CARLOS EDUARDO ROCHITTE
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/64, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/64, Hospital das Clínicas, Faculdade de Medicina - Líder
2 resultados
Resultados de Busca
Agora exibindo 1 - 2 de 2
- Cardiovascular Magnetic Resonance for Patients With COVID-19(2022) PETERSEN, Steffen E.; FRIEDRICH, Matthias G.; LEINER, Tim; ELIAS, Matthew D.; FERREIRA, Vanessa M.; FENSKI, Maximilian; FLAMM, Scott D.; FOGEL, Mark; GARG, Ria; HALUSHKA, Marc K.; HAYS, Allison G.; KAWEL-BOEHM, Nadine; KRAMER, Christopher M.; NAGEL, Eike; NTUSI, Ntobeko A. B.; OSTENFELD, Ellen; PENNELL, Dudley J.; RAISI-ESTABRAGH, Zahra; REEDER, Scott B.; ROCHITTE, Carlos E.; STAREKOVA, Jitka; SUCHA, Dominika; TAO, Qian; SCHULZ-MENGER, Jeanette; BLUEMKE, David A.COVID-19 is associated with myocardial injury caused by ischemia, inflammation, or myocarditis. Cardiovascular magnetic resonance (CMR) is the noninvasive reference standard for cardiac function, structure, and tissue composition. CMR is a potentially valuable diagnostic tool in patients with COVID-19 presenting with myocardial injury and evidence of cardiac dysfunction. Although COVID-19-related myocarditis is likely infrequent, COVID-19-related cardiovascular histopathology findings have been reported in up to 48% of patients, raising the concern for long-term myocardial injury. Studies to date report CMR abnormalities in 26% to 60% of hospitalized patients who have recovered from COVID-19, including functional impairment, myocardial tissue abnormalities, late gadolinium enhancement, or pericardial abnormalities. In athletes post-COVID-19, CMR has detected myocarditis-like abnormalities. In children, multisystem inflammatory syndrome may occur 2 to 6 weeks after infection; associated myocarditis and coronary artery aneurysms are evaluable by CMR. At this time, our understanding of COVID-19-related cardiovascular involvement is incomplete, and multiple studies are planned to evaluate patients with COVID-19 using CMR. In this review, we summarize existing studies of CMR for patients with COVID-19 and present ongoing research. We also provide recommendations for clinical use of CMR for patients with acute symptoms or who are recovering from COVID-19. Crown
- Comprehensive myocardial characterization using cardiac magnetic resonance associates with outcomes in low gradient severe aortic stenosis(2022) FUKUI, Miho; ANNABI, Mohamed-Salah; ROSA, Vitor E. E.; RIBEIRO, Henrique B.; I, Larissa Stanberry; CLAVEL, Marie-Annick; RODES-CABAU, Josep; TARASOUTCHI, Flavio; SCHELBERT, Erik B.; BERGLER-KLEIN, Jutta; BARTKO, Philipp E.; DONA, Carolina; MASCHERBAUER, Julia; DAHOU, Abdellaziz; ROCHITTE, Carlos E.; PIBAROT, Philippe; CAVALCANTE, Joao L.Aims This study sought to compare cardiac magnetic resonance (CMR) characteristics according to different flow/gradient patterns of aortic stenosis (AS) and to evaluate their prognostic value in patients with low-gradient AS. Methods and results This international prospective multicentric study included 147 patients with low-gradient moderate to severe AS who underwent comprehensive CMR evaluation of left ventricular global longitudinal strain (LVGLS), extracellular volume fraction (ECV), and late gadolinium enhancement (LGE). All patients were classified as followings: classical low-flow low-gradient (LFLG) [mean gradient (MG) < 40 mmHg and left ventricular ejection fraction (LVEF) < 50%]; paradoxical LFLG [MG < 40 mmHg, LVEF >= 50%, and stroke volume index (SVi) < 35 ml/m(2)]; and normal-flow low-gradient (MG < 40 mmHg, LVEF >= 50%, and SVi >= 35 ml/m(2)). Patients with classical LFLG (n = 90) had more LV adverse remodelling including higher ECV, and higher LGE and volume, and worst LVGLS. Over a median follow-up of 2 years, 43 deaths and 48 composite outcomes of death or heart failure hospitalizations occurred. Risks of adverse events increased per tertile of LVGLS: hazard ratio (HR) = 1.50 [95% CI, 1.02-2.20]; P = 0.04 for mortality; HR = 1.45 [1.01-2.09]; P < 0.05 for composite outcome; per tertile of ECV, HR = 1.63 [1.07-2.49]; P = 0.02 for mortality; HR = 1.54 [1.02-2.33]; P = 0.04 for composite outcome. LGE presence also associated with higher mortality, HR = 2.27 [1.01-5.11]; P < 0.05 and composite outcome, HR = 3.00 [1.16-7.73]; P = 0.02. The risk of mortality and the composite outcome increased in proportion to the number of impaired components (i.e. LVGLS, ECV, and LGE) with multivariate adjustment. Conclusions In this international prospective multicentric study of low-gradient AS, comprehensive CMR assessment provides independent prognostic value that is cumulative and incremental to clinical and echocardiographic characteristics.