RONALDO HONORATO BARROS DOS SANTOS

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11
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Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico

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Autor e Coautores FMUSP-HC Normalizados: FABIO ANTONIO GAIOTTO × Tipo de acesso: restrictedAccess ×

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Agora exibindo 1 - 8 de 8
  • conferenceObject
    A New Allocation System for Priorization in Heart Transplantation in the State of Sao Paulo - Brazil: Its Impact on Patients in ECMO
    (2022) STEFFEN, Samuel P.; GAIOTTO, Fabio A.; GASPAR, Shyrline F.; SANTOS, Ronaldo Honorato B.; FILHO, Domingos D. L.; BACAL, Fernando; JATENE, Fabio B.
  • conferenceObject
    Frofile of Donor Hearts in Brazil
    (2014) MELO, J. L.; PAULO, A. R.; SOUZA, J. A.; OHE, L. A.; BARBOSA, M. B.; AVILA, M. S.; MARCONDES-BRAGA, E. G.; SEGURO, L. B.; MANGINI, S.; SANTOS, R. H.; LOURENCO FILHO, D. D.; GAIOTTO, F. A.; KAWABE, L. T.; BACAL, F.
  • conferenceObject
    Endomyocardial Biopsy after Heart Transplantation. When is Too Late?
    (2019) CEPEDA, L. M. Guerrero; MARCONDES-BRAGA, F. G.; COSTA, D. M.; MENDES, R. M.; DUARTE, S.; OLIVEIRA, J. C.; WOSNIACK, I.; SEGURO, L. F.; MANGINI, S.; GAIOTTO, F.; SANTOS, R. H.; AVILA, M. S.; BACAL, F.
  • conferenceObject
    VA ECMO SUPPORT IN A HEART TRANSPLANT CENTER: BRIDGE TO TRANSPLANT AND BRIDGE TO RECOVERY FROM SEVERE PRIMARY GRAFT DYSFUNCTION
    (2019) STEFFEN, Samuel; ABAURRE, Vitor; GAIOTTO, Fabio; HONORATO, Ronaldo; LOURECO, Domingos; GASPAR, Shirlyne; BRAGA, Fabiana; GRINBERG, Monica; MANGINI, Sandrigo; SEGURO, Luiz; WOSNIAK, Lascara; GALAS, Filomena; BACAL, Fernando; JATENE, Fabio
  • conferenceObject
    Heart Transplant Team and Its Impact in the Results of Heart Transplant in a Brazilian Center
    (2015) SEGURO, L. F.; MARCONDES-BRAGA, F.; AVILA, M. S.; MANGINI, S.; LOURENCO FILHO, D. D.; SANTOS, R. H.; GAIOTTO, F. A.; BACAL, F.
  • article 39 Citação(ões) na Scopus
    Myocardial Infarction-Associated Transcript, a Long Noncoding RNA, Is Overexpressed During Dilated Cardiomyopathy Due to Chronic Chagas Disease
    (2016) FRADE, Amanda Farage; LAUGIER, Laurie; FERREIRA, Ludmila Rodrigues Pinto; BARON, Monique Andrade; BENVENUTI, Luiz Alberto; TEIXEIRA, Priscila Camillo; NAVARRO, Isabela Cunha; CABANTOUS, Sandrine; FERREIRA, Frederico Moraes; CANDIDO, Darlan da Silva; GAIOTTO, Fabio Antonio; BACAL, Fernando; POMERANTZEFF, Pablo; SANTOS, Ronaldo Honorato Barros; KALIL, Jorge; CUNHA-NETO, Edecio; CHEVILLARD, Christophe
    Long noncoding RNAs (lncRNAs) modulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels. Dysregulation of the lncRNA known as myocardial infarction-associated transcript (MIAT) has been associated with myocardial infarction. Chagas disease causes a severe inflammatory dilated chronic cardiomyopathy (CCC). We investigated the role of MIAT in CCC. A whole-transcriptome analysis of heart biopsy specimens and formalin-fixed, paraffin-embedded samples revealed that MIAT was overexpressed in patients with CCC, compared with subjects with noninflammatory dilated cardiomyopathy and controls. These results were confirmed in a mouse model. Results suggest that MIAT is a specific biomarker of CCC.
  • article 37 Citação(ões) na Scopus
    Whole-Genome Cardiac DNA Methylation Fingerprint and Gene Expression Analysis Provide New Insights in the Pathogenesis of Chronic Chagas Disease Cardiomyopathy
    (2017) LAUGIER, Laurie; FRADE, Amanda Farage; FERREIRA, Frederico Moraes; BARON, Monique Andrade; TEIXEIRA, Priscila Camillo; CABANTOUS, Sandrine; FERREIRA, Ludmila Rodrigues Pinto; LOUIS, Laurence; RIGAUD, Vagner Oliveira Carvalho; GAIOTTO, Fabio Antonio; BACAL, Fernando; POMERANTZEFF, Pablo; BOCCHI, Edimar; KALIL, Jorge; SANTOS, Ronaldo Honorato Barros; CUNHA-NETO, Edecio; CHEVILLARD, Christophe
    Background. Chagas disease, caused by the protozoan Trypanosoma cruzi, is endemic in Latin America and affects 10 million people worldwide. Approximately 12 000 deaths attributable to Chagas disease occur annually due to chronic Chagas disease cardiomyopathy (CCC), an inflammatory cardiomyopathy presenting with heart failure and arrythmia; 30% of infected subjects develop CCC years after infection. Genetic mechanisms play a role in differential progression to CCC, but little is known about the role of epigenetic modifications in pathological gene expression patterns in CCC patients' myocardium. DNA methylation is the most common modification in the mammalian genome. Methods. We investigated the impact of genome-wide cardiac DNA methylation on global gene expression in myocardial samples from end-stage CCC patients, compared to control samples from organ donors. Results. In total, 4720 genes were differentially methylated between CCC patients and controls, of which 399 were also differentially expressed. Several of them were related to heart function or to the immune response and had methylation sites in their promoter region. Reporter gene and in silico transcription factor binding analyses indicated promoter methylation modified expression of key genes. Among those, we found potassium channel genes KCNA4 and KCNIP4, involved in electrical conduction and arrythmia, SMOC2, involved in matrix remodeling, as well as enkephalin and RUNX3, potentially involved in the increased T-helper 1 cytokine-mediated inflammatory damage in heart. Conclusions. Results support that DNA methylation plays a role in the regulation of expression of pathogenically relevant genes in CCC myocardium, and identify novel potential disease pathways and therapeutic targets in CCC.
  • conferenceObject
    Use of Grafts With Extended Ischemic Time (Above 4 Hours Or More): Analysis of the Experience of the Largest Brazilian Heart Transplant Center, From 2013 to 2022
    (2022) SANTOS, Ronaldo Honorato; GAIOTTO, Fabio A.; STEFFEN, Samuel P.; FILHO, Domingos D. L.; GASPAR, Shirlyne F. D.; BACAL, Fernando; JATENE, Fabio B.