LUCILA DE CAMPOS
Projetos de Pesquisa
Unidades Organizacionais
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina
2 resultados
Resultados de Busca
Agora exibindo 1 - 2 de 2
conferenceObject Midazolam is a major cause of intraoperative immediate hypersensitivity reactions(2018) D'ONOFRIO, Ana Carolina; BORALLI, Cristiane Fernandes; PORTILHO, Nathalia Coelho; GARRO, Laila Sabino; RIBEIRO, Marisa Rosimeire; MAGALHAES, Manoela Crespo De; CAMPOS, Lucila; MOTTA, Antonio Abilio; KALIL FILHO, Jorge Elias; GIAVINA-BIANCHI, Pedro; AUN, Marcelo V.- BAT in the Diagnosis of Drug Allergy: a Novel Tool in Clinical Daily Practice?(2019) CAMPOS, Lucila; GALVAO, Violeta Regnier; KALIL, Jorge; CASTELLS, Mariana; GIAVINA-BIANCHI, PedroPurpose of ReviewThe aim of this study is to critically review the relevant literature published on basophil activation test, presenting the current knowledge and future perspectives.Recent FindingsBasophil activation test (BAT) results varied accordingly to the class of the drug studied, and have promising results in immediate hypersensitivity reactions to pyrazolone (selective reactors), neuromuscular blockers, beta-lactams, and platinum compounds, all examples of classical IgE-mediated hypersensitivity drug reactions.SummaryCurrently, BAT is applied in research settings, but based in the results of our review, the test can be considered as a diagnostic tool for daily practice for selected patients and selected drugs, when the test is available, particularly for patients who experienced severe reactions and when diagnosis cannot be stablished by serum-specific IgE and skin testing, in order to avoid unnecessary drug provocations tests.