DANIEL CIAMPI ARAUJO DE ANDRADE
Projetos de Pesquisa
Unidades Organizacionais
LIM/62 - Laboratório de Fisiopatologia Cirúrgica, Hospital das Clínicas, Faculdade de Medicina - Líder
9 resultados
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Agora exibindo 1 - 9 de 9
- Brazilian research on noninvasive brain stimulation applied to health conditions(2021) SA, Katia Nunes; VENAS, Gabriel; SOUZA, Mayara Pinheiro de; ANDRADE, Daniel Ciampi de; BAPTISTA, Abrahao FontesBackground: Brazil has a top position regarding scientific production on noninvasive neuromodulation worldwide. Knowledge of scientometric phenomena involving Brazilian researchers who produce science on this theme may aid confidence in Brazilian clinical and research professionals. Objective: To investigate the scenario of research on the theme of noninvasive neuromodulation in Brazil. Methods: This was a scientometric study for mapping scientific production on this subject involving network phenomena, the professions of researchers, institutional affiliation, main research unit, total number of scientific articles on noninvasive neuromodulation published in journals, research sub-area and year of obtaining the PhD title. Public data from Lattes Platform curricula vitae and from VOSViewer(C) were used. Results: A total of 54 Brazilian researchers were identified, of whom 16 are research productivity fellows. Most of them are linked to institutions in southeastern Brazil, involving the professions of biology, biochemistry, physical education, physiotherapy, speech therapy, gerontology, medicine and psychology, with 1175 articles published in journals. These studies involve experimental animal and human models to account for mechanisms, observational studies, case reports, randomized clinical trials, systematic reviews, meta-analyses, product and process development, computer modeling and guidelines. Conclusions: Brazil occupies a prominent place in the world scenario of research on noninvasive neuromodulation, which is used by different professions for treatment of brain dysfunctions, with a trend towards expansion to other fields.
article 26 Citação(ões) na Scopus The assessment and management of pain in the demented and non-demented elderly patient(2011) ANDRADE, Daniel Ciampi de; FARIA, Jose Weber Vieira de; CARAMELLI, Paulo; ALVARENGA, Luciana; GALHARDONI, Ricardo; SIQUEIRA, Silvia R. D.; YENG, Lin T.; TEIXEIRA, Manoel JacobsenPersistent pain is a frequent health problem in the elderly. Its prevalence ranges from 45% to 80%. Chronic diseases, such as depression, cardiovascular disease, cancer and osteoporosis have a higher prevalence in aged individuals and increase the risk of developing chronic pain. The presence of pain is known to be associated with sleep disorders in these patients, as well as functional impairment, decreased sociability and greater use of the health system, with consequent increase in costs. Alzheimer's disease patients seem to have a normal pain discriminative capacity and they may probably have weaker emotional and affective experience of pain when compared to other types of dementia. Many patients have language deficits and thus cannot properly describe its characteristics. In more advanced cases, it becomes even difficult to determine whether pain is present or not. Therefore, the evaluation of these patients should be performed in a systematic way. There are three ways to measure the presence of pain: by direct questioning (self-report), by direct behavioral observation and by interviews with caregivers or informants. In recent years, many pain scales and questionnaires have been published and validated specifically for the elderly population. Some are specific to patients with cognitive decline, allowing pain evaluation to be conducted in a structured and reproducible way. The next step is to determine the type of painful syndrome and discuss the bases of the pharmacological management, the use of multiple medications and the presence of comorbidities demand the use of smaller doses and impose contra-indications against some drug classes. A multiprofessional approach is the rule in the management of these patients.- Echogenicity of the substantia nigra region in Parkinson's disease(2012) BAR-SENG-SHU, Edson; ALMEIDA, Kelson James; ANDRADE, Daniel Ciampi de; FONOFF, Erich Talamoni; TEIXEIRA, Manoel Jacobsen; BARBOSA, Egberto Reis
- Prevalence of chronic pain in a metropolitan area of a developing country: a population-based study(2016) FERREIRA, Karine A. S. Leao; BASTOS, Telma Regina P. D.; ANDRADE, Daniel Ciampi de; SILVA, Aline Medeiros; APPOLINARIO, Jose Carlos; TEIXEIRA, Manoel Jacobsen; LATORRE, Maria do Rosario Dias de OliveiraObjective: To estimate the prevalence of chronic pain (CP) in the adult population living in the city of Sao Paulo, Brazil, and to identify factors associated with CP in developing countries. Methods: A cross-sectional study using a computer-assisted telephone interview in a two-stage stratified sample of adults living in households. Results: 2,446 subjects were interviewed. The mean age was 39.8 years old. The majority was female and 42.7% had less than 10 years of education. The prevalence of CP was 28.1%. The independent factors associated with CP were female gender (OR = 2.0; p < 0.001), age older than 65 years (OR = 1.4; p = 0.019) and less than 15 years of education (OR = 1.3-1.6; p < 0.04). Conclusions: The prevalence of CP was high and similar to that which has been reported in developed countries. These results raise awareness about CP and may potentially help clinicians and policy makers to design better health care programs for CP treatment in these populations.
