LEONEL TADAO TAKADA
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
20 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 20
bookPart Doença de Alzheimer(2021) TAKADA, Leonel Tadao; SMID, Jerusa; STUDART NETO, Adalberto; NITRINI, Ricardo- Genetic investigation of dementias in clinical practice(2022) TAKADA, Leonel TadaoBackground: The field of neurodegenerative dementia genetics has advanced significantly over the past two decades, but there are still more to be discovered (such as the gene mutation in some familial forms of dementia). Objective: To provide a brief review of the most recent discoveries regarding monogenic dementia, and covering the most frequent genetic diseases that can cause dementia (neurodegenerative or not). Methods: A review of the literature will be carried out.Results: Neurodegenerative dementias, vascular dementias and leukoencephalopathies caused by single pathogenic variants are presented. Conclusion: The spectrum of clinical presentations for most of the genes discussed is wide, and hence genetic testing in clinic should try to cover as many genes as possible.
- Frequency of the LRRK2 G2019S mutation in late-onset sporadic patients with Parkinson's disease(2014) CHIEN, Hsin Fen; FIGUEIREDO, Tamires Rocha; HOLLAENDER, Marianna Almeida; TOFOLI, Fabiano; TAKADA, Leonel Tadao; PEREIRA, Lygia do Veiga; BARBOSA, Egberto ReisMutations in the LRRK2 gene, predominantly G2019S, have been reported in individuals with autosomal dominant inheritance and sporadic Parkinson's disease (PD). The G2019S mutation has an age-dependent penetrance and evidence shows common ancestry. The clinical manifestations are indistinguishable from idiopathic PD. Its prevalence varies according to the population studied ranging from less than 0.1% in Asians to 41% in North African Arabs. This study aimed to identify G2019S mutation in Brazilian idiopathic PD patients. Method: We sampled 100 PD patients and 100 age- and gender-matched controls. Genetical analysis was accomplished by polymerase chain reaction (PCR). Results: No G2019S mutations were found in both patients with sporadic PD and controls. Conclusions: Our results may be explained by the relatively small sample size.
- Innate immunity and inflammation in Alzheimer's disease pathogenesis(2017) TAKADA, Leonel Tadao
bookPart Afasias progressivas primárias(2021) TAKADA, Leonel Tadao- Dominantly inherited Alzheimer's disease in Latin America: Genetic heterogeneity and clinical phenotypes(2021) LLIBRE-GUERRA, Jorge J.; LI, Yan; ALLEGRI, Ricardo F.; MENDEZ, Patricio Chrem; SURACE, Ezequiel I.; LLIBRE-RODRIGUEZ, Juan J.; SOSA, Ana Luisa; ALAEZ-VERSON, Carmen; LONGORIA, Erika-Mariana; TELLEZ, Alberto; CARRILLO-SANCHEZ, Karol; FLORES-LAGUNES, Luis Leonardo; SANCHEZ, Victor; TAKADA, Leonel Tadao; NITRINI, Ricardo; FERREIRA-FROTA, Norberto Anizio; BENEVIDES-LIMA, Joyce; LOPERA, Francisco; RAMIREZ, Laura; JIMENEZ-VELAZQUEZ, Ivonne; SCHENK, Christian; ACOSTA, Daisy; BEHRENS, Maria Isabel; DOERING, Michelle; ZIEGEMEIER, Ellen; MORRIS, John C.; MCDADE, Eric; BATEMAN, Randall J.Introduction A growing number of dominantly inherited Alzheimer's disease (DIAD) cases have become known in Latin American (LatAm) in recent years. However, questions regarding mutation distribution and frequency by country remain open. Methods A literature review was completed aimed to provide estimates for DIAD pathogenic variants in the LatAm population. The search strategies were established using a combination of standardized terms for DIAD and LatAm. Results Twenty-four DIAD pathogenic variants have been reported in LatAm countries. Our combined dataset included 3583 individuals at risk; countries with highest DIAD frequencies were Colombia (n = 1905), Puerto Rico (n = 672), and Mexico (n = 463), usually attributable to founder effects. We found relatively few reports with extensive documentation on biomarker profiles and disease progression. Discussion Future DIAD studies will be required in LatAm, albeit with a more systematic approach to include fluid biomarker and imaging studies. Regional efforts are under way to extend the DIAD observational studies and clinical trials to Latin America.
