JOZELIO FREIRE DE CARVALHO
Projetos de Pesquisa
Unidades Organizacionais
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
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bookPart 0 Citação(ões) na Scopus Vitamin K: Metabolism, sources and interaction with foods and oral anticoagulants(2012) KLACK, K.; CARVALHO, J. F.Vitamin K is a fat-soluble vitamin that is primarily involved in blood coagulation. Vitamin K denotes a group of the following substances: Phylloquinone (K1- predominant), Dihydrophylloquinone (dK), Menaquinone (K2) and Menadione (K3). The absorption of vitamin K is affected by several conditions, such as poor gastrointestinal absorption, biliary secretion and insufficient dietary intake. The main sources of vitamin K are vegetables and oils, and phylloquinone is the major dietary form of vitamin K. Dark green leafy vegetables, foods cooked in oil, oilseeds and fruits such as kiwis, avocados, grapes, plums and figs contain high levels of vitamin K. On the other hand, cereals, grains, breads and dairy products contain low levels of vitamin K. The daily intake of approximately 1 μg of vitamin K per kilo of body weight is considered safe, even in the case of oral anticoagulant use; a stable concentration of the vitamin helps to increase the efficacy of treatment. Warfarin is the most commonly used anticoagulant drug and is used as both prophylaxis and therapy for the treatment of thromboembolic complications. The use of warfarin is monitored by the prothrombin time, which is expressed as the international normalized ratio (INR). The aim of this monitoring is to set a therapeutic range of the INR of 2-3 in order to minimize the risk of hemorrhaging. The anticoagulation effect may be reduced by weight gain, diarrhea, vomiting, being under 40 years of age and excessive dietary intake of vitamin K. © 2012 Nova Science Publishers, Inc.bookPart Miopatias(2013) CARVALHO, Jozélio Freire debookPart 0 Citação(ões) na Scopus Vogt-Koyanagi-Harada disease(2011) CARVALHO, J. F. de; SOUZA, A. W. de; YAMAMOTO, J. H.; APPENZELLER, S.The term panuveitis is reserved for diseases that involve all segments of the uveal tract, including the retina and vitreous body. It is usually associated with severe sight-threatening inflammatory response. The common causes of panuveitis in our population are tuberculosis, syphilis, Vogt-Koyanagi-Harada disease, sympathetic ophthalmia, Behçet’s disease and sarcoidosis. Vogt-Koyanagi-Harada disease (VKH) is a multisystem autoimmune disorder affecting pigmented tissues such as the eye, auditory, integumentary and central nervous systems. Patients are typically females between 20 to 50 years old with no previous history of penetrating ocular trauma. Despite the increasing reports published about the clinical features of VKHdisease in various ethnic populations, the etiology of VKH disease is still not completely known. Clinical, laboratorial, experimental data corroborate to the autoimmune nature of VKH disease in a genetically susceptible individual. A stepwise approach is essential while evaluating these patients to be able to identify and treat the disease timely and adequately. Ancillary tests can be appropriately applied once the clinical diagnosis is made. Treatment is based on initial high-dose oral corticosteroids with a low tapering during a minimum period of 6 months. Systemic immunomodulatory agents such as cyclosporine may be used in refractory or corticosteroid non-tolerant patients. Visual prognosis is usually good under a prompt diagnosis and adequate treatment. The aim of this paper is to review the latest research results on VKH disease in order to help to understand better this potentially blinding disease and to improve treatment. © 2011 Nova Science Publishers, Inc.