ALEXANDRE ANDRADE LOCH
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/27 - Laboratório de Neurociências, Hospital das Clínicas, Faculdade de Medicina
LIM/27 - Laboratório de Neurociências, Hospital das Clínicas, Faculdade de Medicina
5 resultados
Resultados de Busca
Agora exibindo 1 - 5 de 5
- Disclosing the diagnosis of schizophrenia: A pilot study of the 'Coming Out Proud' intervention (vol 65, pg 244, 2014)(2020) SETTI, V. P. C.; LOCH, A. A.; MODELLI, A.; ROCCA, de Almeida C. C.; HUNGERBUEHLER, I; BILT, M. T. van de; GATTAZ, W. F.; ROSSLER, W.
- Patterns of stigma toward schizophrenia among the general population: A latent profile analysis(2014) LOCH, Alexandre A.; WANG, Yuan-Pang; GUARNIERO, Francisco B.; LAWSON, Fabio L.; HENGARTNER, Michael P.; ROSSSLER, Wulf; GATTAZ, Wagner F.Objective: Our purpose was to assess stigma toward schizophrenia in a representative sample of the Brazilian general population. Methods: The sample consisted of 1015 individuals interviewed by telephone. A vignette describing someone with schizophrenia was read, and four stigma aspects regarding this hypothetical individual were assessed: stereotypes, restrictions, perceived prejudice and social distance. Latent profile analysis searched for stigma profiles among the sample. Multinomial logistic regression was used to find correlates of each class. Results: Four stigma profiles were found; 'no stigma' individuals (n = 251) mostly displayed positive opinions. 'Labelers' (n = 222) scored high on social distance; they more often had familial contact with mental illness and more often labeled the vignette's disorder as schizophrenia. 'Discriminators', the group with the majority of individuals (n = 302), showed high levels of stigmatizing beliefs in all dimensions; discriminators were significantly older. 'Unobtrusive stigma' individuals (n = 240) seemed to demonstrate uncertainty or low commitment since they mostly answered items with the middle/impartial option. Conclusion: Some findings from the international literature were replicated; however, familial contact increased stigma, possibly denoting a locally modulated determinant. Hereby, our study also adds important cross-cultural data by showing that stigma toward schizophrenia is high in a Latin-American setting. We highlight the importance of analyzing the general population as a heterogeneous group, aiming to better elaborate anti-stigma campaigns.
- Childhood maltreatment in individuals at risk of psychosis: Results from the Brazilian SSAPP cohort(2020) FREITAS, Elder Lanzani; LOCH, Alexandre Andrade; CHIANCA, Camille; ANDRADE, Julio Cesar; SERPA, Mauricio Henriques; ALVES, Tania Maria; HORTENCIO, Lucas; PINTO, Marcel Tavares Camilo; BILT, Martinus Theodorus van de; GATTAZ, Wagner Farid; ROESSLER, WulfBackground: Childhood maltreatment is a known risk factor for the development of mental disorders, such as psychotic symptoms. An extensive body of literature about childhood maltreatment and mental health has been developed in wealthy countries, but information about this connection is lacking in developing countries. Aims: To explore a possible relationship between childhood maltreatment and ultra-high risk of psychosis in a non-help-seeking population in a low- and middle-income country. Methods: A household survey was conducted in Sao Paulo, Brazil, involving over 2,500 individuals aged 18-30 years who were randomly selected from the general population. The participants underwent screening with the Prodromal Questionnaire. Ultra-high risk status was assessed using the Structured Interview for Prodromal Syndromes, and childhood maltreatment was assessed using the Childhood Trauma Questionnaire. The final sample comprised 87 ultra-high risk individuals and 115 controls. Results: Childhood maltreatment was significantly more present among ultra-high risk individuals. In ultra-high risk individuals, physical and emotional neglect were inversely related to grandiosity symptoms, physical abuse was related to perceptual abnormalities and physical neglect was related to disorganized speech and thought. Conclusion: This is the first study to investigate the relationship between childhood maltreatment and ultra-high risk status and psychopathological features in a large Latin American sample. Further studies in this field are necessary to better understand the specific influence of various early life adversities on psychosis risk.