- Liposomal topical capsaicin in post-herpetic neuralgia: a safety pilot study(2015) TEIXEIRA, Manoel Jacobsen; MENEZES, Luciana Mendes Bahia; SILVA, Valquiria; GALHARDONI, Ricardo; SASSON, Jose; OKADA, Massako; DUARTE, Kleber Paiva; YENG, Lin T.; ANDRADE, Daniel Ciampi deTopical treatments have gained popularity for general use as an adjunct to systemic drugs in neuropathic pain, but their use produces variable clinical results and local adverse events. Objective: To evaluate the safety and analgesic effect of a formulation of liposomal capsaicin (LC) (0.025%) in patients with post herpetic neuralgia (PHN). Method: Patients who remained symptomatic after first-and second-line treatment were randomized to receive LC for six weeks in a placebo-controlled, crossover design study. Clinical assessment was performed at baseline, in the second, fourth and sixth week of treatment. Results: Thirteen patients completed both treatment periods. Visual Analog Scale (VAS) was significantly decreased after the end of the study (p = 0.008), however the effect of treatment was not significant (p = 0.076). There was no difference on global impression of change and other pain characteristics. LC was safe and well tolerated. However, at the concentration used, its analgesic effects were marginal and not significant.
- Pharmacological treatment of central neuropathic pain: consensus of the Brazilian Academy of Neurology(2020) OLIVEIRA, Rogerio Adas Ayres de; BAPTISTA, Abrahao Fontes; SA, Katia Nunes; BARBOSA, Luciana Mendonca; NASCIMENTO, Osvaldo Jose Moreira do; LISTIK, Clarice; MOISSET, Xavier; TEIXEIRA, Manoel Jacobsen; ANDRADE, Daniel Ciampi deBackground: Central neuropathic pain (CNP) is often refractory to available therapeutic strategies and there are few evidence-based treatment options. Many patients with neuropathic pain are not diagnosed or treated properly. Thus, consensus-based recommendations, adapted to the available drugs in the country, are necessary to guide clinical decisions. Objective: To develop recommendations for the treatment of CNP in Brazil. Methods: Systematic review, meta-analysis, and specialists opinions considering efficacy, adverse events profile, cost, and drug availability in public health. Results: Forty-four studies on CNP treatment were found, 20 were included in the qualitative analysis, and 15 in the quantitative analysis. Medications were classified as first-, second-, and third-line treatment based on systematic review, meta-analysis, and expert opinion. As first-line treatment, gabapentin, duloxetine, and tricyclic antidepressants were included. As second-line, venlafaxine, pregabalin for CND secondary to spinal cord injury, lamotrigine for CNP after stroke, and, in association with first-line drugs, weak opioids, in particular tramadol. For refractory patients, strong opioids (methadone and oxycodone), cannabid iol/delta-9-tetrahyd rocannabi nol, were classified as third-line of treatment, in combination with first or second-line drugs and, for central nervous system (CNS) in multiple sclerosis, dronabinol. Conclusions: Studies that address the treatment of CNS are scarce and heterogeneous, and a significant part of the recommendations is based on experts opinions. The CNP approach must be individualized, taking into account the availability of medication, the profile of adverse effects, including addiction risk, and patients' comorbidities.
