LEONEL TADAO TAKADA
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
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- Dominantly inherited Alzheimer's disease in Latin America: Genetic heterogeneity and clinical phenotypes(2021) LLIBRE-GUERRA, Jorge J.; LI, Yan; ALLEGRI, Ricardo F.; MENDEZ, Patricio Chrem; SURACE, Ezequiel I.; LLIBRE-RODRIGUEZ, Juan J.; SOSA, Ana Luisa; ALAEZ-VERSON, Carmen; LONGORIA, Erika-Mariana; TELLEZ, Alberto; CARRILLO-SANCHEZ, Karol; FLORES-LAGUNES, Luis Leonardo; SANCHEZ, Victor; TAKADA, Leonel Tadao; NITRINI, Ricardo; FERREIRA-FROTA, Norberto Anizio; BENEVIDES-LIMA, Joyce; LOPERA, Francisco; RAMIREZ, Laura; JIMENEZ-VELAZQUEZ, Ivonne; SCHENK, Christian; ACOSTA, Daisy; BEHRENS, Maria Isabel; DOERING, Michelle; ZIEGEMEIER, Ellen; MORRIS, John C.; MCDADE, Eric; BATEMAN, Randall J.Introduction A growing number of dominantly inherited Alzheimer's disease (DIAD) cases have become known in Latin American (LatAm) in recent years. However, questions regarding mutation distribution and frequency by country remain open. Methods A literature review was completed aimed to provide estimates for DIAD pathogenic variants in the LatAm population. The search strategies were established using a combination of standardized terms for DIAD and LatAm. Results Twenty-four DIAD pathogenic variants have been reported in LatAm countries. Our combined dataset included 3583 individuals at risk; countries with highest DIAD frequencies were Colombia (n = 1905), Puerto Rico (n = 672), and Mexico (n = 463), usually attributable to founder effects. We found relatively few reports with extensive documentation on biomarker profiles and disease progression. Discussion Future DIAD studies will be required in LatAm, albeit with a more systematic approach to include fluid biomarker and imaging studies. Regional efforts are under way to extend the DIAD observational studies and clinical trials to Latin America.
- Dementia in Latin America: Paving the way toward a regional action plan(2021) PARRA, Mario Alfredo; BAEZ, Sandra; SEDENO, Lucas; CAMPO, Cecilia Gonzalez; SANTAMARIA-GARCIA, Hernando; APRAHAMIAN, Ivan; BERTOLUCCI, Paulo H. F.; BUSTIN, Julian; BICALHO, Maria Aparecida Camargos; CANO-GUTIERREZ, Carlos; CARAMELLI, Paulo; CHAVES, Marcia L. F.; COGRAM, Patricia; BEBER, Barbara Costa; COURT, Felipe A.; SOUZA, Leonardo Cruz de; CUSTODIO, Nilton; DAMIAN, Andres; CRUZ, Myriam de la; RODRIGUEZ, Roberta Diehl; BRUCKI, Sonia Maria Dozzi; FAJERSZTAJN, Lais; FARIAS, Gonzalo A.; FELICE, Fernanda G. De; FERRARI, Raffaele; OLIVEIRA, Fabricio Ferreira de; FERREIRA, Sergio T.; FERRETTI, Ceres; BALTHAZAR, Marcio Luiz Figueredo; FROTA, Norberto Anizio Ferreira; FUENTES, Patricio; GARCIA, Adolfo M.; GARCIA, Patricia J.; PORTO, Fabio Henrique de Gobbi; PENAILILLO, Lissette Duque; ENGLER, Henry Willy; MAIER, Irene; MATA, Ignacio F.; GONZALEZ-BILLAULT, Christian; LOPEZ, Oscar L.; MORELLI, Laura; NITRINI, Ricardo; QUIROZ, Yakeel T.; BARRAGAN, Alejandra Guerrero; HUEPE, David; PIO, Fabricio Joao; SUEMOTO, Claudia Kimie; KOCHHANN, Renata; KOCHEN, Silvia; KUMFOR, Fiona; LANATA, Serggio; MILLER, Bruce; MANSUR, Leticia Lessa; HOSOGI, Mirna Lie; LILLO, Patricia; GUERRA, Jorge Llibre; LIRA, David; LOPERA, Francisco; COMAS, Adelina; AVILA-FUNES, Jose