SALMA ROSE IMANARI RIBEIZ
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
12 resultados
Resultados de Busca
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- Validation of a treatment algorithm for major depression in an older Brazilian sample(2013) RIBEIZ, Salma R. I.; AVILA, Renata; MARTINS, Camila B.; MOSCOSO, Marco A. A.; STEFFENS, David C.; BOTTINO, Cassio M. C.Objective The aim of this study was to investigate the effectiveness of a modified version of the Duke Somatic Algorithm Treatment for Geriatric Depression (STAGED) in a Brazilian sample of older patients with major depression. Besides, we aimed to investigate possible baseline predictive factors for remission in this sample. Methods Sixty-seven depressed individuals were treated according to STAGED over 24 weeks in a prospective cohort design with follow-up. All patients had criteria for major depression and were at least 60 years of age at baseline enrollment. Results During this follow-up, 56 patients could be classified in remitted or not remitted group, 42.85% reached remission, and 57.14% did not reach remission. These results are even better than those found in the original study, probably due to the lower baseline depression severity of our sample. When baseline characteristics were compared between remitted and not remitted groups, scores of Mini Mental State Examination and Cambridge Cognitive Examination (CAMCOG) were the only variables with statistical significant difference (p<0.05) between groups. Logistic regression analysis was carried out to try to predict remission and statistical significance (p<0.05) was found only for baseline MMSE scores. It may mean that patients with mixed cognitive disorders and mood disorders have a worse course of depression. Conclusions This version of STAGED seems to be a useful strategy for treatment of depression in late life. Baseline general cognitive performance might be useful to predict remission of depression in older patients with mild to moderate depression. Further research with different population characteristics should be conducted in order to evaluate its usefulness and feasibility in different settings.
- Serum cortisol level and depression severity in a sample of Brazilian elders(2017) ARAUJO, Luis Fernando S. C. de; RIBEIZ, Salma Rose Imanari; MARTINS, Camila Bertini; BOTTINO, Cassio M. C.
- Structural Brain Changes as Biomarkers and Outcome Predictors in Patients with Late-Life Depression: A CrossSectional and Prospective Study(2013) RIBEIZ, Salma R. I.; DURAN, Fabio; OLIVEIRA, Melaine C.; BEZERRA, Diana; CASTRO, Claudio Campi; STEFFENS, David C.; BUSATTO FILHO, Geraldo; BOTTINO, Cassio M. C.The relationship between structural changes in grey matter and treatment response in patients with late-life depression remains an intriguing area of research. This magnetic resonance imaging (MRI) study compares the baseline grey matter volume of elderly people with and without major depression (according to the DSM-IV-TR criteria) and assesses its association with antidepressant treatment response. Brain MRI scans were processed using statistical parametric mapping and voxel-based morphometry. The sample consisted of 30 patients with depression and 22 healthy controls. We found a significant volumetric reduction in the orbitofrontal cortex bilaterally in patients in comparison with controls. According to their remission status after antidepressant treatment, patients were classified as remitted or not remitted. Compared with controls, remitted patients showed a volumetric reduction in the orbitofrontal cortex bilaterally and in another cluster in the right middle temporal pole. Non-remitted patients showed an even greater volumetric reduction in the orbitofrontal cortex bilaterally compared with controls. To investigate predictive factors of remission after antidepressant treatment, we used a logistic regression. Both baseline Mini Mental State Examination score and baseline left superior lateral orbitofrontal cortex volume (standardized to the total grey matter volume) were associated with remission status. Our findings support the use of regional brain atrophy as a potential biomarker for depression. In addition, baseline cognitive impairment and regional grey matter abnormalities predict antidepressant response in patients with late-life depression.
conferenceObject Depressive symptoms in older primary care patients: Results of the ""prevention and treatment of depression in elderly"" study in Brazil(2015) BOTTINO, Cassio M. C.; RIBEIZ, Salma; BASSOLI, Lucas; ALEXANDRINO-SILVA, Clovis- Treatment of Depression in Older Adults(2012) BOTTINO, Cassio M. C.; BARCELOS-FERREIRA, Ricardo; RIBEIZ, Salma R. I.Depression is the most frequent mental disorder in older people, often causing emotional distress and reduced quality of life. Despite its clinical significance, depression remains underdiagnosed and inadequately treated in older patients. Regarding prognosis, data suggest that almost 70% of patients, treated long enough and with appropriate doses, recover from an index episode of depression. Antidepressants are efficient for treating depressed outpatients with several comorbid physical diseases as well as hospitalized patients, with selective serotonin reuptake inhibitors being the antidepressants of choice for older patients. Available data can guide pharmacological treatment in both the acute and maintenance stages, but further research is required to guide clinical strategies when remission is not achieved. Approaches for the management of resistance to treatment are summarized, including optimization strategies, drug changes, algorithms, and combined and augmentation pharmacological treatments. Finally, additional therapeutic choices such as electroconvulsive therapy, transcranial magnetic stimulation, and integrated psychotherapy are presented.
