LUCAS AUGUSTO MOYSES FRANCO

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LIM/46 - Laboratório de Parasitologia Médica, Hospital das Clínicas, Faculdade de Medicina

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Revista / Livro: American Journal of Tropical Medicine and Hygiene ×

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Agora exibindo 1 - 2 de 2
  • article 0 Citação(ões) na Scopus
    Case Report: Cutaneous Leishmaniasis in a Rheumatoid Arthritis Patient Receiving Methotrexate
    (2022) AMATO, Valdir Sabbaga; SOUZA, Regina Maia de; FRANCO, Lucas Augusto Moyses; MARTINS, Roberta Cristina Ruedas; SILVA, Camila Alves Maia da; EMORI, Christini Takemi; CELESTE, Beatriz Julieta; CASTANHEIRA, Gabriel Victor; TUON, Felipe Francisco
    The immunosuppressive effect of methotrexate has rarely been associated with reactivation of cutaneous leishmaniasis. Here we present a case of a cutaneous leishmaniasis patient with atypical clinical symptoms without splenomegaly but with cutaneous manifestations after treatment of rheumatoid arthritis with methotrexate and blood recovery of the parasite. Next-generation sequencing was used to identify Leishmania infantum chagasi in the patient's blood sample.
  • article 0 Citação(ões) na Scopus
    Case Report: In Situ and Systemic Immune Response to Mucosal Leishmaniasis in an HIV-Infected Patient
    (2024) AMATO, Valdir Sabbaga; FRANCO, Lucas Augusto Moyses; SOUZA, Regina Maia de; SILVA, Camila Alves Maia da; RAMUNDO, Mariana Severo; CORTES, Marina Farrel; CORREA-CASTRO, Gabriela; SANTOS-OLIVEIRA, Joanna Reis; DA-CRUZ, Alda M.; PAGLIARI, Carla; GALO, Luciane Kanashiro; TUON, Felipe Francisco
    In situ and systemic evaluations of the immune responses of HIV -infected patients to mucosal leishmaniasis have been poorly described. We describe a recently diagnosed HIV -infected patient with mucosal leishmaniasis who was characterized by a CD4 count of 85 cells/mm3 and nasal septum destruction resulting from pruritic and ulcerated nasal mucosa with crust formation and progression over 2 years. In situ and systemic immune evaluations of T cell activation, memory, and exhaustion were conducted using cytofluorometric assays, and sequencing of the Leishmania species was performed. The immune profile of HIV -infected patient with mucosal leishmaniasis shows a mixed Th1/Th2 pattern and an activated and exhausted status.