Alberto; SOSA, Ana Luisa; RAMOS, Claudia; RESENDE, Elisa de Paula Franca; SNYDER, Heather M.; TARNANAS, Ioannis; YOKOYAMA, Jenifer; LLIBRE, Juan; CARDONA, Juan Felipe; POSSIN, Kate; KOSIK, Kenneth S.; MONTESINOS, Rosa; MOGUILNER, Sebastian; SOLIS, Patricia Cristina Lourdes; FERRETTI-REBUSTINI, Renata Eloah de Lucena; RAMIREZ, Jeronimo Martin; MATALLANA, Diana; MBAKILE-MAHLANZA, Lingani; TON, Alyne Mendonca Marques; TAVARES, Ronnielly Melo; MIOTTO, Eliane C.; MUNIZ-TERRERA, Graciela; MUNOZ-NEVAREZ, Luis Arnoldo; OROZCO, David; OLIVEIRA, Maira Okada de; PIGUET, Olivier; CAIPA, Maritza Pintado; ESCUDERO, Stefanie Danielle Pina; SCHILLING, Lucas Porcello; PALMEIRA, Andre Luiz Rodrigues; YASSUDA, Monica Sanches; SANTACRUZ-ESCUDERO, Jose Manuel; SERAFIM, Rodrigo Bernardo; SMID, Jerusa; SLACHEVSKY, Andrea; SERRANO, Cecilia; SOTO-ANARI, Marcio; TAKADA, Leonel Tadao; GRINBERG, Lea Tenenholz; TEIXEIRA, Antonio Lucio; BARBOSA, Maira Tonidandel; TREPEL, Dominic; IBANEZ, AgustinAcross Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF.
- Biomarkers for dementia in Latin American countries: Gaps and opportunities(2023) PARRA, Mario A.; ORELLANA, Paulina; LEON, Tomas; VICTORIA, Cabello G.; HENRIQUEZ, Fernando; GOMEZ, Rodrigo; AVALOS, Constanza; DAMIAN, Andres; SLACHEVSKY, Andrea; IBANEZ, Agustin; ZETTERBERG, Henrik; TIJMS, Betty M.; YOKOYAMA, Jennifer S.; PINA-ESCUDERO, Stefanie D.; COCHRAN, J. Nicholas; MATALLANA, Diana L.; ACOSTA, Daisy; ALLEGRI, Ricardo; ARIAS-SUAREZ, Bianca P.; BARRA, Bernardo; BEHRENS, Maria Isabel; BRUCKI, SoniaM. D.; BUSATTO, Geraldo; CARAMELLI, Paulo; CASTRO-SUAREZ, Sheila; CONTRERAS, Valeria; CUSTODIO, Nilton; DANSILIO, Sergio; CRUZ-PUEBLA, Myriam De la; SOUZA, Leonardo Cruz de; DIAZ, Monica M.; DUQUE, Lissette; FARIAS, Gonzalo A.; FERREIRA, Sergio T.; GUIMET, Nahuel Magrath; KMAID, Ana; LIRA, David; LOPERA, Francisco; MEZA, Beatriz Mar; MIOTTO, Eliane C.; NITRINI, Ricardo; NUNEZ, Alberto; O'NEILL, Santiago; OCHOA, John; PINTADO-CAIPA, Maritza; RESENDE, Elisa de Paula Franca; RISACHER, Shannon; ROJAS, Luz Angela; SABAJ, Valentina; SCHILLING, Lucas; SELLEK, Allis F.; SOSA, Ana; TAKADA, Leonel T.; TEIXEIRA, Antonio L.; UNAUCHO-PILALUMBO, Martha; DURAN-ANIOTZ, ClaudiaLimited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we reported a survey to explore the ongoing work, needs, interests, potential barriers, and opportunities for future studies related to biomarkers. The results show that neuroimaging is the most used biomarker (73%), followed by genetic studies (40%), peripheral fluids biomarkers (31%), and cerebrospinal fluid biomarkers (29%). Regarding barriers in LAC, lack of funding appears to undermine the implementation of biomarkers in clinical or research settings, followed by insufficient infrastructure and training. The survey revealed that despite the above barriers, the region holds a great potential to advance dementia biomarkers research. Considering the unique contributions that LAC could make to this growing field, we highlight the urgent need to expand biomarker research. These insights allowed us to propose an action plan that addresses the recommendations for a biomarker framework recently proposed by regional experts.