DANIELLE SOARES BIO
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
2 resultados
Resultados de Busca
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- Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: an individual patient data meta-analysis(2013) BOURNE, C.; AYDEMIR, O.; BALANZA-MARTINEZ, V.; BORA, E.; BRISSOS, S.; CAVANAGH, J. T. O.; CLARK, L.; CUBUKCUOGLU, Z.; DIAS, V. V.; DITTMANN, S.; FERRIER, I. N.; FLECK, D. E.; FRANGOU, S.; GALLAGHER, P.; JONES, L.; KIESEPPA, T.; MARTINEZ-ARAN, A.; MELLE, I.; MOORE, P. B.; MUR, M.; PFENNIG, A.; RAUST, A.; SENTURK, V.; SIMONSEN, C.; SMITH, D. J.; BIO, D. S.; SOEIRO-DE-SOUZA, M. G.; STODDART, S. D. R.; SUNDET, K.; SZOKE, A.; THOMPSON, J. M.; TORRENT, C.; ZALLA, T.; CRADDOCK, N.; ANDREASSEN, O. A.; LEBOYER, M.; VIETA, E.; BAUER, M.; WORHUNSKY, P. D.; TZAGARAKIS, C.; ROGERS, R. D.; GEDDES, J. R.; GOODWIN, G. M.Objective: An association between bipolar disorder and cognitive impairment has repeatedly been described, even for euthymic patients. Findings are inconsistent both across primary studies and previous meta-analyses. This study reanalysed 31 primary data sets as a single large sample (N = 2876) to provide a more definitive view. Method: Individual patient and control data were obtained from original authors for 11 measures from four common neuropsychological tests: California or Rey Verbal Learning Task (VLT), Trail Making Test (TMT), Digit Span and/or Wisconsin Card Sorting Task. Results: Impairments were found for all 11 test-measures in the bipolar group after controlling for age, IQ and gender (Ps <= 0.001, E.S. = 0.26-0.63). Residual mood symptoms confound this result but cannot account for the effect sizes found. Impairments also seem unrelated to drug treatment. Some test-measures were weakly correlated with illness severity measures suggesting that some impairments may track illness progression. Conclusion: This reanalysis supports VLT, Digit Span and TMT as robust measures of cognitive impairments in bipolar disorder patients. The heterogeneity of some test results explains previous differences in meta-analyses. Better controlling for confounds suggests deficits may be smaller than previously reported but should be tracked longitudinally across illness progression and treatment.
- The CACNA1C risk allele selectively impacts on executive function in bipolar type I disorder(2013) SOEIRO-DE-SOUZA, M. G.; BIO, D. S.; DIAS, V. V.; VIETA, E.; MACHADO-VIEIRA, R.; MORENO, R. A.ObjectiveCalcium channels are important for converting electrical activity into biochemical events. A single nucleotide polymorphism (SNP) (rs1006737) in the CACNA1C gene has been strongly associated with increased risk for Bipolar disorder (BD) in genome-wide association studies. Recently, this same SNP has been reported to influence executive function in schizophrenia and controls, but it remains unclear whether this SNP affects behaviour, especially cognition in subjects with BD. MethodA total of 109 BD type I subjects and 96 controls were genotyped for CACNA1C rs1006737 and assessed with an executive function tests battery [Wechsler Adult Intelligence Scale III (WAIS-III) Letter-Number Sequence subtest (WAIS-LNS), digit span (WAISDS), trail making test (TMT), and WCST (Wisconsin Card Sorting Test)]. ResultsIn patients with BD, the CACNA1C genotype Met/Met was associated with worse performance on all four executive function tests compared to Val/Val. No influence of CACNA1C was observed in the cognitive performance of healthy controls. ConclusionOur data indicate for the first time that the CACNA1C risk allele is likely associated with executive dysfunction as a trait in BD, as this association was found regardless the presence of mood symptoms. Larger studies should evaluate the potential influence of CACNA1C on other cognitive domains in BD.