CRISTIANO TEIXEIRA MOSTARDA
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- Autonomic changes in young smokers: acute effects of inspiratory exercise(2013) RODRIGUES, Fernando; ARAUJO, Amanda Aparecida; MOSTARDA, Cristiano Teixeira; FERREIRA, Janaina; SILVA, Michelle Cristina de Barros; NASCIMENTO, Ademir Manoel; LIRA, Fabio Santos; ANGELIS, Katia De; IRIGOYEN, Maria Claudia; RODRIGUES, BrunoOne of the most important consequences of smoking is the development of cardiovascular diseases. However, little is known about the early consequences of smoking and the acute effects of a single inspiratory muscle exercise session (IME). We evaluated the acute effects of an IME on cardiac parameters of young smokers. Twelve nonsmokers (C) and fifteen smokers [S; 2.08 (1.0-3.2) pack-years] underwent an acute IME. We evaluated blood pressure (BP) and lactate, and we recorded RR interval for posterior analysis of heart rate variability (HRV), before and after IME. At baseline, systolic BP and HRV parameters in time and frequency domains were changed in S group in comparison with the C. Following IME, S group reduced systolic BP (-8 %), low frequency band (LF) (-21.4 %), LF/high frequency (HF) (-57 %), as well as increased RR variance (+105 %) and HF band. Our findings indicate that a single session of inspiratory muscle exercise was able to both reduce systolic BP and improve parasympathetic and sympathetic modulations in young smokers. The results of the current study highlight the importance of furthering research on this area to better elucidate the acute and chronic effects of inspiratory muscle training on early cardiovascular and pulmonary changes of cigarette smoking.
- Interval and continuous aerobic exercise training similarly increase cardiac function and autonomic modulation in infarcted mice(2017) ABAD, Cesar Cavinato Cal; NASCIMENTO, Ademir Manuel do; SANTOS, Leandro Eziquiel dos; FIGUEROA, Diego; RAMONA, Pamella; SARTORI, Michele; SCAPINI, Katie B.; ALBUQUERQUE, Oscar; MORAES-SILVA, Ivana Cinthya; COELHO-JUNIOR, Hello Jose; RODRIGUES, Bruno; MOSTARDA, Cristiano Teixeira; ANGELIS, Katia De; IRIGOYEN, Maria ClaudiaThe present study aimed to compare the effects of moderate-intensity continuous and high-intensity interval exercise training (ET) on exercise tolerance, cardiac morphometry and function, hemodynamic, and cardiac autonomic modulation in myocardial infarcted mice. Wild-type mice (WT) were divided into four groups: sedentary WT (S); WT myocardium infarction sedentary (IS); WT myocardium infarction underwent to moderate-intensity continuous ET (MICT), and WT myocardium infarction underwent to high-intensity interval ET (MIIT). After 60 days of descending coronary artery ligation, moderate-intensity continuous ET consisted of running at 60% of maximum, while the high-intensity interval training consisted of eight sprints of 4 min at 80% of maximum and a 4-min recovery at 40% of maximum. Both exercises were performed 1 hr a day, 5 days a week, during 8 weeks. Results demonstrated that IS showed elevated exercise tolerance, as well as decreased hemodynamic and heart function, and autonomic control. On the other hand, both programs of ET were equally effective to increase all parameters, without further differences between the groups. In conclusion, the results of the present study showed that myocardial infarction leads to damage in both investigated strains and the two types of physical exercise attenuated the major impairments provoked by myocardial infarction in exercise tolerance, cardiac structure, cardiac function, hemodynamic and cardiac autonomic modulation.
