JOAO MARCOS SALGE
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
9 resultados
Resultados de Busca
Agora exibindo 1 - 9 de 9
- Effect of weight-loss on the dynamic hyperinflation in obese asthmatics(2015) SILVA, Aline G.; FREITAS, Patricia D.; FERREIRA, Palmira G.; FERNANDES, Frederico L. A.; SALGE, Joao M.; STELMACH, Rafael; CUKIER, Alberto; MARTINS, Milton A.; CARVALHO, Celso R. F.
- Airway resistance and obesity are independent factors for the occurrence of dynamic hyperinflation in asthmatics(2015) FERREIRA, Palmira G.; FREITAS, Patricia D.; SILVA, Aline G.; FERNANDES, Frederico L. A.; SALGE, Joao M.; STELMACH, Rafael; CUKIER, Alberto; CARVALHO-PINTO, Regina; MARTINS, Milton A.; CARVALHO, Celso R. F.
- Characterization of the severity of dyspnea in patients with bronchiectasis: correlation with clinical, functional, and tomographic aspects(2020) NUCCI, Maria Cecilia Nieves Maiorano de; FERNANDES, Frederico Leon Arrabal; SALGE, Joao Marcos; STELMACH, Rafael; CUKIER, Alberto; ATHANAZIO, RodrigoObjective: To characterize a population of patients with bronchiectasis, correlating clinical, radiological, and functional aspects with the severity of dyspnea. Methods: This was a cross-sectional study involving adult patients with HRCT-confirmed bronchiectasis, categorized according to the severity of dyspnea (as being mildly or severely symptomatic, on the basis of the modified Medical Research Council scale). We correlated the severity of dyspnea with clinical parameters, functional parameters (spirometry values, lung volumes, and DLCO), and CT parameters. Results: We evaluated 114 patients, 47 (41%) of whom were men. The median age (interquartile range) was 42 years (30-55 years). The most common form was idiopathic bronchiectasis. Of the 114 patients, 20 (17.5%) were colonized with Pseudomonas aeruginosa and 59 (51.8%) were under continuous treatment with macrolides. When we applied the Exacerbation in the previous year, FEV1, Age, Colonization, Extension, and Dyspnea score, the severity of dyspnea was categorized as moderate in 54 patients (47.4%), whereas it was categorized as mild in 50 (43.9%) when we applied the Bronchiectasis Severity Index. The most common lung function pattern was one of obstruction, seen in 95 patients (83.3%), and air trapping was seen in 77 patients (68.7%). The prevalence of an obstructive pattern on spirometry was higher among the patients with dyspnea that was more severe, and most functional parameters showed reasonable accuracy in discriminating between levels of dyspnea severity. Conclusions: Patients with bronchiectasis and dyspnea that was more severe had greater functional impairment. The measurement of lung volumes complemented the spirometry data. Because bronchiectasis is a complex, heterogeneous condition, a single variable does not seem to be sufficient to provide an overall characterization of the clinical condition.
