FRANCISCO RAFAEL MARTINS LAURINDO

(Fonte: Lattes)
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Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/64, Hospital das Clínicas, Faculdade de Medicina - Líder

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Revista / Livro: Arquivos Brasileiros de Cardiologia ×

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Agora exibindo 1 - 5 de 5
  • article 0 Citação(ões) na Scopus
    Translational Medicine and Implementation Science: How to Transform What We Know Into What We Do
    (2022) LUZ, Protasio Lemos da; LAURINDO, Francisco Rafael Martins
  • article 1 Citação(ões) na Scopus
    Assessment of Stent Strut Endothelialization in Iliac Arteries of Rabbits
    (2012) TAKIMURA, Celso Kiyochi; WATANABE, Ii-sei; LAURINDO, Francisco Rafael Martins; GUTIERREZ, Paulo Sampaio; AIELLO, Vera Demarchi; MORATO, Spero Penha; LEMOS NETO, Pedro Alves
    Background: Fast post-implantation stent endothelialization is desirable for theoretically reducing the possibility of stent thrombosis. Objective: To evaluate the extent of sirolimus-eluting stent strut endothelialization (delivered from the luminal and abluminal aspects or abluminal aspect only) in the iliac arteries of rabbits. Methods: The iliac arteries of 10 rabbits were implanted with four sirolimus-eluting stents in the luminal and abluminal aspects, three sirolimus-eluting stents in the abluminal aspect, six polymer-coated stents, and four uncoated stents. After four weeks, the rabbits were euthanized and scanning electron microscopy was performed to quantify the area of exposed stent strut as well as the percentage of endothelialization. Results: The area (mean +/- SD) (mm(2)) of exposed uncoated stent struts, polymer-coated stents, sirulimus-eluting stent in the abluminal and luminal aspects and sirolimus-eluting stent in the abluminal aspect was 0.12 +/- 0.08, 0.09 +/- 0.12, 0.60 +/- 0.67 and 0.05 +/- 0.04, respectively (p = 0.120). The percentage of endothelialization (mean +/- SD) (%) of uncoated stents, polymer-coated stents, sirolimus-eluting stents in the luminal and abluminal aspects and sirolimus-eluting stents in the abluminal aspect was 99 +/- 01, 99 +/- 0. 97 +/- 03 and 99 +/- 0, respectively (p = 0.133). Conclusion: After four weeks of implantation in the iliac arteries of rabbits, both the sirolimus-eluting stents in the luminal plus abluminal aspects and those in the abluminal aspect only showed stent strut endothelialization rates similar to those of the other types of non-drug eluting stents.
  • article 0 Citação(ões) na Scopus
    Cardioprotective Effects of Melatonin in Reperfusion Injury
    (2018) LAURINDO, Francisco R. M.
  • article 1 Citação(ões) na Scopus
    Internacionalizar é Preciso, mas é o Bastante?
    (2018) OLIVEIRA, Glaucia Maria Moraes de; LORENZO, Andrea De; COLOMBO, Fernanda Marciano Consolim; STERNICK, Eduardo Back; BRANDAO, Andrea Araujo; KAISER, Sergio Emanuel; QUADROS, Alexandre Schaan de; KALIL, Renato Abdala Karam; SCARAMELLO, Christianne Bretas Vieira; LAURINDO, Francisco Rafael Martins; HAJJAR, Ludhmila Abrahao
  • article 3 Citação(ões) na Scopus
    Estudo Pré-Clínico de Stent com Polímero Biodegradável e Liberação Abluminal de Sirolimus
    (2014) TAKIMURA, Celso Kiyochi; CAMPOS, Carlos Augusto Homem M.; MELO, Pedro Henrique Magualhães Craveiro; CAMPOS, Julliana Carvalho; GUTIERREZ, Paulo Sampaio; BORGES, Thiago Francisco Costa; CURADO, Luciano; MORATO, Spero Penha; LAURINDO, Francisco Rafael Martins; LEMOS NETO, Pedro Alves
    Background: Bioabsorbable polymer stents with drug elution only on the abluminal surface may be safer than durable polymer drug-eluting stents. Objective: To report the experimental findings with the Inspiron(tm) stent - a bioabsorbable polymer-coated stent with sirolimus release from the abluminal surface only, recently approved for clinical use. Methods: 45 stents were implanted in the coronary arteries of 15 pigs. On day 28 after implantation, angiographic, intracoronary ultrasonographic and histomorphological data were collected. Five groups were analyzed: Group I (nine bare-metal stents); Group II (nine coated with bioabsorbable polymer on the luminal and abluminal surfaces); Group III (eight stents coated with bioabsorbable polymer on the abluminal surface); Group IV (nine stents with bioabsorbable polymer and sirolimus on the luminal and abluminal surfaces); and Group V (ten stents with bioabsorbable polymer and sirolimus only on the abluminal surface). Results: The following results were observed for Groups I, II, III, IV and V, respectively: percentage stenosis of 29 ± 20; 36 ± 14; 33 ± 19; 22 ± 13 and 26 ± 15 (p = 0.443); late lumen loss (in mm) of 1.02 ± 0.60; 1.24 ± 0.48; 1.11 ± 0.54; 0.72 ± 0.44 and 0.78 ± 0.39 (p = 0.253); neointimal area (in mm2)) of 2.60 ± 1.99; 2.74 ± 1.51; 2.74 ± 1.30; 1.30 ± 1.14 and 0.97 ± 0.84 (p = 0.001; Groups IV and V versus Groups I, II and III); and percentage neointimal area of 35 ± 25; 38 ± 18; 39 ± 19; 19 ± 18 and 15 ± 12 (p = 0.001; Groups IV and V versus Groups I, II and III). Injury and inflammation scores were low and with no differences between the groups. Conclusion: The Inspiron(tm) stent proved to be safe and was able to significantly inhibit the neointimal hyperplasia observed on day 28 after implantation in porcine coronary arteries.