MARCELO VIVOLO AUN
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
- Is age associated with the development of antibodies against botulinum toxin?(2013) AUN, M. V.; CHUNG, T. M.; SANTOS, K. S.; BATTISTELLA, L. M. R.; RIZZO, L. V.; KALIL, J.; GIAVINA-BIANCHI, P.
conferenceObject Characterization of Asthmatic Patients with Vocal Cord Dysfunction(2013) AGONDI, Rosana C.; GALVAO, Violeta; AUN, Marcelo; BISACCIONI, Carla; KALIL, Jorge; GIAVINA-BIANCHI, PedroRATIONALE: The vocal cord dysfunction (VCD) is a syndrome characterized by paradoxical movement of the vocal folds that causes respiratory distress. Our goal is to analyze asthmatic patients with VCD. METHODS: This was an observational and cross-sectional study involving patients over 18 years of age who had been diagnosed with asthma according to the Global Initiative for Asthma guidelines. Eighty-five patients were analyzed. They were submitted to spirometry, and tested for total and specific IgE to aeroallergens (skin prick test and/or in vitro ). RESULTS: The mean age was 52.1 years, and 93% were female. Sixty- seven patients had moderate or severe persistent asthma. Spirometry was normal or showed mild obstructive respiratory disease in 81% of them. Spirometric alterations suggestive of VCD were observed in 24% of the patients. The mean serum total IgE was 303 IU/mL and the detection of specific IgE was present in 76% of them. Gastroesophageal reflux disease was observed in 65% of the patients. When classified according to gender, we found that men were younger, had higher total IgE and higher prevalence of specific IgE. CONCLUSIONS: There was a higher prevalence of the association asthma and VCD in women, suggesting that this association could be masked in men. However, we observed that the clinical characteristics were different between men and women. We found a high prevalence of atopy that could be another confounding factor. There was a weak association between asthma and spirometric severity classifications, suggesting a potential role for VCD in making difficult to the asthma control in some patients.conferenceObject Sensitisation by subcutaneous route is superior to intraperitoneal route in the induction of asthma by house dust mite in a murine model(2013) V, M. Aun; SARAIVA-ROMANHOLO, B. M.; ARANTES-COSTA, F. M.; ALMEIDA, F. M.; MARTINS, M. A.; KALIL, J.; GIAVINA-BIANCHI, P.conferenceObject Incidence of Intraoperative Anaphylaxis in A University General Hospital in Brazil(2013) GARRO, Laila Sabino; CARMONA, Maria Jose Carvalho; SOARES, Iracy Silvia Correa; AUN, Marcelo Vivolo; RIBEIRO, Marisa Rosimeire; RODRIGUES, Adriana Teixeira; KALIL, Jorge; GIAVINA-BIANCHI, Pedro; MOTTA, Antonio AbilioRATIONALE: The epidemiology of intraoperative anaphylaxis is un-known in Brazil. We aimed to evaluate the incidence and clinical features of anaphylaxis during anesthesia in a University General Hospital in Sao Paulo, Brazil. METHODS: A cross-sectional, observational study analyzing data fromvoluntary notification sent by anesthesiologists, about occurrence of intraoperative anaphylaxis during the period between January and December 2010. The diagnostic criteria for anaphylaxis were based onthe World Allergy Organization Guidelines. We analyzed the incidence of intraoperative anaphylaxis, clinical features, severity of anaphylaxis, types of surgical procedures, classification of anesthetic risk (American Society of Anesthesiologists - ASA), culprit agent cited by the anesthesiologist and type of treatment provided. RESULTS: The incidence of intraoperative anaphylaxis was 69:10.000 surgeries. The mean age of patients with anaphylaxis was 36.7 years-old and 57% were women. The most common procedures associated with anaphylaxis were the abdominal non-vascular (17.1%) and urologic (17.1%) surgeries. Skin symptoms were the most prevalent (85.7%) and all patients who presented cardiovascular shock were classified as ASA II (42.9%) or ASA III (57.1%). Epinephrine was used preferentially in anaphylaxis grade 3 (72.7%), while a few patients with anaphylaxis grades 1 and 2 took the drug (2.1% and 16.7, respectively). The most commonly etiologic drugs cited by the anesthesiologists were the neuromuscular blocking agents (22.9%). CONCLUSIONS: Our incidence of intraoperative anaphylaxis was higher than in other studies reported in the literature. These data are a warning signal to encourage measures to reduce the incidence of these severe reactions.- Rhinoconjunctivitis elicited by skin prick test (vol 38, pg 345, 2010)(2013) GIAVINA-BIANCHI, P.; BISACCIONI, C.; AUN, M. Vivolo; CAJUELA, E.; AGONDI, R. C.; KALIL, J.
conferenceObject Acetaminophen Hypersensitivity: Myth or Reality(2013) BITTAR, Renata P.; AUN, Marcelo; GARRO, Laila Sabino; RIBEIRO, Marisa Rosimeire; KALIL, Jorge; GIAVINA-BIANCHI, Pedro; MOTTA, Antonio AbilioRationale: Acetaminophen is considered safe for patients with hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs). However, some patients also report reaction to paracetamol. We evaluated outcomes and safety of drug provocation tests (DPT) with paracetamol in patients who reported adverse reactions both to NSAIDs and acetaminophen. Methods: Retrospective observational study by analyzing the results of DPT with acetaminophen 500mg per dose, performed from January 2005 to July 2012. We evaluated patients who reported acute reactions (less than 24 hours after taking the medication) due to NSAIDs. Only patients who presented urticaria, angioedema or anaphylaxis after taking two or more NSAIDs from different groups were included. All of them reported the same symptoms after taking paracetamol. Results: We evaluated 86 patients submitted to DPT with acetaminophen. The mean age was 36.7 years and 73.2% were female. We found 7 positive challenges (8.1%), all with immediate symptoms. Six patients presented mild urticaria, one of them associated to eyelid angioedema. One patient had pruritus and mild facial angioedema. All of them were successfully treated with oral antihistamines and corticosteroids and none had to be hospitalized. Conclusions: These data confirm the hypothesis that acetaminophen 500mg is a safe therapeutic option in NSAIDs reactors, even if they report a previous reaction to that drug. We believe some of these patients have doubt about the right drug and dose involved in the reactions. Thus patients who report previous reaction both to NSAIDs and paracetamol, the first acetaminophen dose should be supervised and not exceed 500mg.