ, P. da; CHAGAS, A. C. P.conferenceObject Pulmonary pathological findings in autopsies of sickle cell disease in Brazil(2013) RASSE, German; HENCKLAIN, Guilherme; MENOSI, Sandra; DEMARCHI, Vera; SOUZA, Rogerio; MAUAD, ThaisconferenceObject SIBLINGS WITH RESTRICTIVE SYNDROME AND HYPERTROPHIC CARDIOMYOPATHY: A RARE CASE OF SUCCESSFUL HEART TRANSPLANTATION(2013) AZEKA, Estela; KAWASAKA, Ana Laura B. C.; TANAKA, Ana Cristina S.; PEREIRA, Alexandre C.; AIELLO, Vera D.; JATENE, Marcelo B.PURPOSE: To report the cases of siblings with restrictive syndrome who underwent heart transplantation and whose hearts had histological characteristics of hypertrophic cardiomyopathy (HCM). METHOD: Case1) A 7 year-old boy with recurrent pneumonias and cardiomegaly. Echocardiography showed features of restrictive cardiomyopathy. No pericardial commitment was found. Due to refractory congestive heart failure he was listed and successfully transplanted at the age 14. The analysis of the explanted heart revealed diffuse myocite disarray, with no septal asymmetry or subaortic obstruction. He is currently in clinical follow up for 5 years. Case 2) A 10 year-old female with exertion dyspnea, cyanosis and vomits. Due to the family history, she was referred for investigation. Restrictive cardiomyopathy was diagnosed. She was listed for heart transplant and successfully transplanted at the age of 13. The analysis of the explanted heart showed mild thickening of ventricular walls with no asymmetries or subaortic obstruction and several areas of myocyte disarray and fibrosis. She is currently in clinical follow up for 2 years. Blood samples of our patients were tested for mutations in genes MYH7, MYBPC and Troponin I (most frequently related to HCM in Brazil), but no alterations were found. CONCLUSION: HCM is a genetic condition related to mutations in genes that encode components of the sarcomere. It can rarely present with features of restrictive syndrome. Heart transplant is the therapeutic option for refractory congestive heart failure, before the evolution to pulmonary hypertension, with good clinical outcome.conferenceObject Articular Cartilage Repair By Tissue Engineering And Cell Therapy: A Pre-clinical Trialimaging Evaluation(2022) SANTANNA, J. P.; FARIA, R. R.; PINHEIRO, C. C.; AIELLO, V. D.; FERNANDES, T. L.; BUENO, D. F.; HERNANDEZ, A. J.
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