- Cannabinoids in Neurology - Position paper from Scientific Departments from Brazilian Academy of Neurology(2021) BRUCKI, Sonia Maria Dozzi; ADONI, Tarso; ALMEIDA, Carlos Mauricio Oliveira; ANDRADE, Daniel Ciampi de; ANGHINAH, Renato; BARBOSA, Luciana Mendonca; BAZAN, Rodrigo; CARVALHO, Alzira Alves de Siqueira; CARVALHO, William; CHRISTO, Paulo Pereira; COLETTA, Marcus Della; CONFORTO, Adriana Bastos; CORREA-NETO, Ylmar; ENGELHARDT, Eliasz; FRANCA JUNIOR, Marcondes Cavalcante; FRANCO, Clelia; GLEHN, Felipe Von; GOMES, Helio Rodrigues; HOULY, Caroline Gomes de Barros; KAUP, Alexandre Ottoni; KOWACS, Fernando; KANASHIRO, Aline; LOPES, Victor Goncalves; MAIA, Debora; MANREZA, Maria; MARTINEZ, Alberto Rolim Muro; MARTINEZ, Sandra Cristina Goncalves; NADER, Saulo Nardy; NEVES, Luciana de Oliveira; OKAMOTO, Ivan Hideyo; OLIVEIRA, Rogerio Adas Ayres de; PEIXOTO, Fabiano de Melo; PEREIRA, Cristiana Borges; SABA, Roberta Arb; SAMPAIO, Leticia Pereira de Brito; SCHILLING, Lucas Porcello; SILVA, Marcus Tulius Teixeira; SILVA, Emanuelle Roberta; SMID, Jerusa; SOARES, Cristiane Nascimento; SOBREIRA-NETO, Manoel; SOUSA, Nise Alessandra de Carvalho; SOUZA, Leonardo Cruz de; TEIVE, Helio Afonso Ghizoni; TERRA, Vera Cristina; VALE, Matheus; VIEIRA, Vitor Mendes Grise; ZANOTELI, Edmar; PRADO, GilmarCannabinoids comprehend endocannabinoids, phytocannabinoids, and synthetic cannabinoids, with actions both in the central and peripherical nervous systems. A considerable amount of publications have been made in recent years, although cannabis has been known for over a thousand years. Scientific Departments from the Brazilian Academy of Neurology described evidence for medical use in their areas. Literature is constantly changing, and possible new evidence can emerge in the next days or months. Prescription of these substances must be discussed with patients and their families, with knowledge about adverse events and their efficacy.
- Deep brain stimulation treatment in dystonia: a bibliometric analysis(2020) LISTIK, Clarice; LISTIK, Eduardo; CURY, Rubens Gisbert; BARBOSA, Egberto Reis; TEIXEIRA, Manoel Jacobsen; ANDRADE, Daniel Ciampi deBackground: Dystonia is a heterogeneous disorder that, when refractory to medical treatment, may have a favorable response to deep brain stimulation (DBS).A practical way to have an overview of a research domain is through a bibliometric analysis, as it makes it more accessible for researchers and others outside the field to have an idea of its directions and needs. Objective: To analyze the 100 most cited articles in the use of DBS for dystonia treatment in the last 30 years. Methods: The research protocol was performed in June 2019 in Elsevier's Scopus database, by retrieving the most cited articles regarding DBS in dystonia. We analyzed authors, year of publication, country, affiliation, and targets of DBS. Results: Articles are mainly published in Movement Disorders (19%), Journal of Neurosurgery (9%), and Neurology (9%). European countries offer significant contributions (57% of our sample). France (192.5 citations/paper) and Germany (144.1 citations/paper) have the highest citation rates of all countries. The United States contributes with 31% of the articles, with 129.8 citations/paper. The publications are focused on General outcomes (46%), followed by Long-term outcomes (12.5%), and Complications (11%), and the leading type of dystonia researched is idiopathic or inherited, isolated, segmental or generalized dystonia, with 27% of articles and 204.3 citations/ paper. Conclusions: DBS in dystonia research is mainly published in a handful of scientific journals and focused on the outcomes of the surgery in idiopathic or inherited, isolated, segmental or generalized dystonia, and with grobus pallidus internus as the main DBS target.
- High prevalence of neuropathic pain in the hand of patients with traumatic brachial plexus injury: a cross-sectional study(2016) SANTANA, Marcus V. B.; BINA, Mauro T.; PAZ, Matheus G.; SANTOS, Scheila N.; TEIXEIRA, Manoel J.; RAICHER, Irina; MARTINS, Jose V.; ANDRADE, Daniel C. Araujo; BAPTISTA, Abrahao F.To describe the pain profile of patients with traumatic brachial plexus injury. Methods: We enrolled 65 patients with traumatic brachial plexus injury. The Douleur Neuropathique 4 questionnaire was used to classify pain and the SF-36 was used to evaluate quality of life. Results: The patients with traumatic brachial plexus injury were predominantly young male victims of motorcycle accidents. Pain was present in 75.4% of the individuals and 79% presented with neuropathic pain, mostly located in the hands (30.41%). The use of auxiliary devices (p = 0.05) and marital status (p = 0.03) were both independent predictors of pain. Pain also impacted negatively on the quality of life (p = 0.001). Conclusions: Pain is frequent in patients with traumatic brachial plexus injury. Despite the peripheral nervous system injury, nociceptive pain is not unusual. Pain evaluation, including validated instruments, is essential to guide optimal clinical management of patients with the condition.