MARCELO VIVOLO AUN
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina
8 resultados
Resultados de Busca
Agora exibindo 1 - 8 de 8
- Drug-induced anaphylaxis: is it an epidemic?(2018) GIAVINA-BIANCHI, Pedro; AUN, Marcelo V.; KALIL, JorgePurpose of reviewThe present review addresses the epidemiology, analyzes the current data and promotes global awareness of drug-induced anaphylaxis.Recent findingsAnaphylaxis is a medical emergency that may cause death! In the last decade, studies have shown an increasing incidence and prevalence of anaphylaxis.SummaryDrug-induced anaphylaxis fatalities have increased, and this syndrome remains underdiagnosed and undertreated.
- Brazilian Guidelines for Hereditary Angioedema Management-2017 Update Part 1: Definition, Classification and Diagnosis(2018) GIAVINA-BIANCHI, Pedro; ARRUDA, Luisa Karla; AUN, Marcelo V.; CAMPOS, Regis A.; CHONG-NETO, Herberto J.; CONSTANTINO-SILVA, Rosemeire N.; FERNANDES, Fatima R.; FERRARO, Maria F.; FERRIANI, Mariana P. L.; FRANCA, Alfeu T.; FUSARO, Gustavo; GARCIA, Juliana F. B.; KOMNINAKIS, Shirley; MAIA, Luana S. M.; MANSOUR, Eli; MORENO, Adriana S.; MOTTA, Antonio A.; PESQUERO, Joao B.; PORTILHO, Nathalia; ROSARIO, Nelson A.; SERPA, Faradiba S.; SOLE, Dirceu; TAKEJIMA, Priscila; TOLEDO, Eliana; VALLE, Solange O. R.; VERONEZ, Camila L.; GRUMACH, Anete S.Hereditary angioedema is an autosomal dominant disease characterized by recurrent angioedema attacks with the involvement of multiple organs. The disease is unknown to many health professionals and is therefore underdiagnosed. Patients who are not adequately diagnosed and treated have an estimated mortality rate ranging from 25% to 40% due to asphyxiation by laryngeal angioedema. Intestinal angioedema is another important and incapacitating presentation that may be the main or only manifestation during an attack. In this article, a group of experts from the ""Associacao Brasileira de Alergia e Imunologia (ASBAI)'' and the ""Grupo de Estudos Brasileiro em Angioedema Hereditario (GEBRAEH)'' has updated the Brazilian guidelines for the diagnosis and treatment of hereditary angioedema.
- Angioedema associated with nonsteroidal anti-inflammatory drugs(2016) GIAVINA-BIANCHI, Pedro; AUN, Marcelo Vivolo; JARES, Edgardo Jose; KALIL, JorgePurpose of review The review critically assesses the different phenotypes of angioedemas associated with NSAIDs. Angioedemas exacerbated or induced by NSAIDs have high morbidity and, when they affect the larynx, can lead to death by asphyxiation. Recent findings Angioedema can present as a manifestation of a syndrome such as anaphylaxis or it can be a separate entity, which comprises different forms that can be diagnosed based on specific criteria. NSAIDs are the drugs most used worldwide and they are also one of the leading causes of angioedema. Summary The manuscript addresses the pathophysiology and pharmacogenetics of angioedema, reviews its classification and assesses the diagnosis and management of angioedemas exacerbated and induced by NSAIDs.
- United airway disease: current perspectives(2016) GIAVINA-BIANCHI, Pedro; AUN, Marcelo Vivolo; TAKEJIMA, Priscila; KALIL, Jorge; AGONDI, Rosana CamaraUpper and lower airways are considered a unified morphological and functional unit, and the connection existing between them has been observed for many years, both in health and in disease. There is strong epidemiologic, pathophysiologic, and clinical evidence supporting an integrated view of rhinitis and asthma: united airway disease in the present review. The term ""united airway disease"" is opportune, because rhinitis and asthma are chronic inflammatory diseases of the upper and lower airways, which can be induced by allergic or nonallergic reproducible mechanisms, and present several phenotypes. Management of rhinitis and asthma must be jointly carried out, leading to better control of both diseases, and the lessons of the Allergic Rhinitis and Its Impact on Asthma initiative cannot be forgotten.
