IRIMAR DE PAULA POSSO

(Fonte: Lattes)
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Departamento de Cirurgia, Faculdade de Medicina - Docente
LIM/08 - Laboratório de Anestesiologia, Hospital das Clínicas, Faculdade de Medicina

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Revista / Livro: British Journal of Anaesthesia ×

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    Influence of ageing and male gonads in pain perception in rats
    (2012) ASHMAWI, Hazem; POSSO, Irimar; BULLARA, Carolina; PALMEIRA, Claudia
    Introduction: Pain is complex experience influenced by many factors. Among these factors, there are ageing process and gonadal hormones. The use of animal pain models allows the isolation of variables, facilitating the comprehension of the roles each factor has on pain. Objectives: Two experimental pain models were used, pain induced by formalin paw injection and plantar incision, to study the influence of ageing and male gonads on pain perception. Methods: Adult rats (6 months), aged rats (22 months), young non orchiectomized and orchiectomized rats were evaluated for the number of flinches after paw formalin injection and mechanical withdrawal threshold after plantar incision. Results: The results showed aged rats presented decreased number of flinches than adult rats during phase II of formalin induced behavior at 25, 30 and 35 minutes time points. Aged rats presented lower paw withdrawal threshold after mechanical stimulus in the plantar incision model, at 2nd, 3rd, 4th, 7th and 10th postoperative days, the return to baseline levels occurred after the 18th day in aged rats and after the 10th day in adult rats. Orchiectomized rats presented decreased number of flinches compared to non orchiectomized rats in the initial section of phase I, 5 minutes time point, and in phase II, at 25, 30, 35, 40, 45, 50, 55 and 60 minutes time points. In orchiectomized rats, paw withdrawal threshold was lower when compared to non orchiectomized rats on the 1st, 2nd, 4th and 7th postoperative days. Return to baseline values occurred after the 18th day in orchiectomized rats and after the 14th day in non orchiectomized rats. Conclusions: Data showed that pain perception changes with the ageing process according to the type of stimulus and that male gonads present analgesic effect on both pain models evaluated.