THAIS MAUAD
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Patologia, Faculdade de Medicina - Docente
LIM/26 - Laboratório de Pesquisa em Cirurgia Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/05 - Laboratório de Poluição Atmosférica Experimental, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/26 - Laboratório de Pesquisa em Cirurgia Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/05 - Laboratório de Poluição Atmosférica Experimental, Hospital das Clínicas, Faculdade de Medicina - Líder
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
- Urban forests, air quality and health: a systematic review(2019) ARANTES, B. L.; MAUAD, T.; SILVA FILHO, D. F.Cities are complex systems where many factors interconnect, therefore multidisciplinary research is crucial to understand their functional capacity and to improve the quality of life that these spaces offer. This research provides a decade of scientific literature review (2006 to 2016) about urban forest, air quality and health. This review aims to increase the discussion of the importance of multidisciplinary research in urban studies. In total we found 236 papers, from which 50 were selected for the systematic analyses. The number of multidisciplinary research papers is scarce in general, however, it has been growing in recent years. Most studies are found in the United States and China, a few in Latin America. but no studies have been reported in Africa. Few studies approached the three themes aforementioned simultaneously. which highlights the importance of strengthening a multidisciplinary approach for international urban forest research, creating results that allow integration of urban forest environments.
- An emerging class of air pollutants: Potential effects of microplastics to respiratory human health?(2020) AMATO-LOURENCO, Luis Fernando; GALVAO, Luciana dos Santos; WEGER, Letty A. de; HIEMSTRA, Pieter S.; VIJVER, Martina G.; MAUAD, ThaisIt is increasingly recognized that the ubiquity of convenient single-use plastic has resulted in a global plastic pollution challenge, with substantial environmental and health consequences. Physical, chemical, and biological processes result in plastic weathering, with eventual formation of debris in the micro to nano size range. There is an increasing awareness that plastic fragments are dispersed in the air and can be inhaled by humans, which may cause adverse effects on the respiratory system and on other systems. Urban environments are often characterized by high concentrations of fine airborne dust from various sources. To date, however, there is limited information on the distribution, shape, and size of microplastics in the air in urban and other environments. In this article, we review and discuss our current understanding of the exposure characteristics of airborne plastic debris in urbanized areas, focusing on concentration, size, morphology, presence of additives and distributions of different polymers. The natural and extend data are compiled and compared to laboratory-based analyses to further our understanding of the potential adverse effects of inhaled plastic particles on human health.
- The extracellular matrix - the under-recognized element in lung disease?(2016) BURGESS, Janette K.; MAUAD, Thais; TJIN, Gavin; KARLSSON, Jenny C.; WESTERGREN-THORSSON, GunillaThe lung is composed of airways and lung parenchyma, and the extracellular matrix (ECM) contains the main building blocks of both components. The ECM provides physical support and stability to the lung, and as such it has in the past been regarded as an inert structure. More recent research has provided novel insights revealing that the ECM is also a bioactive environment that orchestrates the cellular responses in its environs. Changes in the ECM in the airway or parenchymal tissues are now recognized in the pathological profiles of many respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF). Only recently have we begun to investigate whether these ECM changes result from the disease process, or whether they constitute a driving factor that orchestrates the pathological outcomes. This review summarizes our current knowledge of the alterations in the ECM in asthma, COPD, and IPF, and the contributions of these alterations to the pathologies. Emerging data suggest that alterations in the composition, folding or rigidity of ECM proteins may alter the functional responses of cells within their environs, and in so doing change the pathological outcomes. These characteristics highlight potential avenues for targeting lung pathologies in the future. This may ultimately contribute to a better understanding of chronic lung diseases, and novel approaches for finding therapeutic solutions. (c) 2016 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
- Pulmonary interstitial emphysema in fatal asthma: case report and histopathological review(2018) MAUAD, Thais; NASCIMENTO, Felipe B. P. do; DOLHNIKOFF, Marisa; PICKA, Milena C. M.; SALDIVA, Paulo H. N.Background: Mortality related to asthma has decreased worldwide since the introduction of inhaled corticosteroid therapy in the past decades. However, there are still some asthma fatalities identified mainly in populations with less access to regular treatment. Pulmonary interstitial emphysema due to alveolar rupture has been rarely described as a complication of an acute severe asthma attack, and its identification in pathological analysis can be difficult. Previous studies reported the association of pulmonary interstitial emphysema and bronchial ductal gland ectasia in asthma. Case presentation: We present the case of a 42-year-old man that died due to a fatal asthma attack. Postmortem computed tomography revealed the unusual finding of acute Pulmonary Interstitial Emphysema, confirmed by pathological analysis. We reviewed 28 cases of fatal asthma tissue and identified the presence of pulmonary interstitial emphysema in 10% of the cases. Conclusions: Postmortem computed tomography is a useful complimentary diagnostic tool for autopsies. Pulmonary Interstitial Emphysema in acute exacerbations of asthma seems to be more frequent than reported. Alveolar hyperdistension and bronchial duct gland ectasia causing tissue rupture are possible mechanisms involved in the formation of Pulmonary Interstitial Emphysema. The clinical impact of Pulmonary Interstitial Emphysema in asthma is unknown.
