RODRIGO BUENO DE OLIVEIRA
Projetos de Pesquisa
Unidades Organizacionais
LIM/16 - Laboratório de Fisiopatologia Renal, Hospital das Clínicas, Faculdade de Medicina
4 resultados
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Agora exibindo 1 - 4 de 4
- The quest for a better understanding of chronic kidney disease complications: an update on uremic toxins(2014) BARRETO, Fellype Carvalho; STINGHEN, Andréa Emilia Marques; OLIVEIRA, Rodrigo Bueno de; FRANCO, Ana Tereza Barufi; MORENO, Andréa Novais; BARRETO, Daniela Veit; PECOITS-FILHO, Roberto; DRüEKE, Tilman B.; MASSY, Ziad A.Chronic kidney disease is characterized by a progressive reduction of glomerular filtration rate and/or the appearance of proteinuria, and subsequently the progressive retention of organic waste compounds called uremic toxins (UT). Over the last decades, a large number of such compounds have been identified and their effects on organs and tissues, especially the cardiovascular system, has been demonstrated. In this review, we present the current classification of UT, as proposed by the EUTox Group, and the effects of some of the probably most important UTs, such as phosphate, FGF-23, PTH, AGEs, indoxyl sulfate and para-cresyl sulfate. We provide an overview on therapeutic approaches aimed to increase their extracorporeal removal via convective and/or adsorptive strategies and to lower their intestinal production/ absorption via dietetic and pharmacological interventions. The recognition that multiple toxins contribute to the uremia supports the need for new therapeutic targets, with a potentially positive impact on CKD progression and survival.
conferenceObject EFFECTS OF PYROPHOSPHATE DELIVERY IN A PERITONEAL DIALYSIS SOLUTION ON BONE TISSUE OF APOLIPOPROTEIN-E KNOCKOUT MICE WITH CHRONIC KIDNEY DISEASE(2014) BARRETO, Fellype C.; OLIVEIRA, Rodrigo B. De; BENCHITRIT, Joyce; LOUVET, Loic; REZG, Raja; POIROT, Sabrina; JORGETTI, Vanda; DRUEEKE, Tilman B.; RISER, Bruce L.; MASSY, Ziad A.- Effects of pyrophosphate delivery in a peritoneal dialysis solution on bone tissue of apolipoprotein-E knockout mice with chronic kidney disease(2014) BARRETO, Fellype C.; OLIVEIRA, Rodrigo B. de; BENCHITRIT, Joyce; LOUVET, Loic; REZG, Raja; POIROT, Sabrina; JORGETTI, Vanda; DRUEEKE, Tilman B.; RISER, Bruce L.; MASSY, Ziad A.Vascular calcification (VC) is a risk factor for cardiovascular mortality in the setting of chronic kidney disease (CKD). Pyrophosphate (PPi), an endogenous molecule that inhibits hydroxyapatite crystal formation, has been shown to prevent the development of VC in animal models of CKD. However, the possibility of harmful effects of exogenous administration of PPi on bone requires further investigation. To this end, we examined by histomorphometry the bone of CKD mice after intraperitoneal PPi administration. After CKD creation or sham surgery, 10-week-old female apolipoprotein-E knockout (apoE(-/-)) mice were randomized to one non-CKD group or 4 CKD groups (n = 10-35/group) treated with placebo or three distinct doses of PPi, and fed with standard diet. Eight weeks later, the animals were killed. Serum and femurs were sampled. Femurs were processed for bone histomorphometry. Placebo-treated CKD mice had significantly higher values of osteoid volume, osteoid surface and bone formation rate than sham-placebo mice with normal renal function. Slightly higher osteoid values were observed in CKD mice in response to very low PPi dose (OV/BV, O. Th and ObS/BS) and, for one parameter measured, to high PPi dose (O. Th), compared to placebo-treated CKD mice. Treatment with PPi did not modify any other structural parameters. Mineral apposition rates, and other parameters of bone formation and resorption were not significantly different among the treated animal groups or control CKD placebo group. In conclusion, PPi does not appear to be deleterious to bone tissue in apoE(-/-) mice with CKD, although a possible stimulatory PPi effect on osteoid formation may be worth further investigation.
- French-Brazilian school of nephrology(2012) OLIVEIRA, Rodrigo Bueno de; CRUZ, Jenner; DRUEEKE, Tilman Bernhard; MASSY, ZiadThe recent history of French and Brazilian medicine goes back to the first decades of the xixth century. As regards nephrology, the first links were established starting in the 1950s of the xxth century. Over the past 60 years, the scientific production of the Franco-Brazilian school of nephrology totalized more than a thousand scientific papers and created a new generation of more than two hundred disciples, formed in Brazil by nephrologists who had completed their studies in France. In this article, we would like to memorize the successive exchanges between French and Brazilian physicians, mainly in the field of nephrology.