FILOMENA MARINO CARVALHO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Patologia, Faculdade de Medicina - Docente
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/14 - Laboratório de Investigação em Patologia Hepática, Hospital das Clínicas, Faculdade de Medicina
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/14 - Laboratório de Investigação em Patologia Hepática, Hospital das Clínicas, Faculdade de Medicina
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- Discriminating between virilizing ovary tumors and ovary hyperthecosis in postmenopausal women: clinical data, hormonal profiles and image studies(2017) YANCE, V. R. V.; MARCONDES, J. A. M.; ROCHA, M. P.; BARCELLOS, C. R. G.; DANTAS, W. S.; AVILA, A. F. A.; BARONI, R. H.; CARVALHO, F. M.; HAYASHIDA, S. A. Y.; MENDONCA, B. B.; DOMENICE, S.Background: The presence of virilizing signs associated with high serum androgen levels in postmenopausal women is rare. Virilizing ovarian tumors (VOTs) and ovarian stromal hyperthecosis (OH) are the most common etiologies in virilized postmenopausal women. The differential diagnosis between these two conditions is often difficult. Objective: To evaluate the contribution of clinical features, hormonal profiles and radiological studies to the differential diagnosis of VOT and OH. Design: A retrospective study. Setting: A tertiary center. Main outcome measures: Clinical data, hormonal status (T, E2, LH and FSH), pelvic images (transvaginal sonography and MRI) and anatomopathology were reviewed. Patients: Thirty-four postmenopausal women with a diagnosis of VOT (13 women) and OH (21 women) were evaluated retrospectively. Results: Clinical signs of hyperandrogenism were more prevalent in the VOT group than the OH group. Although the VOT group showed higher T and E2 levels and lower gonadotropin levels than the OH group, a great overlap occurred among the hormone levels. A pelvic MRI provided an accurate differentiation of these two conditions. Conclusion: In this group of patients, the main features contributing to the differential diagnosis of VOT and OH were serum levels of testosterone and gonadotropins and the presence of an ovarian nodule identified on the MRI. Although the association of clinical, hormonal and radiological features contributes to the differential diagnosis of these two conditions, histopathological analysis remains the gold standard for the diagnosis of ovarian hyperandrogenism in postmenopausal women.
- Expression of PGR, HBEGF, ITGAV, ITGB3 and SPP1 genes in eutopic endometrium of infertile women with endometriosis during the implantation window: A pilot study(2017) BROI, M. G. Da; ROCHA JUNIOR, C. V.; MEOLA, J.; MARTINS, W. P.; CARVALHO, F. M.; FERRIANI, R. A.; NAVARRO, P. A.Objective: Alterations in endometrial receptivity may be involved in the etiopathogenesis of endometriosis-related infertility. The literature has suggested that patients with endometriosis present progestin resistance, which could affect embryo implantation. We question the presence of alterations in the expression of the progesterone receptor gene (PGR) and the genes related to endometrium embryo interaction regulated by progesterone. This pilot study compared the expression of PGR, HBEGF, ITGAV, ITGB3, and SPP1 genes in eutopic endometrium during the implantation window (IW) in infertile women with endometriosis with that observed in the endometrium of fertile and infertile controls. Methods: In this prospective case-control study, endometrial biopsies were performed during the IW in patients aged between 18 and 45 years old, with regular cycles and without endocrine/systemic dysfunctions, divided into endometriosis (END), infertile control (IC) and fertile control (FC) groups. Total RNA extraction, cDNA synthesis, and gene expression analysis by Real-Time PCR were performed. We assessed the size of the difference that our series was powered to detect. Results: From the 687 patients who underwent diagnostic videolaparoscopy or tubal ligation at the University Hospital, 130 were eligible. Of these, 32 had endometrial samples collected, with 17 confirmed in the IW. Fifteen samples (5 END, 5 IC and 5 FC) were analyzed. There was no significant difference in the expression of any studied gene. Our sample size allowed us to identify or discard large differences (two standard deviations) among the groups. Conclusion: Endometriosis doesn’t cause large changes in the endometrial expression of PGR, HBEGF, ITGAV, ITGB3 and SPP1 during the IW. © 2017, Sociedade Brasileira de Reproducao Assistida. All rights reserved.
