EDUARDO BELLO MARTINS
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
11 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 11
- APPLICATION OF SYNTAX SCORE I, II AND RESIDUAL SYNTAX AS PREDICTORS OF LONG-TERM CLINICAL OUTCOMES AFTER CORONARY ARTERY BYPASS GRAFTING(2019) MARTINS, Eduardo; HUEB, Whady; LIMA, Eduardo Gomes; CARVALHO, Guilherme Fernandes; DALLAZEN, Anderson Roberto; LINHARES FILHO, Jaime; BATISTA, Daniel Valente; SILVA, Rafael; AZEVEDO, Diogo Freitas Cardoso; REZENDE, Paulo; RAMIRES, Jose; KALIL FILHO, Roberto
- Effect of diabetic kidney disease on therapeutic strategies for coronary artery disease: ten year follow-up(2021) BATISTA, Daniel Valente; HUEB, Whady; LIMA, Eduardo Gomes; REZENDE, Paulo Cury; GARZILLO, Cibele Larrosa; GARCIA, Rosa Maria Rahmi; LINHARES FILHO, Jaime Paula Pessoa; MARTINS, Eduardo Bello; SERRANO JUNIOR, Carlos Vicente; RAMIRES, Jose Antonio Franchini; KALIL FILHO, RobertoBackground: The best treatment for coronary artery disease (CAD) in patients with type 2 diabetes (DM2) and chronic kidney disease is unknown. Methods: This retrospective study included MASS registry patients with DM2 and multivessel CAD, stratified by kidney function. Primary endpoint was combined of mortality, myocardial infarction, or additional revascularization. Results: Median follow-up was 9.5 years. Primary endpoint occurrences among strata 1 and 2 were 53.4% and 40.7%, respectively (P=.020). Mortality rates were 37.4% and 24.6% in strata 1 and 2, respectively (P<.001). We observed a lower rate of major adverse cardiovascular events (MACE) (P=.027 for stratum 1 and P<.001 for stratum 2) and additional revascularization (P=.001 for stratum 1 and P<.001 for stratum 2) for those in the surgical group. In a multivariate analysis, eGFR was an independent predictor of MACE (P=.034) and mortality (P=.020). Conclusions: Among subjects with DM2 and CAD the presence of lower eGFR rate was associated with higher rates of MACE and mortality, irrespective of treatment choice. CABG was associated with lower rates of MACE in both renal function strata. eGFR was an independent predictor of MACE and mortality in a 10-year follow-up.
- Significant association of SYNTAX score on release of cardiac biomarkers in uncomplicated post-revascularization procedures among patients with stable multivessel disease MASS-V Study group(2020) AZEVEDO, Diogo Freitas Cardoso de; HUEB, Whady; LIMA, Eduardo Gomes; REZENDE, Paulo Cury; LINHARES FILHO, Jaime Paula Pessoa; CARVALHO, Guilherme Fernandes de; MARTINS, Eduardo Bello; NOMURA, Cesar Higa; STRUNZ, Celia Maria Cassaro; SERRANO JUNIOR, Carlos Vicente; RAMIRES, Jose Antonio Franchini; KALIL FILHO, RobertoThis study investigated the relationship between angiographic complexities of coronary artery disease (CAD) assessed by SYNTAX Score synergy between percutaneous coronary intervention with taxus and cardiac surgery score (SYNTAX Score) and cardiac biomarker elevation after revascularization procedures. This is a post-hoc analysis of the medicine, angioplasty or surgery study V study of patients with stable CAD. High-sensitivity troponin 1 (hs-TnI) and creatinine kinase-muscle/brain (CK-MB) were assessed before and after cardiovascular procedures. Baselines SYNTAX Scores (SXScores) were calculated by blinded investigators to patient characteristics. Of the 202 patients studied, the mean SXScore was 21.25 +/- 9.24; 40.10 +/- 7.09 in the high SXScore group and 19.06 +/- 6.61 in low/mid SXscore group (P < .0001). Positive correlations existed between SXScore and median peaks after procedural hs-TnI (r = 0.18, P = .009) and CK-MB (r = 0.24, P = .001) levels. In patients with high SXScores (>= 33), the median peaks of post-procedural hs-TnI (P = .034)and CK-MB (P = .004) levels were higher than in low/mid SXScore group (<33).The release of hs-TnI at 6 (P = .002), 12 (P = .008), and 24 hours (P = .039) was higher in high SXScore group than in low/mid SXscore group (<33) as was the release of CK-MB at 6 (P < .0001), 12 (P < .0001), 24 (P = .001), 36 (P = .007), 48 (P = .008), and 72 hours (P = .023). After multivariable analysis, high SXScore was a significant independent predictor of release of CK-MB and hs-TnI peaks higher than the median. The increase in release of cardiac biomarkers was significantly associated with the extent of atherosclerosis identified by the SYNTAX Score.
