LUCIANA SACILOTTO FERNANDES
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
5 resultados
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- 2020 APHRS/HRS expert consensus statement on the investigation of decedents with sudden unexplained death and patients with sudden cardiac arrest, and of their families(2021) STILES, Martin K.; WILDE, Arthur A. M.; ABRAMS, Dominic J.; ACKERMAN, Michael J.; ALBERT, Christine M.; BEHR, Elijah R.; CHUGH, Sumeet S.; CORNEL, Martina C.; GARDNER, Karen; INGLES, Jodie; JAMES, Cynthia A.; JUANG, Jyh-Ming Jimmy; KAAB, Stefan; KAUFMAN, Elizabeth S.; KRAHN, Andrew D.; LUBITZ, Steven A.; MACLEOD, Heather; MORILLO, Carlos A.; NADEMANEE, Koonlawee; PROBST, Vincent; V, Elizabeth Saarel; SACILOTTO, Luciana; SEMSARIAN, Christopher; SHEPPARD, Mary N.; SHIMIZU, Wataru; SKINNER, Jonathan R.; TFELT-HANSEN, Jacob; WANG, Dao WuThis international multidisciplinary document intends to provide clinicians with evidence-based practical patient-centered recommendations for evaluating patients and decedents with (aborted) sudden cardiac arrest and their families. The document includes a framework for the investigation of the family allowing steps to be taken, should an inherited condition be found, to minimize further events in affected relatives. Integral to the process is counseling of the patients and families, not only because of the emotionally charged subject, but because finding (or not finding) the cause of the arrest may influence management of family members. The formation of multidisciplinary teams is essential to provide a complete service to the patients and their families, and the varied expertise of the writing committee was formulated to reflect this need. The document sections were divided up and drafted by the writing committee members according to their expertise. The recommendations represent the consensus opinion of the entire writing committee, graded by Gass of Recommendation and Level of Evidence. The recommendations were opened for public comment and reviewed by the relevant scientific and clinical document committees of the Asia Pacific Heart Rhythm Society (APHRS) and the Heart Rhythm Society (HRS); the document underwent external review and endorsement by the partner and collaborating societies. While the recommendations are for optimal care, it is recognized that not all resources will be available to all clinicians. Nevertheless, this document articulates the evaluation that the clinician should aspire to provide for patients with sudden cardiac arrest, decedents with sudden unexplained death, and their families.
- 2020 APHRS/HRS expert consensus statement on the investigation of decedents with sudden unexplained death and patients with sudden cardiac arrest, and of their families(2021) STILES, Martin K.; WILDE, Arthur A. M.; ABRAMS, Dominic J.; ACKERMAN, Michael J.; ALBERT, Christine M.; BEHR, Elijah R.; CHUGH, Sumeet S.; CORNEL, Martina C.; GARDNER, Karen; INGLES, Jodie; JAMES, Cynthia A.; JUANG, Jyh-Ming Jimmy; KAAB, Stefan; KAUFMAN, Elizabeth S.; KRAHN, Andrew D.; LUBITZ, Steven A.; MACLEOD, Heather; MORILLO, Carlos A.; NADEMANEE, Koonlawee; PROBST, Vincent; SAAREL, Elizabeth V.; SACILOTTO, Luciana; SEMSARIAN, Christopher; SHEPPARD, Mary N.; SHIMIZU, Wataru; SKINNER, Jonathan R.; TFELT-HANSEN, Jacob; WANG, Dao WuThis international multidisciplinary document intends to provide clinicians with evidence-based practical patient-centered recommendations for evaluating patients and decedents with (aborted) sudden cardiac arrest and their families. The document includes a framework for the investigation of the family allowing steps to be taken, should an inherited condition be found, to minimize further events in affected relatives. Integral to the process is counseling of the patients and families, not only because of the emotionally charged subject, but because finding (or not finding) the cause of the arrest may influence management of family members. The formation of multidisciplinary teams is essential to provide a complete service to the patients and their families, and the varied expertise of the writing committee was formulated to reflect this need. The document sections were divided up and drafted by the writing committee members according to their expertise. The recommendations represent the consensus opinion of the entire writing committee, graded by Class of Recommendation and Level of Evidence. The recommendations were opened for public comment and reviewed by the relevant scientific and clinical document committees of the Asia Pacific Heart Rhythm Society (APHRS) and the Heart Rhythm Society (HRS); the document underwent external review and endorsement by the partner and collaborating societies. While the recommendations are for optimal care, it is recognized that not all resources will be available to all clinicians. Nevertheless, this document articulates the evaluation that the clinician should aspire to provide for patients with sudden cardiac arrest, decedents with sudden unexplained death, and their families.
