LIVIA STOCCO SANCHES VALENTIN
Projetos de Pesquisa
Unidades Organizacionais
LIM/08 - Laboratório de Anestesiologia, Hospital das Clínicas, Faculdade de Medicina
2 resultados
Resultados de Busca
Agora exibindo 1 - 2 de 2
- S100B protein and neuron-specific enolase as predictors of cognitive dysfunction after coronary artery bypass graft surgery A prospective observational study(2016) SILVA, Fernando P.; SCHMIDT, Andre P.; VALENTIN, Livia S.; PINTO, Katia O.; ZEFERINO, Suely P.; OSES, Jean P.; WIENER, Carolina D.; OTSUKI, Denise A.; TORT, Adriano B. L.; PORTELA, Luis V.; SOUZA, Diogo O.; AULER JR., Jose O. C.; CARMONA, Maria J. C.BACKGROUND Postoperative cognitive dysfunction (POCD) may be related to the systemic inflammatory response and an increase in serum markers of brain injury such as S100B protein and neuron-specific enolase (NSE). OBJECTIVE The study aims to evaluate the association between POCD and serum levels of S100B and NSE after coronary artery bypass grafting surgery (CABG). DESIGN Prospective observational study. SETTING Single university teaching hospital. PATIENTS We investigated 88 patients undergoing CABG. MAIN OUTCOMES MEASURES Cognitive function was measured preoperatively, and at the 21st and 180th postoperative days (i.e. 6 months after surgery). S100B protein and NSE serum levels were evaluated preoperatively, after induction of anaesthesia, at the end of surgery and at 6 and 24 h after surgery. RESULTS The incidence of POCD was 26.1% at 21 days after surgery and 22.7% at 6 months after surgery. Increased serum levels of S100B protein and NSE were observed postoperatively and may indicate brain damage. CONCLUSION Although serum levels of S100B protein and NSE are both significantly increased postoperatively, our findings indicate that serum levels of S100B protein may be more accurate than NSE in the detection of POCD after CABG.
conferenceObject Lower educational level is a possible risk factor for postoperative cognitive dysfunction after surgery under general anesthesia(2012) VALENTIN, Livia S. S.; ANDRADE, Jessica F.; SOUZA, Leticia Maria A.; LUZ, Vinicius Fernando Da; OSTERNACK-PINTO, KatiaIntroduction: Elderly patients with postoperative cognitive dysfunction (POCD) have an increased risk of mortality, especially after major surgery1. High educational level is regarded as a protective factor for developing dementia, especially Alzheirmer's disease2, but little is known about educational level in the development of POCD. Objective: This study aims evaluating the influence of the level of education in the incidence of POCD in elderly patients undergoing surgery under general anesthesia. Methods: Seventy one patients older than 60 years old undergoing surgery under general anesthesia were evaluated before surgery and on 7th postoperative (P.O.) day by TICS (Telephone Interview for Cognitive- Standardized, instrument that assesses by telephone the skills of spatial and temporal orientation and memory, requiring only the ability to verbal understanding). Low educational level (LEL) was defined as 4 or less years of formal education and high educational level (HEL) was defined as 8 or more years of formal education. Statistical analysis was performed with SPSS 17.0, using nonparametric analysis of ordinal data with repeated measurements. P values inferior to 0,05 were considered significant. Results: HEL and LEL groups presented different TICS values since preoperative period (P = 0.032). For comparison between pre and postoperative period, the HEL group presented TICS values of 29.8±5.9 before surgery and 29.0±7.3 at 7th P.O. and for LEL group the TICS values were 17.6±3.1 and 16.7±2.6, respectively, without difference between groups (P = 0.07). Conclusions: The differences in the TICS values observed since the preoperative period are normal for the educational levels evaluated3. Although the decreasing of mean TICS value of the LEL group (5.11%) was greater than the HEL group (2.68%), the sample size analyzed wasn't enough the prove that low educational level is a risk factor for POCD.