- COVID-19-Associated cardiac pathology at the postmortem evaluation: a collaborative systematic review(2022) ALMAMLOUK, Raghed; KASHOUR, Tarek; OBEIDAT, Sawsan; BOIS, Melanie C.; MALESZEWSKI, Joseph J.; OMRANI, Osama A.; TLEYJEH, Rana; BERBARI, Elie; CHAKHACHIRO, Zaher; ZEIN-SABATTO, Bassel; GERBERI, Dana; TLEYJEH, Imad M.; MONDOLFI, Alberto E. Paniz; V, Aloke Finn; DUARTE-NETO, Amaro Nunes; V, Amy Rapkiewicz; FRUSTACI, Andrea; KERESZTESI, Arthur-Atilla; HANLEY, Brian; MAERKL, Bruno; LARDI, Christelle; BRYCE, Clare; LINDNER, Diana; AGUIAR, Diego; WESTERMANN, Dirk; STROBERG, Edana; DUVAL, Eric J.; YOUD, Esther; BULFAMANTE, Gaetano Pietro; SALMON, Isabelle; AUER, Johann; HIRSCHBUEHL, Klaus; ABSIL, Lara; BARTON, Lisa M.; SILVA, Luiz Fernando Ferraz da; MOORE, Luiza; DOLHNIKOFF, Marisa; LAMMENS, Martin; OSBORN, Michael; REMMELINK, Myriam; SALDIVA, Paulo Hilario Nascimento; JORENS, Philippe G.; CRAVER, Randall; MONTEIRO, Renata Aparecida de Almeida; SCENDONI, Roberto; MUKHOPADHYAY, Sanjay; SUZUKI, Tadaki; MAUAD, Thais; FRACASSO, Tony; GRIMES, ZacharyBackground: Many postmortem studies address the cardiovascular effects of COVID-19 and provide valuable information, but are limited by their small sample size. Objectives: The aim of this systematic review is to better understand the various aspects of the cardio-vascular complications of COVID-19 by pooling data from a large number of autopsy studies. Data sources: We searched the online databases Ovid EBM Reviews, Ovid Embase, Ovid Medline, Scopus, and Web of Science for concepts of autopsy or histopathology combined with COVID-19, published be-tween database inception and February 2021. We also searched for unpublished manuscripts using the medRxiv services operated by Cold Spring Harbor Laboratory. Study eligibility criteria: Articles were considered eligible for inclusion if they reported human post-mortem cardiovascular findings among individuals with a confirmed SARS coronavirus type 2 (CoV-2) infection. Participants: Confirmed COVID-19 patients with post-mortem cardiovascular findings. Interventions: None. Methods: Studies were individually assessed for risk of selection, detection, and reporting biases. The median prevalence of different autopsy findings with associated interquartile ranges (IQRs). Results: This review cohort contained 50 studies including 548 hearts. The median age of the deceased was 69 years. The most prevalent acute cardiovascular findings were myocardial necrosis (median: 100.0%; IQR, 20%-10 0%; number of studies = 9; number of patients = 64) and myocardial oedema (median: 55.5%; IQR, 19.5%-92.5%; number of studies = 4; number of patients = 46). The median re-ported prevalence of extensive, focal active, and multifocal myocarditis were all 0.0%. The most prevalent chronic changes were myocyte hypertrophy (median: 69.0%; IQR, 46.8%-92.1%) and fibrosis (median: 35.0%; IQR, 35.0%-90.5%). SARS-CoV-2 was detected in the myocardium with median prevalence of 60.8% (IQR 40.4-95.6%). Conclusions: Our systematic review confirmed the high prevalence of acute and chronic cardiac pathologies in COVID-19 and SARS-CoV-2 cardiac tropism, as well as the low prevalence of myocarditis in COVID-19.
- Fragrances as a trigger of immune responses in different environments(2024) MACCHIONE, M.; YOSHIZAKI, K.; FRIAS, D. P.; MAIER, K.; SMELAN, J.; PRADO, C. M.; MAUAD, T.Fragrances can cause allergic skin reactions, expressed as allergic contact dermatitis and reactions in the respiratory tract that range from acute temporary upper airway irritation to obstructive lung disease. These adverse health effects may result from the stimulation of a specific (adaptive) immune response. Th1 cells, which essentially produce interleukin-2 (IL-2) and interferon-gamma (IFN-gamma), play a key role in allergic contact dermatitis and also on allergic sensitization to common allergens (e.g., nickel and fragrance). It has been shown that fragrance allergy leads to Th2/Th22 production of IL-4, IL-5 and IL-13, controlling the development of IgE and mediating hypersensitivity reactions in the lung, such as asthma. Cytokines released during immune response modulate the expression of cytochrome P450 (CYPs) proteins, which can result in alterations of the pharmacological effects of substances in inflammatory diseases. The mechanisms linking environment and immunity are still not completely understood but it is known that aryl hydrocarbon receptor (AhR) is a sensor with conserved ligand-activated transcription factor, highly expressed in cells that controls complex transcriptional programs which are ligand and cell type specific, with CYPs as targeted genes. This review focuses on these important aspects of immune responses of the skin and respiratory tract cells, describing some in vitro models applied to evaluate the mechanisms involved in fragrance-induced allergy.