MARTINUS THEODORUS VAN DE BILT

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10
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/27 - Laboratório de Neurociências, Hospital das Clínicas, Faculdade de Medicina

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Agora exibindo 1 - 10 de 23
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    Association between Childhood Adversity and Ultra-High Risk for Psychosis Status in a Populational Sample of Sao Paulo, Brazil
    (2017) LOCH, Alexandre; ALVES, Tania Maria; FREITAS, Elder Lanzani; HORTENCIO, Lucas; ANDRADE, Julio Cesar; BILT, Martinus Theodorus van de; FONTONI, Marcos Roberto; SERPA, Mauricio; CHIANCA, Camille; GATTAZ, Wagner Farid; ROESSLER, Wulf
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    Treatment of Negative Symptoms of Schizophrenia With tDCS (Transcranial Direct Current Stimulation): A Randomized, Sham-Controlled, Double-Blinded Clinical Trial
    (2018) VALIENGO, Leandro; BILT, Martinus Theodorus van de; SERPA, Mauricio; GORDON, Pedro; HELKIS, Helio; GATTAZ, Wagner Farid; LACERDA, Acioly; BRUNONI, Andre
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    Anti-psychotic Treatment Decreased iPLA2 Activity in First Episode Drug Naive Patients (DNP)
    (2014) TALIB, Leda Leme; JOAQUIM, Helena P. G.; SERPA, Mauricio H.; BILT, Martinus Th van de; BUSATTO, Geraldo; ZANETTI, Marcus V.; GATTAZ, Wagner F.
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    TREATMENT OF NEGATIVE SYMPTOMS OF SCHIZOPHRENIA WITH TRANSCRANIAL CURRENT STIMULATION (TDCS): RESULTS OF RANDOMIZED, DOUBLE-BLINDED, SHAMCONTROLLED TRIAL
    (2018) VALIENGO, Leandro; GORDON, Pedro; SERPA, Mauricio; LACERDA, Acioly; GATTAZ, Wagner; BILT, Martinus Van de; HELKIS, Helio; BRUNONI, Andre
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    Genetic Polymorphisms Related to Dopamine, Serotonine and BDNF Might be Specific to Particular Symptom Dimensions in Schizophrenia
    (2012) LOCH, Alexandre A.; BIO, Danielle S.; BILT, Martinus T. van de; PRADO, Carolina M.; ZANETTI, Marcus V.; GATTAZ, Wagner F.
    Background: Schizophrenia is held to be result of multiple small-effect genes and their interplay with environment. Several of these genes have been discovered, but their exact role in the disease is unclear. The objective of this study is to assess relationship between genetic polymorphisms and specific symptom dimensions in schizophrenia. Methods: Fifty-three outpatients with schizophrenia from the Institute of Psychiatry, Sao Paulo,Brazil, were selected. Psychopathology was evaluated through SCID-I, PANSS and neuropsychological assessment. Genotyping was performed by real-time PCR allelic discrimination. Polymorphisms HTR2A-T102C,-rs6314 and -rs1928042, HTR2C-rs6318 and -rs3813929, DRD3-rs6280, BDNF-rs6265 and COMT-rs4680 were analyzed. Associations between genetic polymorphisms and psychopathology were measured. Factor analysis was performed between psychopathological measures yielding symptom dimensions. Generalized linear models were conducted between these dimensions and positively related genetic polymorphisms; models were repeated including cofactor “refractoriness”. Results: HTR2C(rs6318) genotype CC(ser/ser) and DRD3 genotype CC(gly/gly) were related to worst cognition(p=0.01-0.03). DRD3 genotype TT(ser/ser) was associated with negative symptoms(p=0.04-0.05). BDNF genotype GA(val/met) and COMT genotype GG(val/val) were associated with positive symptoms(p=0.00-0.04). Factor analysis yielded 7 symptom dimensions: cognition was related to DRD3 and HTR2C-rs6318 (B=1.01,p=0.00;B=-0.92,p=0.04,respectively). Disorganization-catatonia was related to BDNF and HTR2C-rs6318 (B=-0.62,p=0.05;B=1.01,p=0.03,respectively). Paranoid-influence delusions were related to DRD3, HTR2C-rs6318 and HTR2A-rs1928042 (B=-1.03,p=0.00;B=-1.31,p=0.00;B=-1.04,p=0.04,respectively). Other delusions/hallucinations were related to DRD3, HTR2C-rs3813929 and BDNF (B=-1.1,p=0.01;B=-1.00,p=0.03;B=0.80,p=0.01,respectively). Negative symptoms were related to refractoriness (B=1.10,p=0.00). Dimensions hallucinations/bizarre delusion and tactile hallucinations did not correlate with any predictor. Conclusions: Our study proposes that genetic polymorphisms might be specific in determining certain symptom dimensions in schizophrenia, suggesting differential underlying physiopathological mechanisms for them.
