CARLOS EDUARDO ROCHITTE
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/64, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/64, Hospital das Clínicas, Faculdade de Medicina - Líder
19 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 19
- Dipyridamole stress myocardial perfusion by computed tomography in patients with left bundle branch block(2015) CABEDA, Estevan Vieira; FALCAO, Andrea Maria Gomes; SOARES JR., Jose; ROCHITTE, Carlos Eduardo; NOMURA, Cesar Higa; AVILA, Luiz Francisco Rodrigues; PARGA, Jose RodriguesBackground: Functional tests have limited accuracy for identifying myocardial ischemia in patients with left bundle branch block (LBBB). Objective: To assess the diagnostic accuracy of dipyridamole-stress myocardial computed tomography perfusion (CTP) by 320-detector CT in patients with LBBB using invasive quantitative coronary angiography (QCA) (stenosis >= 70%) as reference; to investigate the advantage of adding CTP to coronary computed tomography angiography (CTA) and compare the results with those of single photon emission computed tomography (SPECT) myocardial perfusion scintigraphy. Methods: Thirty patients with LBBB who had undergone SPECT for the investigation of coronary artery disease were referred for stress tomography. Independent examiners performed per-patient and per-coronary territory assessments. All patients gave written informed consent to participate in the study that was approved by the institution's ethics committee. Results: The patients' mean age was 62 +/- 10 years. The mean dose of radiation for the tomography protocol was 9.3 +/- 4.6 mSv. With regard to CTP, the per-patient values for sensitivity, specificity, positive and negative predictive values, and accuracy were 86%, 81%, 80%, 87%, and 83%, respectively (p = 0.001). The per-territory values were 63%, 86%, 65%, 84%, and 79%, respectively (p < 0.001). In both analyses, the addition of CTP to CTA achieved higher diagnostic accuracy for detecting myocardial ischemia than SPECT (p < 0.001). Conclusion: The use of the stress tomography protocol is feasible and has good diagnostic accuracy for assessing myocardial ischemia in patients with LBBB.
bookPart Ressonância magnética cardíaca(2015) NAKAMURA, Debora Yuri Moura; ASSUNçãO JR., Antonildes Nascimento; ROCHITTE, Carlos Eduardo- Rare Association: Chagas' Disease and Hypertrophic Cardiomyopathy(2015) PASTORE, Carlos Alberto; SAMESIMA, Nelson; PEREIRA FILHO, Horacio Gomes; VARONI, Leonardo Paschoal Camacho; ROCHITTE, Carlos Eduardo; VIEIRA, Marcelo Luiz Campos; AVILA, Luiz Francisco Rodrigues de; MELO, Rodrigo de Jesus Louzeiro; PEREIRA, Alexandre da Costa; DAHEER, Julia; CARLO, Carlos Henrique delA woman (49 years) with Chagas' disease showed: ECG, right bundle-branch block and left anterior-superior fascicular block; V-1 has unusual R > R', and elevated ST segment from V-2 to V-6. Additional imaging revealed concomitant HCM and Chagas, which is uncommon. Overlapping of ECG findings can be explained by this rare association of diseases.
- Combined coronary angiography and myocardial perfusion by computed tomography in the identification of flow-limiting stenosis - The CORE320 study: An integrated analysis of CT coronary angiography and myocardial perfusion(2015) MAGALHAES, Tiago A.; KISHI, Satoru; GEORGE, Richard T.; ARBAB-ZADEH, Armin; VAVERE, Andrea L.; COX, Christopher; MATHESON, Matthew B.; MILLER, Julie M.; BRINKER, Jeffrey; CARLI, Marcelo Di; RYBICKI, Frank J.; ROCHITTE, Carlos E.; CLOUSE, Melvin E.; LIMA, Joao A. C.Background: The combination of coronary CT angiography (CTA) and myocardial CT perfusion (CTP) is gaining increasing acceptance, but a standardized approach to be implemented in the clinical setting is necessary. Objectives: To investigate the accuracy of a combined coronary CTA and myocardial CTP comprehensive protocol compared to coronary CTA alone, using a combination of invasive coronary angiography and single photon emission CT as reference. Methods: Three hundred eighty-one patients included in the CORE320 trial were analyzed in this study. Flow-limiting stenosis was defined as the presence of >= 50% stenosis by invasive coronary angiography with a related perfusion defect by single photon emission CT. The combined CTA + CTP definition of disease was the presence of a >= 50% stenosis with a related perfusion defect. All data sets were analyzed by 2 experienced readers, aligning anatomic findings by CTA with perfusion defects by CTP. Results: Mean patient age was 62 +/- 6 years (66% male), 27% with prior history of myocardial infarction. In a per-patient analysis, sensitivity for CTA alone was 93%, specificity was 54%, positive predictive value was 55%, negative predictive value was 93%, and overall accuracy was 69%. After combining CTA and CTP, sensitivity was 78%, specificity was 73%, negative predictive value was 64%, positive predictive value was 0.85%, and overall accuracy was 75%. In a per-vessel analysis, overall accuracy of CTA alone was 73% compared to 79% for the combination of CTA and CTP (P < .0001 for difference). Conclusions: Combining coronary CTA and myocardial CTP findings through a comprehensive protocol is feasible. Although sensitivity is lower, specificity and overall accuracy are higher than assessment by coronary CTA when compared against a reference standard of stenosis with an associated perfusion defect.
