ANA GABRIELA HOUNIE
Projetos de Pesquisa
Unidades Organizacionais
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
4 resultados
Resultados de Busca
Agora exibindo 1 - 4 de 4
- Association study between functional polymorphisms in the TNF-alpha gene and obsessive-compulsive disorder(2012) CAPPI, Carolina; MUNIZ, Renan Kawano; SAMPAIO, Aline Santos; CORDEIRO, Quirino; BRENTANI, Helena; PALACIOS, Selma A.; MARQUES, Andrea H.; VALLADA, Homero; MIGUEL, Euripedes Constantino; GUILHERME, Luiza; HOUNIE, Ana GabrielaObsessive-compulsive disorder (OCD) is a prevalent psychiatric disorder of unknown etiology. However, there is some evidence that the immune system may play an important role in its pathogenesis. In the present study, two polymorphisms (rs1800795 and rs361525) in the promoter region of the cytokine tumor necrosis factor-alpha (TNFA) gene were genotyped in 183 OCD patients and in 249 healthy controls. The statistical tests were performed using the PLINK (R) software. We found that the A allele of the TNFA rs361525 polymorphism was significantly associated with OCD subjects, according to the allelic x association test (p=0.007). The presence of genetic markers, such as inflammatory cytokines genes linked to OCD, may represent additional evidence supporting the rote of the immune system in its pathogenesis.
- Comorbid major depression in obsessive-compulsive disorder patients(2011) QUARANTINI, Lucas C.; TORRES, Albina Rodrigues; SAMPAIO, Aline S.; FOSSALUZA, Victor; MATHIS, Maria Alice de; ROSARIO, Maria Conceicao do; FONTENELLE, Leonardo F.; FERRAO, Ygor A.; CORDIOLI, Aristides Volpato; PETRIBU, Katia; HOUNIE, Ana G.; MIGUEL, Euripedes C.; SHAVITT, Roseli G.; KOENEN, Karestan C.Although major depressive disorder (MDD) has been consistently considered the most frequent complication of obsessive-compulsive disorder (OCD), little is known about the clinical characteristics of patients with both disorders. This study assessed 815 Brazilian OCD patients using a comprehensive psychiatric evaluation. Clinical and demographic variables, including OCD symptom dimensions, were compared among OCD patients with and without MDD. Our findings showed that prevalence rates of current MDD (32%) and lifetime MDD (67.5%) were similar for both sexes in this study. In addition, patients with comorbid MDD had higher severity scores of OCD symptoms. There was no preferential association of MDD with any particular OCD symptom dimension. This study supports the notion that depressed OCD patients present more severe general psychopathology.
- Clinical features of tic-related obsessive-compulsive disorder: results from a large multicenter study(2012) ALVARENGA, Pedro Gomes de; MATHIS, Maria Alice de; ALVES, Anna Claudia Dominguez; ROSARIO, Maria Conceicao do; FOSSALUZA, Victor; HOUNIE, Ana Gabriela; MIGUEL, Euripedes Constantino; TORRES, Albina RodriguesObjective. To evaluate the clinical features of obsessive-compulsive disorder (OCD) patients with comorbid tic disorders (TD) in a large, multicenter, clinical sample. Method. A cross-sectional study was conducted that included 813 consecutive OCD outpatients from the Brazilian OCD Research Consortium and used several instruments of assessment, including the Yale-Brown Obsessive-Compulsive Scale, the Dimensional Yale-Brown Obsessive-Compulsive Scale, the Yale Global Tic Severity Scale (YGTSS), the USP Sensory Phenomena Scale, and the Structured Clinical Interview for DSM-IV Axis I Disorders. Results. The sample mean current age was 34.9 years old (SE 0.54), and the mean age at obsessive-compulsive symptoms (OCS) onset was 12.8 years old (SE 0.27). Sensory phenomena were reported by 585 individuals (72% of the sample). The general lifetime prevalence of TD was 29.0% (n=236), with 8.9% (n=72) presenting Tourette syndrome, 17.3% (n=5141) chronic motor tic disorder, and 2.8% (n=523) chronic vocal tic disorder. The mean tic severity score, according to the YGTSS, was 27.2 (SE 1.4) in the OCD1TD group. Compared to OCD patients without comorbid TD, those with TD (OCD1TD group, n=236) were more likely to be males (49.2% vs. 38.5%, p<005) and to present sensory phenomena and comorbidity with anxiety disorders in general: separation anxiety disorder, social phobia, specific phobia, generalized anxiety disorder, post-traumatic stress disorder, attention-deficit hyperactivity disorder, impulse control disorders in general, and skin picking. Also, the ""aggressive,"" ""sexual/religious,"" and ""hoarding"" symptom dimensions were more severe in the OCD+TD group. Conclusion. Tic-related OCD may constitute a particular subgroup of the disorder with specific phenotypical characteristics, but its neurobiological underpinnings remain to be fully disentangled.
