MICHELLE DA SILVA

Índice h a partir de 2011
3
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Unidades Organizacionais
Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina

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Assunto: Psychiatry ×

Resultados de Busca

Agora exibindo 1 - 8 de 8
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    Exercise and ventilatory threshold in bipolar depression: A pilot study
    (2019) DUARTE, C.; SILVA, M.; ALMEIDA, K.; GREVE, J.; SILVA, P.; LAFER, B.
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    Quality of life is associated with clinical outcome in BD: a longitudinal study
    (2018) SILVA, M.; BELIZARIO, G. O.; ABREU, L. N.; LAFER, B.
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    A randomized, double-blind, placebo-controlled trial of creatine monohydrate as adjunctive treatment for bipolar depression
    (2017) TONIOLO, R. A.; SILVA, M.; FERNANDES, F. B. F.; AMARAL, J. A. M. S.; DIAS, R. S.; LAFER, B.
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  • article 18 Citação(ões) na Scopus
    Cognitive effects of creatine monohydrate adjunctive therapy in patients with bipolar depression: Results from a randomized, double-blind, placebo-controlled trial
    (2017) TONIOLO, Ricardo Alexandre; FERNANDES, Francy de Brito Ferreira; SILVA, Michelle; DIAS, Rodrigo da Silva; LAFER, Beny
    Background: Depressive episodes and cognitive impairment are major causes of morbidity and dysfunction in individuals suffering from bipolar disorder (BD). Novel treatment approaches that target clinical and cognitive aspects of bipolar depression are needed, and research on pathophysiology suggests that mitochondrial modulators such as the nutraceutical creatine monohydrate might have a therapeutic role for this condition. Methods: Eighteen (N=18) patients with bipolar depression according to DSM-IV criteria who were enrollled in a 6-week, randomized, double-blind, placebo-controlled trial of creatine monohydrate 6 g daily as adjunctive therapy were submitted to neuropsychological assessments (Wisconsin Card Sorting Test, Digit Span subtest of the Wechsler Adult Intelligence Scale-Third Edition, Stroop Color-Word Test, Rey-Osterrieth complex figure test, FAS Verbal Fluency Test) at baseline and week 6. Results: There was a statistically significant difference between the treatment groups of the change on the total scores after 6 weeks in the verbal fluency test, with improvement in the group receiving adjunctive treatment with creatine. We did not find significant differences between the groups of the changes on other neuropsychological tests. Limitations: Small sample and lack of a control group of healthy subjects. Conclusions: Our trial, which was the first to investigate the cognitive effects of creatine monohydrate on bipolar depression, indicates that supplementation with this nutraceutical for 6 weeks is associated with improvement in verbal fluency tests in patients with this condition.
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    Lithium may induce changes in renal tubular function and calcium homeostasis in patients with bipolar disorder
    (2017) HORTENCIO, L.; HELOU, C. M.; SILVA, M.; LAFER, B.; ALMEIDA, K.
  • article 13 Citação(ões) na Scopus
    Impact of predominant polarity on long-term outcome in bipolar disorder: A 7-year longitudinal cohort study
    (2018) BELIZARIO, Gabriel Okawa; SILVA, Michelle; LAFER, Beny
    Introduction: Recent studies suggest that Predominant Polarity (PP) may be an important specifier of Bipolar Disorder (BD), establishing distinct groups of patients and providing a potential tool for tailored treatment. PP has been associated to various clinical variables present in the course of the disorder, including deficits in cognitive functioning, suicide attempts, hospitalizations and response to pharmacological treatment. However, most published studies are retrospective and cross-sectional, frequently relying on patients' ability to recall past information, which may often be inaccurate. Methods: Participants were recruited from the outpatient clinic of the Bipolar Disorder Research Program at the Institute of Psychiatry of the University of Sao Paulo. Baseline clinical and demographic variables were collected using a semi-structured questionnaire and the SCID-CV. Longitudinal data were collected through medical records, mood charts, and mood symptom scales conducted throughout a 7-year follow-up period. Results: Manic Predominant Polarity (MPP) was associated with a significantly higher number of hospitalizations, suicide attempts, and episodes with psychotic symptoms throughout the 7-year observed period in comparison to Depressive Predominant Polarity (DPP) and Indefinite Predominant Polarity (IPP) patients. Moreover, baseline PP was significantly associated with 7-year PP, with 67% of patients maintaining their PP both at baseline and after the 7-year follow-up period. Limitations: The present study is limited due to the statistically small sample size, although, to our knowledge, it is the largest longitudinal study conducted in this topic, and the unequally distributed frequency of patients' visitations, which may have created intervals of unobserved periods within the follow-up period. Discussion: The results revealed PP to be an important specifier for predicting the course of the disorder. Overall, MPP was significantly associated with variables indicative of a worse outcome, suggesting that greater attention to preventive treatment should be addressed to this subgroup. Lastly, baseline PP was significantly associated with 7-year observed PP, suggesting that patients tend to remain within the same PP throughout the course of the disorder.