- Animal models of asthma: utility and limitations(2017) AUN, Marcelo Vivolo; BONAMICHI-SANTOS, Rafael; ARANTES-COSTA, Fernanda Magalhaes; KALIL, Jorge; GIAVINA-BIANCHI, PedroClinical studies in asthma are not able to clear up all aspects of disease pathophysiology. Animal models have been developed to better understand these mechanisms and to evaluate both safety and efficacy of therapies before starting clinical trials. Several species of animals have been used in experimental models of asthma, such as Drosophila, rats, guinea pigs, cats, dogs, pigs, primates and equines. However, the most common species studied in the last two decades is mice, particularly BALB/c. Animal models of asthma try to mimic the pathophysiology of human disease. They classically include two phases: sensitization and challenge. Sensitization is traditionally performed by intraperitoneal and subcutaneous routes, but intranasal instillation of allergens has been increasingly used because human asthma is induced by inhalation of allergens. Challenges with allergens are performed through aerosol, intranasal or intratracheal instillation. However, few studies have compared different routes of sensitization and challenge. The causative allergen is another important issue in developing a good animal model. Despite being more traditional and leading to intense inflammation, ovalbumin has been replaced by aeroallergens, such as house dust mites, to use the allergens that cause human disease. Finally, researchers should define outcomes to be evaluated, such as serum-specific antibodies, airway hyperresponsiveness, inflammation and remodeling. The present review analyzes the animal models of asthma, assessing differences between species, allergens and routes of allergen administration.
- Update on perioperative hypersensitivity reactions: joint document from the Brazilian Society of Anesthesiology (SBA) and Brazilian Association of Allergy and Immunology (ASBAI) - Part II: etiology and diagnosis(2020) SOLE, Dirceu; SPINDOLA, Maria Anita Costa; AUN, Marcelo Vivolo; AZI, Liana Maria Torres de Araujo; BERND, Luiz Antonio Guerra; GARCIA, Daniela Bianchi; CAPELO, Albertina Varandas; CUMINO, Debora de Oliveira; LACERDA, Alex Eustaquio; LIMA, Luciana Cavalcanti; MORATO, Edelton Flavio; NUNES, Rogean Rodrigues; RUBINI, Norma de Paula Motta; SILVA, Jane da; TARDELLI, Maria Angela; WATANABE, Alexandra Sayuri; CURI, Erick Freitas; SANO, FlavioThis second joint document, written by experts from the Brazilian Association of Allergy and Immunology (ASBAI) and Brazilian Society of Anesthesiology (SBA) concerned with perioperative anaphylaxis, aims to review the pathophysiological reaction mechanisms, triggering agents (in adults and children), and the approach for diagnosis during and after an episode of anaphylaxis. As anaphylaxis assessment is extensive, the identification of medications, antiseptics and other substances used at each setting, the comprehensive data documentation, and the use of standardized nomenclature are key points for obtaining more consistent epidemiological information on perioperative anaphylaxis. (C) 2020 Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Anestesiologia.
- Adults and children with anaphylaxis in the emergency room: why it is not recognized?(2018) AUN, Marcelo V.; KALIL, Jorge; GIAVINA-BIANCHI, PedroPurpose of review Despite many international guidelines have been published in the last 10 years, anaphylaxis continues to be underdiagnosed, undernotified, and undertreated. Anaphylactic reactions in adults and children in emergency departments are frequently not recognized, leading to underutilization of epinephrine, and a higher risk of death. Recent findings A few studies have been recently published showing that educational intervention for both physicians and other healthcare professionals improve diagnosis and treatment of anaphylaxis. Moreover, the new International Classification of Diseases, 11th edition improved classification of anaphylaxis, making it easier to be notified. Summary Anaphylaxis is a life-threatening hypersensitivity reaction that is most frequently seen by emergency physicians and nurses than allergists or immunologists. Education seems to be best strategy to improve management of this severe condition.
- Microbiome and Asthma: What Have Experimental Models Already Taught Us?(2015) BONAMICHI-SANTOS, R.; AUN, M. V.; AGONDI, R. C.; KALIL, J.; GIAVINA-BIANCHI, P.Asthma is a chronic inflammatory disease that imposes a substantial burden on patients, their families, and the community. Although many aspects of the pathogenesis of classical allergic asthma are well known by the scientific community, other points are not yet understood. Experimental asthma models, particularly murine models, have been used for over 100 years in order to better understand the immunopathology of asthma. It has been shown that human microbiome is an important component in the development of the immune system. Furthermore, the occurrence of many inflammatory diseases is influenced by the presence of microbes. Again, experimental models of asthma have helped researchers to understand the relationship between the microbiome and respiratory inflammation. In this review, we discuss the evolution of murine models of asthma and approach the major studies involving the microbiome and asthma.