ALMIR FERREIRA DE ANDRADE
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/62 - Laboratório de Fisiopatologia Cirúrgica, Hospital das Clínicas, Faculdade de Medicina
LIM/62 - Laboratório de Fisiopatologia Cirúrgica, Hospital das Clínicas, Faculdade de Medicina
8 resultados
Resultados de Busca
Agora exibindo 1 - 8 de 8
- Evaluation of the Maintained Effect of 3% Hypertonic Saline Solution in an Animal Model of Intracranial Hypertension(2016) SOUSA JR., Leonardo M.; ANDRADE, Almir F. de; BELON, Alessandro R.; SOARES, Matheus S.; AMORIM, Robson Luis; OTOCHI, Jose Pinhata; TEIXEIRA, Manoel J.; PAIVA, Wellingson S.Background: Current clinical treatment methods for refractory intracranial hypertension include elevation of the decubitus, ventilation adjustment, and use of hypertonic solutions such as hypertonic saline and mannitol solutions. Previous studies have shown that hypertonic solutions are particularly effective. Although several concentrations of saline solution have been proposed, a 3% solution is the most widely used. The aim of this study was to evaluate the maintained efficacy of a 3% hypertonic saline solution in an experimental model of intracranial hypertension. Material/Methods: A porcine model of reversible intracranial hypertension was created by inserting a balloon catheter into the brain parenchyma, which was inflated and deflated to simulate intracranial hypertension and its surgical correction. The experiment included 3 groups of animals (A, B, and C) with different balloon inflation volumes. In group B, balloons were inflated 2 times to simulate reexpansion. A 20 mL/kg bolus of 3% saline solution was infused using a pump 90 minutes after the start of balloon inflation, and the effects of intracranial pressure were evaluated 60 minutes after infusion. Results: No increases outside of the normal range were observed in mean serum sodium concentrations (p=0.09). In addition, we identified no differences within each group in serum sodium levels measured during hypertonic saline infusion (p=0.21). No significant reductions in intracranial pressure were observed in any of the 3 groups. Conclusions: Bolus infusion of 3% hypertonic saline solution with the aid of a pump does not significantly reduce intracranial pressure in an animal model of intracranial hypertension.
bookPart CARACETRIZAÇÃO E CONDUTA NO TRAUMATISMO CRANIOENCEFÁLICO LEVE(2016) ANDRADE, Almir Ferreira de; PAIVA, Wellingson Silva; FIGUEIREDO, Eberval Gadelha; SANTOS, João Gustavo Rocha Peixoto dos; TEIXEIRA, Manoel Jacobsen- Diffuse Axonal Injury: Epidemiology, Outcome and Associated Risk Factors(2016) VIEIRA, Rita de Cassia Almeida; PAIVA, Wellingson Silva; OLIVEIRA, Daniel Vieira de; TEIXEIRA, Manoel Jacobsen; ANDRADE, Almir Ferreira de; SOUSA, Regina Marcia Cardoso deDiffuse axonal injury (DAI), a type of traumatic injury, is known for its severe consequences. However, there are few studies describing the outcomes of DAI and the risk factors associated with it. This study aimed to describe the outcome for patients with a primary diagnosis of DAI 6 months after trauma and to identify sociodemographic and clinical factors associated with mortality and dependence at this time point. Seventy-eight patients with DAI were recruited from July 2013 to February 2014 in a prospective cohort study. Patient outcome was analyzed using the Extended Glasgow Outcome Scale (GOS-E) within 6 months of the traumatic injury. The mean Injury Severity Score was 35.0 (SD = 11.9), and the mean New Injury Severity Score (NISS) was 46.2 (SD = 15.9). Mild DAI was observed in 44.9% of the patients and severe DAI in 35.9%. Six months after trauma, 30.8% of the patients had died, and 45.1% had shown full recovery according to the GOS-E. In the logistic regression model, the severity variables - DAI with hypoxia, as measured by peripheral oxygen saturation, and hypotension with NISS value - had a statistically significant association with patient mortality; on the other hand, severity of DAI and length of hospital stay were the only significant predictors for dependence. Therefore, severity of DAI emerged as a risk factor for both mortality and dependence.
- Current clinical approach to patients with disorders of consciousness(2016) AMORIM, Robson Luis Oliveira de; NAGUMO, Marcia Mitie; PAIVA, Wellingson Silva; ANDRADE, Almir Ferreira de; TEIXEIRA, Manoel JacobsenSummary In clinical practice, hospital admission of patients with altered level of consciousness, sleepy or in a non-responsive state is extremely common. This clinical condition requires an effective investigation and early treatment. Performing a focused and objective evaluation is critical, with quality history taking and physical examination capable to locate the lesion and define conducts. Imaging and laboratory exams have played an increasingly important role in supporting clinical research. In this review, the main types of changes in consciousness are discussed as well as the essential points that should be evaluated in the clinical management of these patients.
- The Bone Flap Dilemma in Acute Subdural Hematoma Surgery(2016) BEER-FURLAN, Andre; PAIVA, Wellingson Silva; ANDRADE, Almir Ferreira de; FIGUEIREDO, Eberval Gadeiha
- Traumatic Brain Injury Research in Brazil: A Bibliometric Study(2016) AMORIM, Robson Luis; TEIXEIRA, Saulo Araujo; SILVA-NETO, Sergio Goncalves; ANGHINAH, Renato; TEIXEIRA, Manoel Jacobsen; ANDRADE, Almir Ferreira de; PAIVA, Wellingson SilvaTraumatic brain injury (TBI) is responsible for high rates of morbidity and mortality, constituting an important public health problem throughout the world. Improving medical research on systemic trauma is a critical issue to understand its impact and develop strategies for prevention and treatment. This paper presents an overview of medical research performed in Brazil about TBI comparing it with the production on the same topic with other countries and with publications about different neurological and non-neurological diseases. It is possible to notice that Brazil has a deficiency in the scientific production on TBI given its importance. Greater integration between the research centers could help meliorate the production and quality of the papers and encourage further studies on the theme, in the quest to minimize the shortage of publications that can be seen today.
- Plasma Level of Homocysteine in Traumatic Brain Injury(2016) PAIVA, Wellingson da Silva; ANDRADE, Almir Ferreira de; TEIXEIRA, Manoel Jacobsen
- Virtual reality for the treatment of posttraumatic disorders(2016) MORAES, Thiago Mazzoli; ANDRADE, Almir Ferreira de; PAIVA, Wellingson Silva