- Disclosing the diagnosis of schizophrenia: A pilot study of the 'Coming Out Proud' intervention(2019) SETTI, Viviane Piagentini Candal; LOCH, Alexandre Andrade; MODELLI, Arlete; ROCCA, Cristiana Castanho de Almeida; HUNGERBUEHLER, Ines; BILT, Martinus Theodorus van de; GATTAZ, Wagner Farid; ROESSLER, WulfBackground: Schizophrenia is one of the most stigmatized psychiatric disorders, and disclosing it is often a source of stress to individuals with the disorder. The Coming Out Proud (COP) group intervention is designed to reduce the stigma's negative impact and help participants decide if they want to disclose their disorder. Aims: To assess the effect of the COP intervention in individuals with the diagnosis of schizophrenia. Methods: A pilot study of 3 2-hour group lessons (6-12 participants) per week. Individuals were selected from three specialized outpatient services in Sao Paulo, Brazil; 46 people were willing to participate, 11 dropped out during the intervention and 4 were excluded due to low intelligence quotient (IQ), resulting in a final sample of 31 participants. Outcomes were assessed before (T0/baseline) and after (T1/directly) after the COP intervention, and at 3-week follow-up (T2/3 weeks after T1). We applied eight scales, of which four scales are analyzed in this article (Coming Out with Mental Illness Scale (COMIS), Cognitive Appraisal of Stigma as a Stressor (CogApp), Self-Stigma of Mental Illness Scale-Short Form (SSMIS) and Perceived Devaluation-Discrimination Questionnaire (PDDQ)). Results: People who completed the COP intervention showed a significant increase in the decision to disclose their diagnosis (22.5% in T0 vs 67.7% in T2). As to the perception of stigma as a stressor, mean values significantly increased after the intervention (T0 = 3.83, standard deviation (SD) = .92 vs T2 = 4.44, SD = 1.05; p = .006). Two results had marginal significance: self-stigma was reduced (T0 = 3.10, SD = 1.70 vs T2 = 2.73, SD = 1.87; p = .063), while perceived discrimination increased (T0 = 2.68, SD = .55 vs T2 = 2.93, SD = .75; p = .063). Conclusion: This study suggests that the COP group intervention facilitated participants' disclosure decisions, and the increasing awareness of stigma as a stressor in life may have facilitated their decision to eventually disclose their disorder. The results raise questions that require further analysis, taking sociocultural factors into account, as stigma is experienced differently across cultures.
- Suicide literacy mediates the path from religiosity to suicide stigma among Muslim community adults: Cross-sectional data from four Arab countries(2023) FEKIH-ROMDHANE, Feten; DAHER-NASHIF, Suhad; STAMBOULI, Manel; ALHUWAILAH, Amthal; HELMY, Mai; SHUWIEKH, Hanaa Ahmed Mohamed; LEMINE, Cheikh Mohamed Fadel Mohamed; RADWAN, Eqbal; SAQUIB, Juliann; SAQUIB, Nazmus; FAWAZ, Mirna; ZARROUQ, Btissame; NASER, Abdallah Y.; OBEID, Sahar; SALEH, Maan; HAIDER, Sanad; MILOUD, Lahmer; BADRASAWI, Manal; HAMDAN-MANSOUR, Ayman; BARBATO, Mariapaola; BAKHIET, Aisha; SAYEM, Najat; ADAWI, Samir; GREIN, Fatheya; LOCH, Alexandre Andrade; CHEOUR, Majda; HALLIT, SouheilBackground:The majority of research attention has been devoted to the link between religiosity and suicide risk, and a considerable amount of studies has been carried out on how stigma impacts individuals with mental health problems of different kinds. However, the interplay between religiosity, suicide literacy and suicide stigma has seldom been empirically researched, especially quantitatively. We sought through this study to redress the imbalance of research attention by examining the relationship between religiosity and suicide stigma; and the indirect and moderating effects of suicide literacy on this relationship. Method: A cross-sectional web-based survey was conducted among Arab-Muslim adults originating from four Arab countries (Egypt: N=1029, Kuwait: N=2182, Lebanon N=781, Tunisia N=2343; Total sample: N=6335). The outcome measures included the Arabic Religiosity Scale which taps into variation in the degree of religiosity, the Stigma of Suicide Scale-short form to the solicit degree of stigma related to suicide, and the Literacy of Suicide Scale explores knowledge and understanding of suicide. Results: Our Mediation analyses findings showed that literacy of suicide partially mediated the association between religiosity and stigmatizing attitude toward suicide. Higher religiosity was significantly associated with less literacy of suicide; higher literacy of suicide was significantly associated with less stigma of suicide. Finally, higher religiosity was directly and significantly associated with more stigmatization attitude toward suicide. Conclusion: We contribute the literature by showing, for the first time, that suicide literacy plays a mediating role in the association between religiosity and suicide stigma in a sample of Arab-Muslim community adults. This preliminarily suggests that the effects of religiosity on suicide stigma can be modifiable through improving suicide literacy. This implies that interventions targeting highly religious individuals should pay dual attention to increasing suicide literacy and lowering suicide stigma.