- Sex differences in the genetic architecture of obsessive-compulsive disorder(2019) KHRAMTSOVA, Ekaterina A.; HELDMAN, Raphael; DERKS, Eske M.; YU, Dongmei; DAVIS, Lea K.; STRANGER, Barbara E.; ARNOLD, Paul D.; ASKLAND, Kathleen D.; BARLASSINA, Cristina; BELLODI, Laura; BIENVENU, O. J.; BLACK, Donald; BLOCH, Michael; BRENTANI, Helena; BURTON, Christie L.; CAMARENA, Beatriz; CAPPI, Carolina; CATH, Danielle; CAVALLINI, Maria; CONTI, David; COOK, Edwin; CORIC, Vladimir; CULLEN, Bernadette A.; CUSI, Danielle; DAVIS, Lea K.; DELORME, Richard; DENYS, Damiaan; DERKS, Eske; EAPEN, Valsamma; EDLUND, Christopher; ERDMAN, Lauren; FALKAI, Peter; FIGEE, Martijn; FYER, Abigail J.; GELLER, Daniel A.; GOES, Fernando S.; GRABE, Hans; GRADOS, Marcos A.; GREENBERG, Benjamin D.; GRUNBLATT, Edna; GUO, Wei; HANNA, Gregory L.; HEMMINGS, Sian; HOUNIE, Ana G.; JENICKE, Michael; KEENAN, Clare; KENNEDY, James; KHRAMTSOVA, Ekaterina A.; KONKASHBAEV, Anuar; KNOWLES, James A.; KRASNOW, Janice; LANGE, Cristophe; LANZAGORTA, Nuria; LEBOYER, Marion; LENNERTZ, Leonhard; LI, Bingbin; LIANG, K-Y; LOCHNER, Christine; MACCIARDI, Fabio; MAHER, Brion; MAIER, Wolfgang; MARCONI, Maurizio; MATHEWS, Carol A.; MATTHESIEN, Manuel; MCCRACKEN, James T.; MCLAUGHLIN, Nicole C.; MIGUEL, Euripedes C.; MOESSNER, Rainald; MURPHY, Dennis L.; NEALE, Benjamin; NESTADT, Gerald; NESTADT, Paul; NICOLINI, Humberto; NURMI, Ericka; OSIECKI, Lisa; PATO, Carlos; PATO, Michelle; PAULS, David L.; PIACENTINI, John; POSTHUMA, Danielle; PULVER, Ann E.; QIN, H-D; RASMUSSEN, Steven A.; RAUCH, Scott; RICHTER, Margaret A.; RIDDLE, Mark A.; RIPKE, Stephan; RUHRMANN, Stephan; SAMPAIO, Aline S.; SAMUELS, Jack F.; SCHARF, Jeremiah M.; SHUGART, Yin Yao; SMIT, Jan; STEIN, Daniel; STEWART, S. Evelyn; TURIEL, Maurizio; VALLADA, Homero; VEENSTRA-VANDERWEELE, Jeremy; WAGNER, Michael; WALITZA, Susanne; WANG, Y.; WENDLAND, Jens; VULINK, Nienke; YU, Dongmei; ZAI, GwynethObsessive-compulsive disorder (OCD) is a highly heritable complex phenotype that demonstrates sex differences in age of onset and clinical presentation, suggesting a possible sex difference in underlying genetic architecture. We present the first genome-wide characterization of the sex-specific genetic architecture of OCD, utilizing the largest set of OCD cases and controls available from the Psychiatric Genomics Consortium. We assessed evidence for several mechanisms that may contribute to sex differences including a sex-dependent liability threshold, the presence of individual sex-specific risk variants on the autosomes and the X chromosome, and sex-specific pleiotropic effects. Furthermore, we tested the hypothesis that genetic heterogeneity between the sexes may obscure associations in a sex-combined genome-wide association study. We observed a strong genetic correlation between male and female OCD and no evidence for a sex-dependent liability threshold model, suggesting that sex-combined analysis does not suffer from widespread loss of power because of genetic heterogeneity between the sexes. While we did not detect any significant sex-specific genome-wide single nucleotide polymorphisms (SNP) associations, we did identify two significant gene-based associations in females: GRID2 and GRP135, which showed no association in males. We observed that the SNPs with sexually differentiated effects showed an enrichment of regulatory variants influencing expression of genes in brain and immune tissues. These findings suggest that future studies with larger sample sizes hold great promise for the identification of sex-specific genetic risk factors for OCD.