- DTI voxelwise analysis did not differentiate older depressed patients from older subjects without depression(2012) BEZERRA, Diana Moitinho; PEREIRA, Fabricio R. S.; CENDES, Fernando; JACKOWSKI, Marcel Parolin; NAKANO, Eduardo Y.; MOSCOSO, Marco A. A.; RIBEIZ, Salma R. I.; AVILA, Renata; CASTRO, Claudio Campi de; BOTTINO, Cassio M. C.Introduction: Neuroimaging has been widely used in studies to investigate depression in the elderly because it is a noninvasive technique, and it allows the detection of structural and functional brain alterations. Fractional anisotropy (FA) and mean diffusivity (MD) are neuroimaging indexes of the microstructural integrity of white matter, which are measured using diffusion tensor imaging (DTI). The aim of this study was to investigate differences in FA or MD in the entire brain without a previously determined region of interest (ROI) between depressed and non-depressed elderly patients. Method: Brain magnetic resonance imaging scans were obtained from 47 depressed elderly patients, diagnosed according to DSM-IV criteria, and 36 healthy elderly patients as controls. Voxelwise statistical analysis of FA data was performed using tract-based spatial statistics (TBSS). Results: After controlling for age, no significant differences among FA and MD parameters were observed in the depressed elderly patients. No significant correlations were found between cognitive performance and FA or MD parameters. Conclusion: There were no significant differences among FA or MD values between mildly or moderately depressed and non-depressed elderly patients when the brain was analyzed without a previously determined ROI.
- Effect of temporal lobe structure volume on memory in elderly depressed patients(2011) AVILA, Renata; RIBEIZ, Salma; DURAN, Fabio L. S.; ARRAIS, Jony P. J.; MOSCOSO, Marco A. A.; BEZERRA, Diana M.; JALUUL, Omar; CASTRO, Claudio C.; BUSATTO, Geraldo F.; BOTTINO, Cassio M. C.Objective: To compare the volume of the hippocampus and parahippocampal gyrus in elderly individuals with and without depressive disorders, and to determine whether the volumes of these regions correlate with scores on memory tests. Method: Clinical and demographic differences, as well as differences in regional gray matter volumes, were assessed in 48 elderly patients with depressive disorders and 31 control subjects. Brain (structural MRI) scans were processed using statistical parametric mapping and voxel-based morphometry. Cognitive tests were administered to subjects in both groups. Results: There were no between-group gray matter volume differences in the hippocampus or parahippocampal gyrus. In the elderly depressed group only, the volume of the left parahippocampal gyrus correlated with scores on the delayed naming portion of the visual verbal learning test. There were also significant direct correlations in depressed subjects between the volumes of the left hippocampus, right and left parahippocampal gyrus and immediate recall scores on verbal episodic memory tests and visual learning tests. In the control group, there were direct correlations only between overall cognitive performance (as assessed with the MMSE) and the volume of right hippocampus, and between the total score on the visual verbal learning test and the volume of the right and left parahippocampal gyrus. Conclusions: These findings highlight different patterns of relationship between cognitive performance and volumes of medial temporal structures in depressed individuals and healthy elderly subjects. The direct correlation between delayed visual verbal memory recall scores with left parahippocampal volumes specifically in elderly depressed individuals provides support to the view that depression in elderly populations may be a risk factor for dementia.
- Relationship between Brain Age-Related Reduction in Gray Matter and Educational Attainment(2015) RZEZAK, Patricia; SQUARZONI, Paula; DURAN, Fabio L.; ALVES, Tania de Toledo Ferraz; TAMASHIRO-DURAN, Jaqueline; BOTTINO, Cassio M.; RIBEIZ, Salma; LOTUFO, Paulo A.; MENEZES, Paulo R.; SCAZUFCA, Marcia; BUSATTO, Geraldo F.Inter-subject variability in age-related brain changes may relate to educational attainment, as suggested by cognitive reserve theories. This voxel-based morphometry study investigated the impact of very low educational level on the relationship between regional gray matter (rGM) volumes and age in healthy elders. Magnetic resonance imaging data were acquired in elders with low educational attainment (less than 4 years) (n = 122) and high educational level (n = 66), pulling together individuals examined using either of three MRI scanners/acquisition protocols. Voxelwise group comparisons showed no rGM differences (p<0.05, family-wise error corrected for multiple comparisons). When within-group voxel-wise patterns of linear correlation were compared between high and low education groups, there was one cluster of greater rGM loss with aging in low versus high education elders in the left anterior cingulate cortex (p<0.05, FWE-corrected), as well as a trend in the left dorsomedial prefrontal cortex (p<0.10). These results provide preliminary indication that education might exert subtle protective effects against age-related brain changes in healthy subjects. The anterior cingulate cortex, critical to inhibitory control processes, may be particularly sensitive to such effects, possibly given its involvement in cognitive stimulating activities at school or later throughout life.
conferenceObject Physical activity and depressive symptoms in the elderly: A population-based study(2015) ALEXANDRINO-SILVA, Clovis; RIBEIZ, Salma; BASSOLLI, Lucas; BOTTINO, Cassio- Psychotic symptoms in older people without dementia from a Brazilian community-based sample(2015) SOARES, Walter Barbalho; RIBEIZ, Salma Rose I.; BASSITT, Debora P.; OLIVEIRA, Melaine C. De; BOTTINO, Cassio M. C.BackgroundThe international prevalence of psychotic symptoms in older subjects without dementia varies from 0.9% to 8.0%. However, an analysis of these symptoms in developing countries has not been undertaken. AimsTo determine the prevalence and to correlate these symptoms with socioeconomic and clinical characteristics. MethodA community-based sample aged 60years and older was evaluated. Those who screened positive for dementia, cognitive and functional impairment or significant depressive symptoms were excluded, resulting in 1125 individuals. ResultsThe prevalence of psychotic symptoms was 9.1% (visual/tactile hallucinations, 7.8%; auditive hallucinations, 7.5%; persecutory delusions, 2.9%). Subjects with psychotic symptoms had lower Mini Mental State Examination and The Bayer Activities of Daily Living Scale scores, fewer years of schooling, belonged to lower socioeconomic classes compared with non-psychotic subjects, and 80% had clinical comorbidities. ConclusionsThe prevalence was in the upper range of international data. Significant relationships were found between psychotic symptoms and lower Mini Mental State Examination score, fewer years of schooling and lower socioeconomic class. Clinical comorbidity was also very frequent.