JOEL CLAUDIO HEIMANN
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Clínica Médica, Faculdade de Medicina - Docente
LIM/16 - Laboratório de Fisiopatologia Renal, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/16 - Laboratório de Fisiopatologia Renal, Hospital das Clínicas, Faculdade de Medicina - Líder
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conferenceObject Small litter size at birth is associated with insulin resistance and low energy expenditure in adulthood(2013) TAVARES, N. K. A.; AGUIAR, F. J.; FURUKAWA, L. N. S.; HEIMANN, J. C.Objective: To evaluate the effect of litter size standardization at birth on adult metabolic parameters. Methods: Female Wistar rats were mated and became pregnant at 12 weeks of age. Offspring were divided into control(C), S8(8) and S4(4 newborns/litter) groups. At 12 weeks of age, food intake (FI,g/day), glucose (G,mg/dL), insulin (I,pM), cholesterol (Chol,mg/dL), triacylglycerols (TAG,mg/dL) levels, white and brown adipose tissue (BAT) masses (g/100g) adiposity index (AI,% BW) were determined. Results: (mean±SEM p<0.05, n=6to32)1p<0.05 vs C and S8; 2p<0.05 vs S8 and S4; 3p<0.05 vs C; 4p<0.05 vs S8 Conclusion: Results suggest that the litter size is associated with insulin resistance and low energy expenditure in adulthood.conferenceObject HIGH-SALT INTAKE DURING PREGNANCY MODIFIES PLACENTA PHENOTYPE AT LEAST UNTIL THE THIRD GENERATION(2014) PERES, Maria A.; SOTO, Sonia F.; GUIMARADES, Carina F.; SILVA, Rafaela C. P.; OLIVEIRA, Ivone B. de; FURUKAWA, Luzia N. S.; HEIMANN, Joel C.conferenceObject FINE PARTICULATE MATTER IN THE AIR WITHIN THE LIMITS RECOMMENDED BY WHO ALTERS PLACENTAL STRUCTURE(2014) SOTO, Sonia; LOPES, Karen; OLIVEIRA, Ivone; SOUZA, Regiane; MARCHESI, Guilherme; VERAS, Mariana; HEIMANN, JoelconferenceObject Exposure to air pollution before and during pregnancy: Effect on placental structure(2013) SOTO, S. F.; VERAS, M. M.; HEIMANN, J. L.Objective: To evaluate the effects of exposure to air pollution before and during pregnancy. Methods: Female Wistar rats were exposed to filtrated (F) or polluted (P) air in an Atmospheric Particle Concentrator during 3 weeks before pregnancy. At 12 weeks of age, the animals were mated and pregnant females divided in four subgroups (FF, FP, PF and PP). At 19th day of pregnancy, placentas were collected. Placental (Pl) and deciduous (Dc) longitudinal (LD) and transversal (TD) diameters were measured. Results:(mean SEM–p<0.05 mm): 1p<0.05 vs FF; 2p<0.05 vs FF, PF, PP; 3p<0.05 vs FF; 4p<0.05 vs FF, PP; 5p<0.05 vs FF; 6p<0.05 vs PF Conclusions: Exposure to air pollution affects placental structure indicating a possible impairment of fetal nutrition.