THIAGO BITAR MORAES BARROS
Índice h a partir de 2011
4
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
2 resultados
Resultados de Busca
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- Adult dermatomyositis: experience of a Brazilian tertiary care center(2012) SOUZA, Fernando Henrique Carlos de; BARROS, Thiago Bitar Moraes; LEVY-NETO, Mauricio; SHINJO, Samuel KatsuyukiObjective: To report the results of a retrospective cohort involving 139 patients with dermatomyositis, conducted from 1991 to 2011. Methods: All patients met at least four of the five Bohan and Peter criteria (1975). Results: The patients' mean age at disease onset was 41.7 +/- 14.1 years, and mean disease duration was 7.2 +/- 5.2 years. The sample comprised 90.2% white patients and 79.9% female patients. Constitutional symptoms occurred in less than half of the patients. Cutaneous and joint involvements occurred in 95.7% and 41.7% of the patients, respectively. Incipient pneumopathy, ground glass opacities and/or pulmonary fibrosis were present in 48.2% of the patients. All patients received prednisone (1 mg/kg/day) and 51.1% also received intravenous methylprednisolone (1 g/day for three days). Several immunosuppressants were used as corticosteroid sparing agents according to tolerance, side effects and/or refractoriness. Although disease relapse (clinical and/or laboratory) occurred in 53.2% of the patients, 76.3% were in disease remission at the end of the study. The rate of severe infection was 35.3%, and herpes zoster predominated. There were 15(10.8%) cases of cancer, 12 within one year after the diagnosis. There were 16 deaths (11.5%), and their major causes were sepsis/septic shock (27.5%), pneumopathy attributed to the disease (31.3%), neoplasms (31.3%), and cardiovascular events (12.5%). Conclusions: In this study, the clinical and laboratory data were similar to those of other population groups described in the literature, with minimal differences regarding the frequency and characteristics of the extramuscular manifestations.
- Prevalence of Psoriatic Arthritis in a Large Cohort of Brazilian Patients with Psoriasis(2015) RANZA, Roberto; CARNEIRO, Sueli; QURESHI, Abrar A.; MARTINS, Gladys; RODRIGUES, Jose Joaquim; ROMITI, Ricardo; BARROS, Thiago Bitar M.; CARNEIRO, Jamille; SAMPAIO, Ana Luisa; GRYNSZPAN, Rachel; MARKUS, Juliana; PINTO, Rogerio Melo Costa; GOLDENSTEIN-SCHAINBERG, ClaudiaObjective. To determine the prevalence of psoriatic arthritis (PsA) in a large cohort of Brazilian patients with psoriasis (PsO) being seen at dermatology centers. Methods. A multicenter study was conducted in 4 university dermatology clinics. In each center, consecutive patients with confirmed diagnoses of PsO were evaluated by a rheumatologist. Individuals were classified as having PsA according to the ClASsification criteria for Psoriatic ARthritis (CASPAR). Laboratory tests and radiographs were performed, as needed, based on the clinical judgment of the rheumatologist. Results. A total of 524 patients with PsO were evaluated. The mean age was 48.5 +/- 14.5 years, 50% were women, and the mean PsO duration was 15.4 +/- 11.7 years. A diagnosis of PsA was documented in 175 patients (33%), of whom 49% were newly identified by the rheumatologist. Most individuals with PsA (72%) had peripheral involvement, 11% had isolated axial involvement, and 17% had both peripheral and axial involvement. Dactylitis occurred in 20% and clinical enthesitis in 30% of the patients. Laboratory and/or radiograph tests were necessary for a definitive diagnosis of PsA in 42 of 175 individuals (24%). Conclusion. In our study, one-third of Brazilian patients with PsO, followed in dermatology settings, were diagnosed with PsA by a rheumatologist. Almost half of subjects with PsA had no previous diagnosis. A collaboration between dermatologists and rheumatologists is greatly needed to establish earlier PsA diagnoses and adequate multidisciplinary management.