RAQUEL LEAO ORFALI
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/56 - Laboratório de Investigação em Dermatologia e Imunodeficiências, Hospital das Clínicas, Faculdade de Medicina
LIM/56 - Laboratório de Investigação em Dermatologia e Imunodeficiências, Hospital das Clínicas, Faculdade de Medicina
5 resultados
Resultados de Busca
Agora exibindo 1 - 5 de 5
- Evaluating chronic pruritus prevalence, characteristics and effects on atopic dermatitis patients from a referral university hospital in Sao Paulo, Brazil: a cross-sectional study(2023) SOARES, Georgia Biazus; ORFALI, Raquel Leao; AVERBACH, Beatriz Lacerda; YOSIPOVITCH, Gil; AOKI, Valeria
conferenceObject Impact of climate change on atopic dermatitis: A systematic search and review by the International Eczema Council(2023) WANG, S.; STEFANOVIC, N.; ORFALI, R. L.; AOKI, V.; BROWN, S.; DHAR, S.; EICHENFIELD, L. F.; FLOHR, C.; HA, A.; MORA, C.; MURASE, J.; ROSENBACH, M.; THYSSEN, J.; WEI, M. L.; IRVINE, A. D.; ABUABARA, K.- Atopic Dermatitis in Latin America: Considerations on Epidemiology, Clinical and Laboratory Features, Ethnic/Racial Variations, and Therapeutic Management(2023) SOARES, Georgia Biazus; ORFALI, Raquel Leao; AVERBACH, Beatriz Lacerda; YOSIPOVITCH, Gil; AOKI, ValeriaLatin America (LA) encompasses about 8.5% of the world's population, exhibits ethnic/racial heterogeneity and social inequality. We hereby present a 20-year literature review (2004-2023) on epidemiology, diagnosis, clinical and laboratory features, quality of life and management of atopic dermatitis (AD) in LA. Highest AD prevalence for children aged 6-7 years was reported in Ecuador (22.5%) and Colombia (20.9%), for adolescents in Colombia (24.6%) and for all ages, in Brazil (20.1%). Regions with a predominantly Black population in LA varied significantly, ranging from 4.4% in Northern Brazil to 10.1% in Cuba, indicating genetic variation among African subgroups. Filaggrin loss-of-function mutations showed variants seen in Europeans in 9.3% of Chilean patients and studies in Brazil revealed impaired expression of filaggrin and claudin-1 in the skin but increased expression in conjunctival epithelia of AD patients. The most reported AD features included erythema, pruritus, and dry skin, with marked lichenification. Severe pruritus was reported by 54.4% of patients and a high impact on quality of life was detected in 50% of adults with AD. In Brazilian referral hospitals, 65.6% of patients were classified as having severe AD, and 56% had one or more hospitalizations during their lifetime, indicating a need for better disease control. Diagnosing AD is challenging due to broad clinical features, ethnoracial variations and lack of universal diagnostic criteria. Furthermore, lack of physician training, barriers to medication access, and socioeconomic inequalities hinder effective disease management in LA.
- The (one-year) prevalence of atopic dermatitis in Brazil: A population-based telephone survey(2023) MIOT, Helio Amante; AOKI, Valeria; ORFALI, Raquel Leao; SOLE, Dirceu; MALLOZI, Marcia Carvalho; RODRIGUES, Tatiane C.; SILVERBERG, Jonathan I.
conferenceObject A LARGE LANGUAGE MODEL ARTIFICIAL INTELLIGENCE FOR PATIENT QUERIES IN ATOPIC DERMATITIS(2023) SULEJMANI, Pranvera; NEGRIS, Olivia; AOKI, Valeria; CHU, Chia-Yu; EICHENFIELD, Lawrence; MISERY, Laurent; MOSCA, Ana; ORFALI, Raquel Leao; AROMAN, Marketa Saint; STALDER, Jean-Francois; TRZECIAK, Magdalena; WOLLENBERG, Andreas; LIO, Peter