LUCAS AUGUSTO MOYSES FRANCO
Projetos de Pesquisa
Unidades Organizacionais
LIM/46 - Laboratório de Parasitologia Médica, Hospital das Clínicas, Faculdade de Medicina
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- Simultaneous colonization by Escherichia coli and Klebsiella pneumoniae harboring mcr-1 in Brazil(2019) PERDIGAO NETO, Lauro Vieira; CORSCADDEN, Louise; MARTINS, Roberta Cristina Ruedas; NAGANO, Debora Satie; CUNHA, Marcos Paulo Vieira; NEVES, Patricia Regina; FRANCO, Lucas Augusto Moyses; MOURA, Maria Luisa Nascimento; RIZEK, Camila Fonseca; GUIMARAES, Thais; BOSZCZOWSKI, Icaro; ROSSI, Flavia; LEVIN, Anna S.; STABLER, Richard A.; COSTA, Silvia F.Case presentationWe present a case report of a woman, concurrently colonized by polymyxin-resistant E. coli and K. pneumoniae. A Brazilian female patient, in her mid-fifties, was hospitalized with schistosomiasis. During hospitalization, polymyxin-resistant E. coli and K. pneumoniae were isolated from surveillance cultures.MethodsIdentification, antimicrobial susceptibility testings, PCR for mcr-1, plasmid transfer by conjugation and whole genome sequencing were performed.ResultsE. coli ST744 and K. pneumoniae ST101 carrying mcr-1 gene were described. Transconjugant E. coli was positive for mcr-1 and IncX4 by PCR. The plasmid is a 33,304-base pair plasmid, and the mcr-1 gene was the only antimicrobial resistance gene present in the plasmid.ConclusionsThis study presents a case report of a hospitalized woman, concurrently colonized by mcr-1-harboring E. coli ST744, a different ST from previously described in Brazil, and a K. pneumoniae ST101.