TOMOCO WATANABE
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Radiologia, Faculdade de Medicina
LIM/43 - Laboratório de Medicina Nuclear, Hospital das Clínicas, Faculdade de Medicina
LIM/43 - Laboratório de Medicina Nuclear, Hospital das Clínicas, Faculdade de Medicina
3 resultados
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- Clinical and Dosimetric Variables Related to Outcome After Treatment of Graves' Disease With 550 and 1110 MBq of I-131(2015) SAPIENZA, Marcelo Tatit; COURA-FILHO, George Barberio; WILLEGAIGNON, Jose; WATANABE, Tomoco; DUARTE, Paulo Schiavom; BUCHPIGUEL, Carlos AlbertoTherapy of Graves' hyperthyroidism (HTG) with I-131 is still mostly performed on an empirical basis. The present study was carried out to evaluate clinical and dosimetric variables associated with outcome in HTG therapy, which could contribute to planning and defining the most appropriate activity to be administered. Methods Patients with HTG were randomly assigned to therapy with 555 MBq (15mci) or 1110 MBq (30 mCi) of I-131. Estimation of thyroid radiation absorbed dose was made according to MIRD methodology. Success was defined as clinical/laboratory euthyroidism or hypothyroidism one year after therapy. The association between clinical, laboratory, and dosimetric variables with 1-year outcome was measured using bivariate analysis, followed by logistic regression. Results Ninety-one patients included completed the follow-up. Therapeutic success was observed in 77 (84.6%) of them, in a greater proportion when 1110 MBq of I-131 was administered as compared with 550 MBq (94.8% vs 77.4%, P = 0.02). Besides administered activity, multivariate analysis indicated that outcome was related to patient age and gland mass. A higher therapeutic success rate was achieved with doses greater than 300 Gy as compared with doses less than 300 Gy (89% vs 60%, P = 0.01). Conclusion Administered activity, age, and gland mass were related to the outcome. Radiation absorbed dose, although not significant according to multivariate analysis, may be used as a quantitative parameter in therapy planning, with a target dose of 300 Gy. In cases where a rapid and efficient response to radioiodine treatment is required, adoption of a simplified protocol employing high activities is justified.
article 3 Citação(ões) na Scopus Correlação entre volume tireoidiano determinado pelo método de ultrassonografia versus cintilografia e sua implicação em cálculos dosimétricos na terapia com radioiodo na doença de Graves(2011) VIEIRA, Lucas de Oliveira; KUBO, Rodrigo; SAPIENZA, Marcelo Tatit; WILLEGAIGNON, Jose; CHAMMAS, Maria Cristina; COURA-FILHO, George Barberio; ONO, Carla Rachel; WATANABE, Tomoco; SADO, Heitor Naoki; BUCHPIGUEL, Carlos AlbertoIntroduction: Graves disease (GD) is the most common cause of hiperthyroidism, and the most common treatment options are surgery, antithyroid drugs and radioiodine therapy. In radiodosimetric calculations to determine radioiodine dosage it is possible to use thyroid volume estimatives based on ultrasound or scintigraphy. Objective: The present study aimed to correlate these methodologies emphasizing volume estimatives and dosimetric implications. Subjects and methods: Were included 103 patients with GD diagnosis and indication of radioiodine treatment. They were submitted to thyroid ultrasound and thyroid scintigraphy. Results and conclusions: Good correlation between both methods was observed, although scintigraphy systematically obtained greater volumes than ultrasound implying in lower estimatives of absorbed dose when scintigraphy is used. Arq Bras Endocrinol Metab. 2011;55(9):696-700- Concordance Between Whole-Body Scintigraphy In-111-Octreotide and Tc-99m-Sestamibi Uptake in the Detection of Four Tumor-Induced Osteomalacia Cases(2014) FERRAZ, Marcela Paula; WATANABE, Tomoco; SADO, Heitor Naoki; ONO, Carla Rachel; BUCHPIGUEL, Carlos Alberto; CORREA, Pedro Henrique Silveira; MARTIN, Regina Matsunaga