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    Clinical Use of Genetic Polymorphisms as Markers of Refractoriness in Schizophrenia
    (2012) BILL, Martinus T. van de; PRADO, Carolina M.; OJOPI, Elida P. B.; LOCH, Alexandre A.; ZANETTI, Marcus V.; SOUSA, Rafael A. T.; MACHADO-VIEIRA, Rodrigo; GATTAZ, Wagner F.
    Background: Pharmacogenetics studies have demonstrated the importance of various neurotransmitter systems in mediating drug effectiveness. Due to the importance of the dopaminergic system in the activity of antipsychotics, proteins that regulate the availability of dopamine may influence the response to drug treatment, as the enzyme catechol-O-methyl-transferase (COMT), which catalyzes the breakdown of dopamine. Some associations have already been described between Val108/158Met polymorphism and response, with individuals carrying the Met allele presenting the best answer. However, most of the findings reported have not been universally replicated. Methods: The study enrolled 89 schizophrenia patients divided in two groups: 59 refractory patients according to IPAP algorithm (International Psychopharmacology Algorithm Project) and 30 non-refractory patients. Polymorphisms in COMT (rs4680), HTR2A (T102C, rs6314, rs1928042), HTR2C (rs6318, rs3813929), CHRNA7(rs7164043), BDNF (rs6265), DRD3 (rs6280) and GRM8 (rs7778604) genes were evaluated by allelic discrimination using the TaqMan® system. Results: regarding the polymorphism rs4680 (Val158Met) of the COMT gene, among the non-refractory patients we found 7% AA, 50% AG and 43% GG genotypes. Among refractory patients we found 20% AA, 59% AG and 21% GG. After the X2 test, we found a difference in the genotype distribution between the two groups (p=0.043). For the other polymorphisms in genes HTR2A, HTR2C, CHRNA7, BDNF, DRD3, and GRM8, no significant difference was found. Conclusions: Our findings do not confirm previous data. In our study there is a higher prevalence of individuals homozygous for Met in the refractory group and a higher prevalence of individuals homozygous for Val the non-refractory (p=0.043).
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    Increased Glycogen Synthase Kinase-3B (GSK3B) Expression in Platelets of First Onset Psychosis Non-affective Patients
    (2014) JOAQUIM, Helena P. G.; TALIB, Leda L.; BILT, Martinus Th van de; ZANETTI, Marcus V.; BUSATTO, Geraldo; SERPA, Mauricio H.; GATTAZ, Wagner F.
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    ANTIPSYCHOTIC TREATMENT DECREASED IPLA2 ACTIVITY IN FIRST EPISODE DRUG NAIVE PATIENTS WITH SCHIZOPHRENIA
    (2014) TALIB, Leda L.; JOAQUIM, Helena; SERPA, Mauricio; BUSATTO, Geraldo; BILT, Martinus van de; ZANETTI, Marcus; GATTAZ, Wagner
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    Neuroanatomical Pattern Classification in Unmedicated First-Episode Psychosis: Influence of Different Imaging Feature Selection
    (2012) SERPA, Mauricio H.; ZANETTI, Marcus V.; VAROL, Erdem; CHAIM, Tiffany M.; GAONKAR, Bilwaj; DOSHI, Jimit; BILT, Martinus T. van de; SALLET, Paulo C.; GATTAZ, Wagner F.; BUSATTO, Geraldo F.; DAVATZIKOS, Christos
    Background: The application of pattern classification approaches is thought to hold promise as an auxiliary tool to aid clinical diagnoses in psychiatric practice. However, few neuroimaging studies to date have investigated the usefulness of these methods in the evaluation of schizophrenia and related psychoses. Moreover, most of patients enrolled in such studies were already receiving antipsychotic medication, an important confounding factor for brain measures. Methods: Eleven treatment-naïve first-episode psychosis (FEP) individuals and 19 controls underwent T1-MPRAGE and 64-direction diffusion tensor imaging (DTI) acquisitions using a 1.5T MRI scanner. Volumetric maps of gray matter, white matter and ventricular compartments were generated through a robust routine of deformation-based morphometry. A new approach adequate for spatial normalization of tensor fields was used to generate fractional anisotropy (FA) and mean diffusivity maps. A multivariate classifier based on support vector machine was employed to identify the best set of morphological and DTI features that discriminate FEP individuals from controls. Diagnostic measures were obtained through ROC curve analyses. Results: The discrimination performance of the classifier varied according to the combination of different features, and the greater area under the curve value (0.68) was obtained when the FA map was employed in isolation. The resulting spatial map revealed a predominant pattern of increased FA in the right parietal region of FEP patients relative to controls, which may reflect differences in functional activity. Conclusions: This preliminary report suggests that FA indices afford the best discrimination between treatment-naïve FEP patients and controls relative to other morphometric and DTI features.
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    PLA2 GENE EXPRESSION IN FIRST EPISODE DRUG NAIVE PATIENTS
    (2014) KERR, Daniel S.; SERPA, Mauricio; TALIB, Leda L.; BILT, Martinus Theodorus Van De; ALCANTARA, Juliana; CHAIM, Tiffany; BUSATTO, Geraldo; ZANETTI, Marcus; GATTAZ, Wagner