conferenceObject Cardiac Biomarkers Elevation After Myocardial Revascularization Predicts Cardiovascular Prognosis. Long-Term Follow-Up of Mass-V Study(2018) LINHARES FILHO, Jaime P.; HUEB, Whady; V, Daniel Batista; LIMA, Eduardo G.; SILVA, Rafael R.; REZENDE, Paulo C.; STRUNZ, Celia M.; MARTINS, Eduardo B.; GARZILLO, Cibele L.; AZEVEDO, Diogo F.; DALLAZEN, Anderson R.; RIBAS, Fernando F.; RAMIRES, Jose A.; KALIL FILHO, Roberto- Long-term outcomes of patients with stable coronary disease and chronic kidney dysfunction: 10-year follow-up of the Medicine, Angioplasty, or Surgery Study II Trial(2020) LIMA, Eduardo Gomes; CHARYTAN, David M.; HUEB, Whady; AZEVEDO, Diogo Freitas Cardoso de; GARZILLO, Cibele Larrosa; FAVARATO, Desiderio; LINHARES FILHO, Jaime Paula Pessoa; MARTINS, Eduardo Bello; BATISTA, Daniel Valente; REZENDE, Paulo Cury; HUEB, Alexandre Ciappina; RAMIRES, Jose Antonio Franchini; KALIL FILHO, RobertoBackground. Chronic kidney disease (CKD) is associated with a worse prognosis in patients with stable coronary artery disease (CAD); however, there is limited randomized data on long-term outcomes of CAD therapies in these patients. We evaluated long-term outcomes of CKD patients with CAD who underwent randomized therapy with medical treatment (MT) alone, percutaneous coronary intervention (PCI) or coronary artery bypass graft surgery (CABG). Methods. Baseline estimated glomerular filtration rate (eGFR) was obtained in 611 patients randomized to one of three therapeutic strategies in the Medicine, Angioplasty, or Surgery Study II trial. Patients were categorized in preserved renal function and mild or moderate CKD groups depending on their eGFR (>= 90, 89-60 and 59-30 mL/min/1.73 m(2), respectively). The primary clinical endpoint, a composite of overall death and myocardial infarction, and its individual components were analyzed using proportional hazards regression (Clinical Trial registration information: http://www.controlled-trials.com.Registration number: ISRCTN66068876). Results. Of 611 patients, 112 (18%) had preserved eGFR, 349 (57%) mild dysfunction and 150 (25%) moderate dysfunction. The primary endpoint occurred in 29.5, 32.4 and 44.7% (P = 0.02) for preserved eGFR, mild CKD and moderate CKD, respectively. Overall mortality incidence was 18.7, 23.8 and 39.3% for preserved eGFR, mild CKD and moderate CKD, respectively (P = 0.001). For preserved eGFR, there was no significant difference in outcomes between therapies. For mild CKD, the primary event rate was 29.4% for PCI, 29.1% for CABG and 41.1% for MT (P = 0.006) [adjusted hazard ratio (HR) = 0.26, 95% confidence interval (CI) 0.07-0.88; P = 0.03 for PCI versus MT; and adjusted HR = 0.48; 95% CI 0.31-0.76; P = 0.002 for CABG versus MT]. We also observed higher mortality rates in the MT group (28.6%) compared with PCI (24.1%) and CABG (19.0%) groups (P = 0.015) among mild CKD subjects (adjusted HR = 0.44, 95% CI 0.25-0.76; P = 0.003 for CABG versus MT; adjusted HR = 0.56, 95% CI 0.07-4.28; P = 0.58 for PCI versus MT). Results were similar with moderate CKD group but did not achieve significance. Conclusions. Coronary interventional therapy, both PCI and CABG, is associated with lower rates of events compared with MT in mild CKD patients >10 years of follow-up. More study is needed to confirm these benefits in moderate CKD.
