RODRIGO BUENO DE OLIVEIRA
Projetos de Pesquisa
Unidades Organizacionais
LIM/16 - Laboratório de Fisiopatologia Renal, Hospital das Clínicas, Faculdade de Medicina
3 resultados
Resultados de Busca
Agora exibindo 1 - 3 de 3
- The chronic kidney disease outcomes and practice patterns study Brazil (CKDopps-Brazil): Design, data and methodology(2014) OLIVEIRA, Rodrigo Bueno de; LOPES, Antonio Alberto; SESSO, Ricardo; CAMPOS, Ludimila G. de; MARIANI, Laura; LUGON, Jocemir R.; ROBINSON, Bruce M.; PISONI, Ronald L.; PECOITS-FILHO, Roberto F.Introduction: The chronic kidney disease outcomes and practice patterns study (CKDopps) is an international observational, prospective, cohort study involving patients with chronic kidney disease (CKD) stages 3-5 [estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m2, with a major focus upon care during the advanced CKD period (eGFR < 30 ml/min/1.73 m2)]. During a 1-year enrollment period, each one of the 22 selected clinics will enroll up to 60 advanced CKD patients (eGFR < 30 ml/min/1.73 m2 and not dialysis-dependent) and 20 earlier stage CKD patients (eGFR between 30-59 ml/min/1.73 m2). Exclusion criteria: age < 18 years old, patients on chronic dialysis or prior kidney transplant. The study timeline include up to one year for enrollment of patients at each clinic starting in the end of 2013, followed by up to 2-3 years of patient follow-up with collection of detailed longitudinal patient-level data, annual clinic practice-level surveys, and patient surveys. Analyses will apply regression models to evaluate the contribution of patient-level and clinic practice-level factors to study outcomes, and utilize instrumental variable-type techniques when appropriate. Conclusion: Launching in 2013, CKDopps Brazil will study advanced CKD care in a random selection of nephrology clinics across Brazil to gain understanding of variation in care across the country, and as part of a multinational study to identify optimal treatment practices to slow kidney disease progression and improve outcomes during the transition period to end-stage kidney disease.
conferenceObject EFFECTS OF PYROPHOSPHATE DELIVERY IN A PERITONEAL DIALYSIS SOLUTION ON BONE TISSUE OF APOLIPOPROTEIN-E KNOCKOUT MICE WITH CHRONIC KIDNEY DISEASE(2014) BARRETO, Fellype C.; OLIVEIRA, Rodrigo B. De; BENCHITRIT, Joyce; LOUVET, Loic; REZG, Raja; POIROT, Sabrina; JORGETTI, Vanda; DRUEEKE, Tilman B.; RISER, Bruce L.; MASSY, Ziad A.- Effects of pyrophosphate delivery in a peritoneal dialysis solution on bone tissue of apolipoprotein-E knockout mice with chronic kidney disease(2014) BARRETO, Fellype C.; OLIVEIRA, Rodrigo B. de; BENCHITRIT, Joyce; LOUVET, Loic; REZG, Raja; POIROT, Sabrina; JORGETTI, Vanda; DRUEEKE, Tilman B.; RISER, Bruce L.; MASSY, Ziad A.Vascular calcification (VC) is a risk factor for cardiovascular mortality in the setting of chronic kidney disease (CKD). Pyrophosphate (PPi), an endogenous molecule that inhibits hydroxyapatite crystal formation, has been shown to prevent the development of VC in animal models of CKD. However, the possibility of harmful effects of exogenous administration of PPi on bone requires further investigation. To this end, we examined by histomorphometry the bone of CKD mice after intraperitoneal PPi administration. After CKD creation or sham surgery, 10-week-old female apolipoprotein-E knockout (apoE(-/-)) mice were randomized to one non-CKD group or 4 CKD groups (n = 10-35/group) treated with placebo or three distinct doses of PPi, and fed with standard diet. Eight weeks later, the animals were killed. Serum and femurs were sampled. Femurs were processed for bone histomorphometry. Placebo-treated CKD mice had significantly higher values of osteoid volume, osteoid surface and bone formation rate than sham-placebo mice with normal renal function. Slightly higher osteoid values were observed in CKD mice in response to very low PPi dose (OV/BV, O. Th and ObS/BS) and, for one parameter measured, to high PPi dose (O. Th), compared to placebo-treated CKD mice. Treatment with PPi did not modify any other structural parameters. Mineral apposition rates, and other parameters of bone formation and resorption were not significantly different among the treated animal groups or control CKD placebo group. In conclusion, PPi does not appear to be deleterious to bone tissue in apoE(-/-) mice with CKD, although a possible stimulatory PPi effect on osteoid formation may be worth further investigation.