- European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) Expert Consensus Statement on the state of genetic testing for cardiac diseases(2022) WILDE, Arthur A. M.; SEMSARIAN, Christopher; MARQUEZ, Manlio F.; SHAMLOO, Alireza Sepehri; ACKERMAN, Michael J.; ASHLEY, Euan A.; EDUARDO, Back Sternick; BARAJAS-MARTINEZ, Hector; BEHR, Elijah R.; BEZZINA, Connie R.; BRECKPOT, Jeroen; CHARRON, Philippe; CHOCKALINGAM, Priya; CROTTI, Lia; GOLLOB, Michael H.; LUBITZ, Steven; MAKITA, Naomasa; OHNO, Seiko; ORTIZ-GENGA, Martin; SACILOTTO, Luciana; SCHULZE-BAHR, Eric; SHIMIZU, Wataru; SOTOODEHNIA, Nona; TADROS, Rafik; WARE, James S.; WINLAW, David S.; KAUFMAN, Elizabeth S.; AIBA, Takeshi; BOLLMANN, Andreas; CHOI, Jong-Il; DALAL, Aarti; DARRIEUX, Francisco; GIUDICESSI, John; GUERCHICOFF, Mariana; HONG, Kui; KRAHN, Andrew D.; INTYRE, Ciorsti Mac; MACKALL, Judith A.; MONT, Lluis; NAPOLITANO, Carlo; JUAN, Pablo Ochoa; PEICHL, Petr; PEREIRA, Alexandre C.; SCHWARTZ, Peter J.; SKINNER, Jon; STELLBRINK, Christoph; TFELT-HANSEN, Jacob; DENEKE, Thomas
- European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) Expert Consensus Statement on the State of Genetic Testing for Cardiac Diseases(2022) WILDE, Arthur A. M.; SEMSARIAN, Christopher; MARQUEZ, Manlio F.; SHAMLOO, Alireza Sepehri; ACKERMAN, Michael J.; ASHLEY, Euan A.; STERNICK, Eduardo Back; BARAJAS-MARTINEZ, Hector; BEHR, Elijah R.; BEZZINA, Connie R.; BRECKPOT, Jeroen; CHARRON, Philippe; CHOCKALINGAM, Priya; CROTTI, Lia; GOLLOB, Michael H.; LUBITZ, Steven; MAKITA, Naomasa; OHNO, Seiko; ORTIZ-GENGA, Martin; SACILOTTO, Luciana; SCHULZE-BAHR, Eric; SHIMIZU, Wataru; SOTOODEHNIA, Nona; TADROS, Rafik; WARE, James S.; WINLAW, David S.; KAUFMAN, Elizabeth S.; AIBA, Takeshi; BOLLMANN, Andreas; CHOI, Jong-Il; DALAL, Aarti; DARRIEUX, Francisco; GIUDICESSI, John; GUERCHICOFF, Mariana; HONG, Kui; KRAHN, Andrew D.; MACINTYRE, Ciorsti; MACKALL, Judith A.; MONT, Lluis; NAPOLITANO, Carlo; OCHOA, Juan Pablo; PEICHL, Petr; PEREIRA, Alexandre C.; SCHWARTZ, Peter J.; SKINNER, Jon; STELLBRINK, Christoph; TFELT-HANSEN, Jacob; DENEKE, Thomas
- A Primary Prevention Clinical Risk Score Model for Patients With Brugada Syndrome (BRUGADA-RISK)(2021) HONARBAKHSH, Shohreh; PROVIDENCIA, Rui; GARCIA-HERNANDEZ, Jorge; MARTIN, Claire A.; HUNTER, Ross J.; LIM, Wei Y.; KIRKBY, Claire; GRAHAM, Adam J.; SHARIFZADEHGAN, Ardalan; WALDMANN, Victor; MARIJON, Eloi; MUNOZ-ESPARZA, Carmen; LACUNZA, Javier; GIMENO-BLANES, Juan Ramon; ANKOU, Benedicte; CHEVALIER, Philippe; ANTONIO, Natalia; ELVAS, Luis; CASTELLETTI, Silvia; CROTTI, Lia; SCHWARTZ, Peter; SCANAVACCA, Mauricio; DARRIEUX, Francisco; SACILOTTO, Luciana; MUELLER-LEISSE, Johanna; VELTMANN, Christian; VICENTINI, Alessandro; DEMARCHI, Andrea; CORTEZ-DIAS, Nuno; ANTONIO, Pedro Silverio; SOUSA, Joao de; ADRAGAO, Pedro; CAVACO, Diogo; COSTA, Francisco Morosco; KHOUEIRY, Ziad; BOVEDA, Serge; SOUSA, Mario Joao; JEBBERI, Zeynab; HECK, Patrick; MEHTA, Sarju; CONTE, Giulio; OZKARTAL, Tardu; AURICCHIO, Angelo; LOWE, Martin D.; SCHILLING, Richard J.; PRIETO-MERINO, David; LAMBIASE, Pier D.OBJECTIVES The goal of this study was to develop a risk score model for patients with Brugada syndrome (BrS). BACKGROUND Risk stratification in BrS is a significant challenge due to the low event rates and conflicting evidence. METHODS A multicenter international cohort of patients with BrS and no previous cardiac arrest was used to evaluate the role of 16 proposed clinical or electrocardiogram (ECG) markers in predicting ventricular arrhythmias (VAs)/sudden cardiac death (SCD) during follow-up. Predictive markers were incorporated into a risk score model, and this model was validated by using out-of-sample cross-validation. RESULTS A total of 1,110 patients with BrS from 16 centers in 8 countries were included (mean age 51.8 +/- 13.6 years; 71.8% male). Median follow-up was 5.33 years; 114 patients had VA/SCD (10.3%) with an annual event rate of 1.5%. Of the 16 proposed risk factors, probable arrhythmia-related syncope (hazard ratio [HR]: 3.71; p < 0.001), spontaneous type 1 ECG (HR: 3.80; p < 0.001), early repolarization (HR: 3.42; p < 0.001), and a type 1 Brugada ECG pattern in peripheral leads (HR: 2.33; p < 0.001) were associated with a higher risk of VA/SCD. A risk score model incorporating these factors revealed a sensitivity of 71.2% (95% confidence interval: 61.5% to 84.6%) and a specificity of 80.2% (95% confidence interval: 75.7% to 82.3%) in predicting VA/SCD at 5 years. Calibration plots showed a mean prediction error of 1.2%. The model was effectively validated by using out-of-sample cross-validation according to country. CONCLUSIONS This multicenter study identified 4 risk factors for VA/SCD in a primary prevention BrS population. A risk score model was generated to quantify risk of VA/SCD in BrS and inform implantable cardioverter-defibrillator prescription. (C) 2021 The Authors.