conferenceObject INFLUENCE OF BODY MASS INDEX ON CLINICOPATHOLOGICAL PRESENTATION OF ENDOMETRIAL CARCINOMAS(2013) CARVALHO, J. P.; ANTON, C.; ARAUJO, M. P.; CARVALHO, F. M.conferenceObject CLINICOPATHOLOGICAL FEATURES OF ENDOMETRIAL CARCINOMA IN YOUNG AND OLD WOMEN(2013) ANTON, C.; CARVALHO, F. M.; CARVALHO, J. P. M.; FAVERO, G. M.; CARVALHO, J. P.- Ovarian yolk sac tumor coexisting with epithelial ovarian cancer: An aggressive rare entity(2017) TARANTO, P.; CARVALHO, F. M.; ROITHMANN, S.; MALUF, F. C.Yolk sac tumor (YST) is the second most common subtype of ovarian germ cell tumors. It usually occurs in the second and third decades of life and is rare in postmenopausal women. In postmenopausal women, YST is commonly an aggressive tumor and can present as a pure germ cell component or as a mixed component with other germ cell or epithelial components. The recognition of this histological subtype is important not only for differential diagnosis but also for determining prognosis and treatment decisions. In this case report, we describe a 61-year-old woman with YST coexisting with epithelial carcinoma focusing on the efficacy of systemic therapies. © 2017 The Authors
conferenceObject LYMPHOVASCULAR SPACE INVASION IS HIGHLY ASSOCIATED WITH LYMPH NODE METASTASIS IN ENDOMETRIAL CANCER(2013) CARVALHO, F. M.; ANTON, C.; SADALLA, J. C.; AGUIAR, F. N.; CARVALHO, J. P.conferenceObject Puberty in Patients with Ovotesticular DSD: Evaluation of 20 Patients(2019) MELARDI, J. W.; CUNHA, D. F. S.; CESPEDES, W. C. J.; CARVALHO, F. M.; COMINATO, L.; MENEZES FILHO, H. C.; MANNA, T. D.; FRANCO, R. R.; SEMER, B.; STEINMETZ, L.; DAMIANI, D.- CLINICOPATHOLOGICAL FEATURES ASSOCIATED WITH IMMUNOHISTOCHEMISTRY LOSS OF MISMATCH REPAIR PROTEIN MLH1 IN ENDOMETRIOID ENDOMETRIAL CARCINOMA(2019) FREITAS, D. de; AGUIAR, F. N.; ANTON, C.; BACCHI, C. E.; CARVALHO, J. P.; CARVALHO, F. M.
- 46,XY differences of sex development (DSD) due to 17β-hydroxysteroid dehydrogenase type 3 deficiency(2023) GOMES, N. L.; COSTA, E. M. F.; INACIO, M.; MARTIN, R. M.; NISHI, M. Y.; CARVALHO, F. M.; SIRCILLI, M. H. P.; TIBOR, F. D.; DOMENICE, S.; MENDONCA, B. B.In this chapter, we revise the epidemiological, clinical, hormonal, genetical findings and also the long-term outcomes of 46,XY individuals with 17β-HSD3 deficiency based on the review of previously reported cases and also our own cases. © 2023 Elsevier Inc. All rights reserved.
conferenceObject COMPARISON OF CLINICOPATHOLOGICAL CHARACTERISTICS BETWEEN GRADE 3 ENDOMETRIOID AND SEROUS/CLEAR CELLS ENDOMETRIAL ADENOCARCINOMA(2013) CARVALHO, F. M.; ANTON, C.; SILVA, A. Silva e; CARVALHO, J. P. M.; AGUIAR, F. N.; CARVALHO, J. P.