- Pulmonary function and use of health care resources after coronary tomography(2015) FERNANDES, Frederico L. A.; FRANCIELLE, Moreira; PESSI, Janaina Danieli; ROCHITE, Carlos Eduardo; CARVALHO-PINTO, Regina Maria; STELMACH, Rafael; CUKIER, Alberto
conferenceObject Association between epicardial fat and subclinical atherosclerosis assessed by coronary computed tomographic angiography in familial hypercholesterolaemia(2015) MANGILI, L. C.; MINAME, M. H.; LIMA, L. M.; ROCHITTE, C. E.; PRADO, R.; KALIL, R.; SANTOS, R. D.conferenceObject Prognostic Value of Combined CT Angiography and Myocardial Perfusion Imaging vs. Invasive Coronary Angiography and Nuclear Stress Perfusion Imaging for Predicting Major Adverse Cardiovascular Events - The CORE320 Multicenter Study(2015) CHEN, Marcus Y.; ROCHITTE, Carlos E.; ARBAB-ZADEH, Armin; DEWEY, Marc; GEORGE, Richard T.; MILLER, Julie M.; NIINUMA, Hiroyuki; YOSHIOKA, Kunihiro; KITAGAWA, Kakuya; NAKAMORI, Shiro; LAHAM, Roger; VAVERE, Andrea L.; CERCI, Rodrigo J.; MEHRA, Vishal C.; NOMURA, Cesar; KOFOED, Klaus F.; JINZAKI, Masahiro; KURIBAYASHI, Sachio; ROOS, Albert de; LAULE, Michael; TAN, Swee Yaw; HOE, John; PAUL, Narinder; RYBICKI, Frank J.; BRINKER, Jeffery A.; ARAI, Andrew E.; COX, Christopher; CLOUSE, Melvin E.; CARLI, Marcelo F. Di; LIMA, Joao A.- T1 Mapping Technique and Applications(2015) FERNANDES, Juliano Lara; ROCHITTE, Carlos EduardoT1 mapping, one form of tissue characterization performed with a parametric approach, has been gaining rapid popularity, as different sequences have been developed to integrate image acquisition into a clinical routine. This technique allows fast progression from the basics of sequence development to its application in normal individuals and distinct diseases, sometimes overriding the more gradual steps taken with other cardiovascular magnetic resonance advances. In this review, the state-of-the-art in T1 mapping is examined, focusing on its techniques, sequences, comparison of native versus extracellular volume fraction measurements, and the current and future clinical applications of the method.
bookPart Ressonância magnética cardíaca(2015) NAKAMURA, Debora Yuri Moura; ASSUNçãO JR., Antonildes Nascimento; ROCHITTE, Carlos Eduardo- Optimized Three-Dimensional Sodium Imaging of the Human Heart on a Clinical 3T Scanner(2015) GAI, Neville D.; ROCHITTE, Carlos; NACIF, Marcelo S.; BLUEMKE, David A.PurposeOptimization of sequence and sequence parameters to allow three-dimensional (3D) sodium imaging of the entire human heart in vivo in a clinically reasonable time. Theory and MethodsA stack of spirals pulse sequence was optimized for cardiac imaging by considering factors such as spoiling, nutation angles, repetition time, echo time, T1/T2 relaxation, off-resonance, data acquisition window, motion, and segmented k-space acquisition. Simulations based on Bloch equations as well as the exact trajectory used for data acquisition provided the basis for choice of parameter combinations for sodium imaging. Sodium phantom scanning was used to validate the choice of parameters and for corroboration with simulations. In vivo cardiac imaging in six volunteers was also performed with an optimized sequence. ResultsPhantom studies showed good correlation with simulation results. Images obtained from human volunteers showed that the heart can be imaged with a nominal resolution of 5 x 5 x 10 mm(3) and with a signal-to-noise ratio >15 (in the septum) in about 6-10 minutes. Long axis views of the reformatted human heart show true 3D imaging capability. ConclusionOptimization of the sequence and its parameters allowed in vivo 3D sodium imaging of the entire human heart in a clinically reasonable time. Magn Reson Med 73:623-632, 2015. (c) 2014 Wiley Periodicals, Inc.