bookPart Métodos Diagnósticos Funcionais em Doenças Respiratórias(2016) SALGE, João Marcos; FERNANDES, Frederico Leon Arrabal; ALBUQUERQUE, André Luis Pereira debookPart Anatomia e Fisiologia dos Nervos Periféricos(2016) FERNANDES, Frederico leon Arrabal; SALGE, João Marcos- Espirometria em pacientes submetidos a investigação para detecção de doença arterial coronariana: é útil?(2018) FERNANDES, Frederico Leon Arrabal; CARVALHO-PINTO, Regina Maria; STELMACH, Rafael; SALGE, Joao Marcos; ROCHITTE, Carlos Eduardo; SOUZA, Eliane Cardoso dos Santos; PESSI, Janaina Danielle; CUKIER, AlbertoObjetivo: Determinar a prevalência de alterações espirométricas em pacientes submetidos a investigação para detecção de doença arterial coronariana (DAC) e os fatores de risco de comprometimento da função pulmonar. Métodos: Pacientes encaminhados para TC cardíaca foram submetidos a espirometria e, em seguida, divididos em dois grupos: função pulmonar normal e função pulmonar anormal. A prevalência de alterações espirométricas foi calculada em fumantes, pacientes com síndrome metabólica, idosos e portadores de lesões coronárias obstrutivas. Os grupos e subgrupos foram comparados quanto ao escore de cálcio coronariano e ao índice de gravidade de DAC de Duke. Resultados: Completaram o estudo 205 pacientes. Destes, 147 (72%) apresentaram função pulmonar normal e 58 (28%) apresentaram função pulmonar anormal. A mediana do escore de cálcio coronariano foi 1 nos pacientes com função pulmonar normal e 36 naqueles com função pulmonar anormal (p = 0,01). A média do índice de gravidade de DAC de Duke foi = 15 nos pacientes com função pulmonar normal e 27 nos pacientes com função pulmonar anormal (p < 0,01). O tabagismo apresentou a maior OR de função pulmonar anormal, seguido de idade > 65 anos e lesões coronarianas obstrutivas. Conclusões: A prevalência de alterações espirométricas parece ser alta em pacientes submetidos a TC cardíaca para detecção de DAC. O risco de função pulmonar anormal é maior em fumantes, idosos e pacientes com DAC, os quais, portanto, devem ser submetidos a espirometria. (ClinicalTrials.gov identifier: NCT01734629 [http://www.clinicaltrials.gov/])
conferenceObject Prevalence Of Dinamic Hyperinflation And Aerobic Capacity Assessment In Bronchiectasis Patients(2017) NUCCI, M. N. Maiorano De; FERNANDES, F. L. A.; ATHANAZIO, R. A.; SALGE, J. M.; STELMACH, R.; CUKIER, A.conferenceObject Heterogeneity of small airways flow and hyperinflation are markers of a persistent obstruction phenotype in severe non-controlled asthmatics(2012) CARVALHO-PINTO, Regina Maria; CUKIER, Alberto; ANGELINI, Luciene; FERNANDES, Frederico Leon Arrabal; SALGE, Joao Marcos; STELMACH, Rafael- The effects of exercise training in a weight loss lifestyle intervention on asthma control, quality of life and psychosocial symptoms in adult obese asthmatics: protocol of a randomized controlled trial(2015) FREITAS, Patricia D.; FERREIRA, Palmira G.; SILVA, Analuci da; TRECCO, Sonia; STELMACH, Rafael; CUKIER, Alberto; CARVALHO-PINTO, Regina; SALGE, Joao Marcos; FERNANDES, Frederico L. A.; MANCINI, Marcio C.; MARTINS, Milton A.; CARVALHO, Celso R. F.Background: Asthma and obesity are public health problems with increasing prevalence worldwide. Clinical and epidemiologic studies have demonstrated that obese asthmatics have worse clinical control and health related quality of life (HRQL) despite an optimized medical treatment. Bariatric surgery is successful to weight-loss and improves asthma control; however, the benefits of nonsurgical interventions remain unknown. Methods/Design: This is a randomized controlled trial with 2-arms parallel. Fifty-five moderate or severe asthmatics with grade II obesity (BMI >= 35 kg/m(2)) under optimized medication will be randomly assigned into either weight-loss program + sham (WL + S group) or weight-loss program + exercise (WL + E group). The weight loss program will be the same for both groups including nutrition and psychological therapies (every 15 days, total of 6 sessions, 60 min each). Exercise program will include aerobic and resistance muscle training while sham treatment will include a breathing and stretching program (both programs twice a week, 3 months, 60 min each session). The primary outcome variable will be asthma clinical control. Secondary outcomes include HRQL, levels of depression and anxiety, lung function, daily life physical activity, body composition, maximal aerobic capacity, strength muscle and sleep disorders. Potential mechanism (changes in lung mechanical and airway/systemic inflammation) will also be examined to explain the benefits in both groups. Discussion: This study will bring a significant contribution to the literature evaluating the effects of exercise conditioning in a weight loss intervention in obese asthmatics as well as will evaluate possible involved mechanisms.