CONSUELO JUNQUEIRA RODRIGUES
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Ortopediae Traumatologia, Faculdade de Medicina - Docente
LIM/02 - Laboratório de Anatomia Médico-Cirúrgica, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/02 - Laboratório de Anatomia Médico-Cirúrgica, Hospital das Clínicas, Faculdade de Medicina - Líder
3 resultados
Resultados de Busca
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- Study of 1550nm Erbium Glass Laser Fractional non-ablative treatment of photoaging: comparative clinical effects, histopathology, electron microscopy and immunohistochemistry(2023) SICA, Regia Celli Patriota de; RODRIGUES, Consuelo J.; MARIA, Durvanei Augusto; CUCE, Luis CarlosWe, the Editors and Publisher of the Journal of Cosmetic and Laser Therapy have retracted the following article:Regia Celli Patriota de Sica, Consuelo J. Rodrigues, Durvanei Augusto Maria & Luis Carlos Cuce (2016) Study of 1550nm Erbium Glass Laser Fractional non-ablative treatment of photoaging: Comparative clinical effects, histopathology, electron microscopy and immunohistochemistry, Journal of Cosmetic and Laser Therapy, DOI: 10.1080/14764172.2016.1191647Since publication of the accepted author version, authors have not responded to requests to submit corrections and approve proofs, preventing the final publication of the Version of Record (VoR). Authors have also not provided completed copyright forms.We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as 'Retracted'.
- Study of 1550-nm Erbium glass laser fractional non-ablative treatment of photoaging: Comparative clinical effects, histopathology, electron microscopy, and immunohistochemistry(2016) SICA, Regia Celli Patriota de; RODRIGUES, Consuelo J.; MARIA, Durvanei Augusto; CUCE, Luis CarlosBackground: Non-ablative fractional lasers have been effectively used in skin rejuvenation. Objectives: This study evaluates the efficacy of 1550-nm Erbium glass laser for facial rejuvenation through the correlation of clinical evaluation and histopathology, immunohistochemistry, and electron microscopy analysis. Methods: Fifteen subjects (average age: 56.4 years, skin types: I-III) with mild-to-moderate photodamage were submitted to biopsies and 3 facial treatments. Data from the photo assessments and the clinical improvement were analyzed 4 months after the treatments. The biopsy skins were fixed in neutral buffered formalin before being embedded in paraffin, and stained with hematoxylin and eosin. The histomorphometric quantification of collagen and elastic fibers; intercellular adhesion molecule 1 expression by immunohistochemistry; and analysis of cell cycle phases, the electrical potential of the mitochondrial, and interleukin (IL)-1, CD34, transforming growth factor (TGF)-beta, and caspase-3 expression by flow cytometry were analyzed. Results: After 4 months of treatment, collagen fibers had increased by 6.68%, and intercellular adhesion molecule 1 (ICAM-1) had increased by 4.47% in vessel area. Significantly enhanced IL-1 and TGF-beta receptor expressions were identified after treatment. Proliferative responses and non-apoptosis-dependent caspase-3 activity were both observed in the cell after dermal treatment. Conclusion: The histopathology, immunohistochemistry, and electron microscopy showed an improvement compatible to the clinical effectiveness after 4 months.
- Quantitative evaluation of collagen and elastic fibers after intense pulsed light treatment of mouse skin(2018) FAUCZ, Luciana L.; WILL, Sonia E.; RODRIGUES, Consuelo J.; HESSE, Henrique; MORAES, Angelina C.; MARIA, Durvanei A.Background and ObjectiveThe aging of human skin includes intrinsic aging and photo-aging, which are characterized by a decrease in collagen and the deposition of abnormal elastic fibers. Intense pulsed light (IPL) sources are widely used in medicine to treat various cosmetic problems, including photo-damaged skin. Few studies have examined the microscopic changes produced by IPL. The objective of this study was to quantitatively evaluate the effects of IPL on collagen and elastic fibers in mice. Materials and MethodsForty female BALB/c mice were divided into four subgroups. Group 1 was the control group (n=10), and groups 2, 3, and 4 were treatment groups (n=10 in each group). Group 2 received one treatment, group 3 received two treatments, and group 4 received three treatments every 2 weeks. Skin tissue was obtained from irradiated areas 24 hours after the last treatment in each mouse. Collagen fibers were identified using the picrosirius red method. Elastic fibers were marked by Weigert-oxone stain. All samples were analyzed and quantified by a light microscope using analyzer system images. ResultsGroup 4, which received three IPL treatments, showed significant quantitative increases in both collagen fibers (P<0.05) and elastic fibers (P<0.01). Collagen fibers demonstrated a better parallel distribution in relation to the epidermis. ConclusionIPL treatment significantly increased the number of collagen and elastic fibers within the dermis and improved the parallel distribution of collagen fibers in relation to the epidermis. These results were evident after three IPL treatments. Lasers Surg. Med. 50:644-650, 2018. (c) 2018 Wiley Periodicals, Inc.