- Current clinical and research practices on frontotemporal dementia in Brazil: a national survey(2023) SOUZA, Leonardo Cruz de; BRUCKI, Sonia Maria Dozzi; SCHILLING, Lucas Porcello; SILVA, Leticia Costa da; TAKADA, Leonel Tadao; BAHIA, Valeria Santoro; BARBOSA, Breno Jose Alencar Pires; BALTHAZAR, Marcio Luiz Figueredo; FROTA, Norberto Anizio Ferreira; NITRINI, Ricardo; CARAMELLI, Paulo; SMID, JerusaBackground Frontotemporal dementia (FTD) is a frequent cause of young-onset dementia and represents a major challenge for the diagnosis and clinical management. It is essential to evaluate the difficulties faced by physicians on the diagnostic workup and on patient care.Objective The aim of this study was to investigate the current practices and the local limits on the diagnosis and management of FTD in Brazil.Methods We elaborated an online survey, composed of 29 questions and divided in four parts, comprising questions about existing health facilities, clinical practices related to FTD, and suggestions to increment the national research on FTD. The invitation to participate was sent by email to all neurologists affiliated to the Brazilian Academy of Neurology ( n = 3658), and to all physicians who attended the XII Meeting of Researchers on Alzheimer's disease, in 2019 ( n = 187). The invitation was also diffused through social media.Results 256 Brazilian physicians answered the questionnaire. The three most relevant disorders for the differential diagnosis of FTD were Alzheimer's disease (AD) ( n = 211), bipolar disorder ( n = 117) and dementia with Lewy bodies ( n = 92). Most respondents (125/256) reported the difficulty in performing genetic testing as the main limit in the diagnostic of FTD. 93% and 63% of participants considered that the assessment of social cognition and AD CSF biomarkers are useful for the diagnosis of FTD, respectively.Conclusions The present study may provide valuable insights for the medical education and clinical training of physicians, and to foster future research on FTD in Brazil.
bookPart Transtornos cognitivos maior e menor associados à doença cerebrovascular, trauma cerebral, neuroinfeccção e outras etiologias(2018) MATIOLI, Maria Niures Pimentel dos Santos; ANGHINAH, Renato; TAKADA, Leonel Tadao; PORTO, Fabio Henrique de Gobbi; NITRINI, Ricardo- Expanding MAPT p.V363I Mutation Phenotype: An Overlapping of PSP-CBS and Posterior Cortical Atrophy(2023) PARMERA, Jacy Bezerra; COUTINHO, Artur Martins; GUIMARAES, Thiago Goncalves; YAMAMOTO, Joyce Yuri Silvestre; TAKADA, Leonel Tadao; NITRINI, Ricardo; BARBOSA, Egberto Reis; BRUCKI, Sonia Maria Dozzi
- Neuropathology of frontotemporal lobar degeneration: A review(2013) BAHIA, Valéria Santoro; TAKADA, Leonel Tadao; DERAMECOURT, VincentABSTRACT Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile dementia. Three main clinical variants are widely recognized within the FTLD spectrum: the behavioural variant of frontotemporal dementia (bvFTD), semantic dementia (SD) and progressive non-fluent aphasia (PNFA). FTLD represents a highly heterogeneous group of neurodegenerative disorders which are best classified according to the main protein component of pathological neuronal and glial inclusions. The most common pathological class of FTLD is associated with the TDP-43 protein (FTLD-TDP), while FTLD-Tau is considered slightly less common while the FTLD-FUS (Fused in sarcoma protein) pathology is rare. In this review, these three major pathological types of FTLD are discussed.