RODRIGO BUENO DE OLIVEIRA
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LIM/16 - Laboratório de Fisiopatologia Renal, Hospital das Clínicas, Faculdade de Medicina
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- Exercise training, creatine supplementation, and bone health in ovariectomized rats(2015) MURAI, I. H.; ROSCHEL, H.; PABIS, L. V. S.; TAKAYAMA, L.; OLIVEIRA, R. B. de; PEREIRA, R. T. dos Santos; DANTAS, W. S.; PEREIRA, R. M. R.; JORGETTI, V.; BALLESTER, R. Y.; GUALANO, B.Evidence suggests that creatine may have some beneficial effects on bone. The study aimed to investigate the effects of exercise alone or combined with creatine on bone health in ovariectomized rats. Findings show that exercise, but not creatine, has an important role in improving bone health. Introduction The aim of this study was to investigate the effects of exercise training alone or combined with creatine supplementation on bone health parameters in ovariectomized rats. Methods Wistar rats were randomly allocated into one of five groups: (i) sham-operated, (ii) ovariectomized non-trained placebo-supplemented, (iii) ovariectomized non-trained creatine- supplemented, (iv) ovariectomized exercise-trained placebo-supplemented, and (v) ovariectomized exercise-trained creatine-supplemented. Downhill running training and/or creatine supplementation (300 mg/kg body weight) were administered for 12 weeks. Bone mineral content (BMC), bone mineral density (BMD), and biomechanical and histomorphometric parameters were assessed. Results No interaction effects were observed for BMC and BMD at whole body, femur, and lumbar spine (p>0.05). Importantly, a main effect of training was detected for whole body BMC and BMD (p=0.003 and p<0.001, respectively), femoral BMC and BMD (p=0.005 and p<0.001, respectively), and lumbar spine BMC and BMD (p<0.001 and p<0.001, respectively), suggesting that the trained animals had higher bone mass, irrespective of creatine supplementation. Main effects of training were also observed for maximal load (p< 0.001), stiffness (p<0.001), and toughness (p=0.046), indicating beneficial effects of exercise training on bone strength. Neither a main effect of supplementation nor an interaction effect was detected for biomechanical parameters (p>0.05). No main or interaction effects were observed for any of the histomorphometric parameters evaluated (p>0.05). Conclusions Exercise training, but not creatine supplementation, attenuated ovariectomy-induced bone loss in this rat model.
- THE CLINICAL IMPACT OF TOTAL PARATHYROIDECTOMY WITH AUTO TRANSPLANTATION IN REFRACTORY SECONDARY HYPERPARATHYROIDISM(2015) ALBUQUERQUE, Roxana F. C. de; MARTIN, Rita C.; MASSONI, Ledo; NASCIMENTO, Climerio do; ARAP, Sergio S.; MONTENEGRO, Fabio L. M.; MOYSES, Rosa M. A.; JORGETTI, Vanda; OLIVEIRA, Rodrigo B. de
- Is urinary density an adequate predictor of urinary osmolality?(2015) SOUZA, Ana Carolina P.; ZATZ, Roberto; OLIVEIRA, Rodrigo B. de; SANTINHO, Mirela A. R.; RIBALTA, Marcia; ROMAO JR., Joao E.; ELIAS, Rosilene M.Background: Urinary density (UD) has been routinely used for decades as a surrogate marker for urine osmolality (U-osm). We asked if UD can accurately estimate U-osm both in healthy subjects and in different clinical scenarios of kidney disease. Methods: UD was assessed by refractometry. U-osm was measured by freezing point depression in spot urines obtained from healthy volunteers (N = 97) and in 319 inpatients with acute kidney injury (N = 95), primary glomerulophaties (N = 118) or chronic kidney disease (N = 106). Results: UD and U-osm correlated in all groups (p < 0.05). However, a wide range of U-osm values was associated with each UD value. When UD was <= 1.010, 28.4% of samples had U-osm above 350 mOsm/kg. Conversely, in 61.6% of samples with UD above 1.020, U-osm was below 600 mOsm/kg. As expected, U-osm exhibited a strong relationship with serum creatinine (S-creat), whereas a much weaker correlation was found between UD and Screat. Conclusion: We found that UD is not a substitute for U-osm. Although UD was significantly correlated with U-osm, the wide dispersion makes it impossible to use UD as a dependable clinical estimate of U-osm. Evaluation of the renal concentrating ability should be based on direct determination of U-osm.