DAGOBERTO CALLEGARO

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Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
LIM/62 - Laboratório de Fisiopatologia Cirúrgica, Hospital das Clínicas, Faculdade de Medicina

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Autor e Coautores FMUSP-HC Normalizados: RENATA FARIA SIMM ×

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Agora exibindo 1 - 10 de 20
  • article 47 Citação(ões) na Scopus
    Cerebrospinal Fluid Aquaporin-4 Antibody Levels in Neuromyelitis Optica Attacks
    (2014) SATO, Douglas Kazutoshi; CALLEGARO, Dagoberto; JORGE, Frederico M. de Haidar; NAKASHIMA, Ichiro; NISHIYAMA, Shuhei; TAKAHASHI, Toshiyuki; SIMM, Renata Faria; APOSTOLOS-PEREIRA, Samira Luisa; MISU, Tatsuro; STEINMAN, Lawrence; AOKI, Masashi; FUJIHARA, Kazuo
    To elucidate immunopathogenetic roles of aquaporin-4 antibodies in the cerebrospinal fluid (CSF) of neuromyelitis optica spectrum disorders (NMOSD), we analyzed aquaporin-4 antibody titers, cellular and inflammatory markers in the CSF collected from 11 aquaporin-4 antibody seropositive patients. The CSF aquaporin-4 antibody levels during attacks (but not in sera) closely correlated with pleocytosis, inflammatory cytokines including interleukin-6 that can regulate antibody-producing plasmablasts, and glial fibrillary acidic protein levels in the CSF. The amount of aquaporin-4 antibodies present in the central nervous system may have therapeutic implications, as it is associated with astrocyte injury and inflammatory responses during NMOSD attacks.
  • conferenceObject
    Non-organ-specific auto-immunity disease in NMO-spectrum disorders - Brazilian experience
    (2012) APOSTOLOS-PEREIRA, S.; JORGE, F.; ZAGO, P.; SIMM, R.; FAZZITO, M.; GALVAO, C.; HOBI, C.; LANA-PEIXOTO, M.; MARCHIORI, P.; DELLAVANCE, A.; CALLEGARO, D.
  • conferenceObject
    Clinically suspected neuromyelitis optica associated to anti-MOG antibodies
    (2015) SALLES, L. M. O. de Paula; SATO, D. K.; APOATOLOS-PEREIRA, S. L.; SIMM, R. F.; JORGE, F. M. H.; FUJIHARA, K.; CALLEGARO, D.
  • conferenceObject
    Evaluation of treatment response to plasmapheresis in acute exacerbations of neuromyelitis optica
    (2014) LINHARES, G. E. S.; PEREIRA, S. L. A.; JORGE, F. M. H.; SIMM, R.; OLIVEIRA, L. M.; MENDES, L. S.; CALLEGARO, D.
  • conferenceObject
    Prevalence and clinical characteristics of neuromyelitis optica spectrum disorders patients with myelin oligodendrocyte glycoprotein antibodies
    (2013) SATO, D.; JORGE, F.; LANA-PEIXOTO, M. A.; WATERS, P.; NAKASHIMA, I.; PEREIRA, S. Apostolos; TALIM, N.; TAKAHASHI, T.; ZAGO, P.; LEITE, M. I.; BOSSO, K.; SIMM, R.; MISU, T.; AOKI, M.; FUJIHARA, K.; CALLEGARO, D.
  • conferenceObject
    Cerebrospinal Fluid Aquaporin-4 Antibody Levels in Neuromyelitis Optica Attacks
    (2015) SATO, D. K.; CALLEGARO, D.; JORGE, F. M. H.; NAKASHIMA, I.; NISHIYAMA, S.; TAKAHASHI, T.; SIMM, R. F.; APOSTOLOS-PEREIRA, S. L.; MISU, T.; STEINMAN, L.; AOKI, M.; FUJIHARA, K.
  • bookPart
    Esclerose Múltipla e Outras Doenças Desmielinizantes do Sistema Nervoso Central
    (2016) CALLEGARO, Dagoberto; SATO, Douglas Kazutoshi; JORGE, Frederico Menucci de Haidar; SIMM, Renata Faria; PEREIRA, Samira Luisa Apostolos
  • conferenceObject
    Neuromyelitis optica previously diagnosed as multiple sclerosis
    (2012) MELO, P. Zago; JORGE, F.; SIMM, R. Faria; PEREIRA, S. Apostolos; GALVAO, C.; HOBI, C.; MORAES, L.; FAZZITO, M.; SATO, D.; LANA-PEIXOTO, M.; CALLEGARO, D.
  • article 708 Citação(ões) na Scopus
    Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders
    (2014) SATO, Douglas Kazutoshi; CALLEGARO, Dagoberto; LANA-PEIXOTO, Marco Aurelio; WATERS, Patrick J.; JORGE, Frederico M. de Haidar; TAKAHASHI, Toshiyuki; NAKASHIMA, Ichiro; APOSTOLOS-PEREIRA, Samira Luisa; TALIM, Natalia; SIMM, Renata Faria; LINO, Angelina Maria Martins; MISU, Tatsuro; LEITE, Maria Isabel; AOKI, Masashi; FUJIHARA, Kazuo
    Objective:To evaluate clinical features among patients with neuromyelitis optica spectrum disorders (NMOSD) who have myelin oligodendrocyte glycoprotein (MOG) antibodies, aquaporin-4 (AQP4) antibodies, or seronegativity for both antibodies.Methods:Sera from patients diagnosed with NMOSD in 1 of 3 centers (2 sites in Brazil and 1 site in Japan) were tested for MOG and AQP4 antibodies using cell-based assays with live transfected cells.Results:Among the 215 patients with NMOSD, 7.4% (16/215) were positive for MOG antibodies and 64.7% (139/215) were positive for AQP4 antibodies. No patients were positive for both antibodies. Patients with MOG antibodies represented 21.1% (16/76) of the patients negative for AQP4 antibodies. Compared with patients with AQP4 antibodies or patients who were seronegative, patients with MOG antibodies were more frequently male, had a more restricted phenotype (optic nerve more than spinal cord), more frequently had bilateral simultaneous optic neuritis, more often had a single attack, had spinal cord lesions distributed in the lower portion of the spinal cord, and usually demonstrated better functional recovery after an attack.Conclusions:Patients with NMOSD with MOG antibodies have distinct clinical features, fewer attacks, and better recovery than patients with AQP4 antibodies or patients seronegative for both antibodies.
  • bookPart
    Atualização em Esclerose Múltipla
    (2016) APOSTOLOS-PEREIRA, Samira Luísa; SIMM, Renata Faria; JORGE, Frederico Mennucci de Haidar; SATO, Douglas Kazutoshi; CALLEGARO, Dagoberto