conferenceObject Long-Term Analysis of Ventricular Function in Patients With Stable Coronary Disease Underwent On-Pump or Off-Pump Coronary Artery Bypass Graft in Mass III(2018) SILVA, Rafael R.; HUEB, Whady; LIMA, Eduardo G.; MARTINS, Eduardo B.; V, Daniel Batista; LINHARES FILHO, Jaime P.; REZENDE, Paulo C.; GARZILLO, Cibele L.; RAMIRES, Jose A.; KALIL FILHO, RobertoconferenceObject Late Gadolinium Enhancement After Myocardial Revascularization is an Independent Predictor of Mortality Long-Term Follow-Up of Mass-v Study(2018) LINHARES FILHO, Jaime P.; HUEB, Whady; LIMA, Eduardo G.; V, Daniel Batista; REZENDE, Paulo C.; MARTINS, Eduardo B.; GARZILLO, Cibele L.; RIBAS, Fernando F.; DALLAZEN, Anderson R.; AZEVEDO, Diogo F.; VILLA, Alexandre V.; NOMURA, Cesar H.; RAMIRES, Jose A.; KALIL FILHO, Roberto- MYOCARDIAL INJURY ASSESSED BY T1 MAPPING AFTER ON-PUMP AND OFF-PUMP CORONARY ARTERY BYPASS GRAFTING: A PRE-SPECIFIED ANALYSIS OF MASS V TRIAL(2019) DALLAZEN, Anderson Roberto; BOROS, Gustavo Andre Boeing; RIBAS, Fernado Faglioni; NOMURA, Cesar; ROCHITTE, Carlos; MORAIS, Thamara; LIMA, Eduardo; MARTINS, Eduardo; REZENDE, Paulo; HUEB, Whady; RAMIRES, Jose; KALIL FILHO, Roberto
conferenceObject Impact of Glycated Hemoglobin in Diabetic Patients With Coronary Artery Disease Undergoing Surgery, Angioplasty or Clinical Treatment in a Very Long-Term Follow-Up(2018) V, Daniel Batista; HUEB, Whady; LINHARES FILHO, Jaime P.; RIBAS, Fernando F.; SILVA, Rafael R.; LIMA, Eduardo G.; DALLAZEN, Anderson R.; GARCIA, Rosa M.; REZENDE, Paulo C.; MARTINS, Eduardo B.; GARZILLO, Cibele L.; AZEVEDO, Diogo F.; SILVA, Expedito E.; RAMIRES, Jose A.; KALIL FILHO, Roberto- IMPACT OF CHRONIC KIDNEY DISEASE AMONG DIABETIC PATIENTS WITH STABLE CORONARY DISEASE UNDERGOING SURGERY, ANGIOPLASTY OR MEDICAL TREATMENT IN A 10 YEAR FOLLOW-UP(2018) BATISTA, Daniel Valente; HUEB, Whady; LINHARES FILHO, Jaime; LIMA, Eduardo; REZENDE, Paulo; AZEVEDO, Diogo; MARTINS, Eduardo; HUEB, Alexandre; SILVA, Expedito; RAMIRES, Jose; KALIL FILHO, Roberto