- Ventricular and autonomic benefits of exercise training persist after detraining in infarcted rats(2013) BARBOZA, Catarina Andrade; ROCHA, Leandro Yanase; MOSTARDA, Cristiano Teixeira; FIGUEROA, Diego; CAPERUTO, Erico Chagas; ANGELIS, Katia De; IRIGOYEN, Maria Claudia; RODRIGUES, BrunoWe evaluate the effects of detraining (DT, for 1 month) on the left ventricular (LV) remodeling and function, hemodynamic and baroreflex sensitivity (BRS), as well as on mortality rate of infarcted (MI) rats after 3 months of exercise training (ET, 50-70 % of VO2max). Male Wistar rats were divided into five groups: control (C, n = 10), untrained-infarcted (UI, n = 15), trained-infarcted (TI, n = 12), untrained-infarcted plus 1 month (UI-1, n = 15) and detrained-infarcted 1 month (DI-1, n = 15). LV function was evaluated by echocardiography at the initial and final of the protocols. After following, ET and/or DT protocols, hemodynamic and BRS [by tachycardic (TR) and bradycardic (BR) responses] were assessed. TI group displayed increased VO2max in comparison with UI and DI-1 groups; however, DI-1 values remained increased compared to UI-1 group. MI area was reduced by ET and maintained after DT. Ejection fraction (TI = 60 +/- A 2 and DI-1 = 61 +/- A 2 % vs. UI = 41 +/- A 1 and UI-1 = 37 +/- A 3 %), E/A ratio (TI = 1.6 +/- A 0.1 and DI-1 = 1.9 +/- A 0.1 vs. UI = 2.9 +/- A 0.2 and UI-1 = 2.9 +/- A 0.3), TR (TI = 3.3 +/- A 0.3 and DI-1 = 3.3 +/- A 0.4 vs. UI = 1.7 +/- A 0.1 and UI-1 = 1.6 +/- A 0.1 bpm/mmHg) and BR (TI = -2.2 +/- A 0.1 and DI-1 = -2.0 +/- A 0.1 vs. UI = -1.3 +/- A 0.09 and UI-1 = -1.2 +/- A 0.09 bpm/mmHg) were improved by ET and maintained after DT in comparison with untrained rats. These changes resulted in mortality reduction in the TI (8 %) and DI-1 groups (13 %) compared with the UI (46 %) and UI-1 (53 %) groups. These findings indicate that ET is not only an effective tool in the management of cardiovascular and autonomic MI derangements, but also that these positive changes were maintained even after 1 month of DT in rats.
conferenceObject Effect of sinoaortic denervation on blood pressure and heart rate of hypertensive and control rats monitored by telemetry(2013) SANTOS, Fernando; MOREIRA, Edson Dias; MOSTARDA, Cristiano Teixeira; BARBOSA, Maikon; IRIGOYEN, Maria ClaudiaThe aim of this study was to evaluate the effects of sinoaortic denervation (SAD) on systolic blood pressure (SBP) and heart rate (HR), and possible changes in circadian cycle. Wistar (C) and spontaneously hypertensive (H) male rats were submitted to SAD and monitored for two weeks by radio transmitter implanted directly into the abdominal aorta. The acute period (48hs) after SAD procedure was characterized by SBP increase in C (39%) and in H (17%). Surprisingly, a decrease in SBP in H (12%) below baseline levels was observed nine hours after the surgery and was maintained during the next 48 hours. In contrast, SBP in C was still 14% above the baseline. C HR was unchanged, while in H it was 29% increased in the first 48 hours. After two weeks there were no significant differences in SBP and HR in C while in H a 14% reduction in SBP was observed in comparison to the baseline. In this group HR remained 3% higher. We noticed that in H group the behavior of SBP and HR did not change through circadian cycle phases. After SAD the behavior of SPB was still unchanged in H group while HR presented an increase of 6% during the active period. However, SBP behavior in the C was different during light/dark periods, both before and after SAD, with an increase in HR in active period before (8%) and after (11%) SAD. These data suggest that SAD is able to reduce SBP of H and to change the behavior of HR in hypertensive and control rats.- Interval and continuous aerobic exercise training similarly increase cardiac function and autonomic modulation in infarcted mice (vol 13, pg 257, 2017)(2017) ABAD, Cesar Cavinato Cal; NASCIMENTO, Ademir Manuel do; SOUZA, Leandro Eziquiel de; FIGUEROA, Diego; RAMONA, Pamella; SARTORI, Michele; SCAPINI, Katia B.; ALBUQUERQUE, Oscar; MORAES-SILVA, Ivana Cinthya; COELHO-JUNIOR, Helio Jose; RODRIGUES, Bruno; MOSTARDA, Cristiano Teixeira; ANGELIS, Katia De; IRIGOYEN, Maria Claudia
- EFFECT OF STRENGTH TRAINING ON CARDIOVASCULAR VARIABLES IN OVERWEIGHT ADOLESCENTS(2014) MIRANDA, Joao Marcelo de Queiroz; DIAS, Leandro da Costa; MOSTARDA, Cristiano Teixeira; ANGELIS, Katia De; FIGUEIRA JUNIOR, Aylton Jose; WICHI, Rogerio BrandaoObjective: This study aimed to evaluate the acute cardiorespiratory and autonomic responses induced by a resistive exercise session in overweight adolescents. Methods: We evaluated 17 male adolescents divided into control group (CG, n = 9) and overweight group (OWG, n = 7). All patients underwent one session of resistance exercises for different muscle groups, performed with overload of 60% of maximum strength, with an interval of 45 seconds between sets and 90 seconds between each exercise. Before, during and after the exercise session the following parameters were evaluated: heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate variability (HRV). Results: We observed similar behavior in both groups of SBP and DBP. The SBP increased during exercise while the DBP decreased. Both returned to baseline during recovery. HR increased during the workout in the two groups, but return to resting values only occurred in the OWG. The HRV indices in the time domain (VAR RR and RMSSD) behaved similarly to the exercise in both groups, but the SDNN index only returned to resting values in the OWG. HRV in the frequency domain exhibited similar behavior in both groups. Conclusions: It is suggested that the increased level of physical activity in overweight individuals can prevent autonomic changes that are associated with increased body weight and confer a protective effect on the cardiovascular system
conferenceObject Interval training program improves cardiac function and physical performance in heart failure mice(2013) ABAD, Cesar Cavinato Cal; MOSTARDA, Cristiano Teixeira; NASCIMENTO, Ademir Manuel; SANTOS, Mirailton Alves dos; SOUZA, Leandro Eziquiel; FIGUEROA, Diego M. T.; SANTOS, Fernando; SOUZA, Pamella Ramona Moraes de; ANGELIS, Katia De; IRIGOYEN, Maria ClaudiaThis study was designed to verify the effect of an eight week interval training program (IT) in systolic and diastolic functions and physical performance in heart failure mice (C57B16, n=24). The animals were divided in three groups: 1) Intact sedentary (C), 2) infarcted sedentary (MI-s); and 3) infarcted trained (MI-i). At the begining (M1) and at the end of IT (M2), time of maximal running performance (Tvmáx) was quantified. The ejection fraction (EF), shortening fraction (SF) and isovolumetric relaxation time (IVRT) were accessed by echocardiography in M2. At 60 days after coronary artery occlusion the IT was started (4min at 80% Vmáx x 4min at 40% Vmáx during 60min). The results are presented in mean and SEM. Myocardial infarction area was not different between groups in both evaluation time (M1vsM2). The EF and SF in MI-s were lower than C (44±3.7vs58±3.0% and 22±2vs31±2%, respectively; p≤0.05) but similar between MI-i and C (56±5vs58±3% and 25±3vs31±2%, respectively). The IVRT was higher (p≤0.05) in MI-s (25.6±4ms) than C (13±1ms) while similar in MI-i (15±0.8ms) and C. At the M1 both MI-s and MI-i Tvmáx decreased in comparison with C (620±16 and 644±28vs840±17s, respectively). At the M2, Tvmáx delta percent was higher in MI-i than MI-s (64±8vs15±6%, respectively; p≤0.05) and C (0.53±3%). The results suggest that IT improves cardiac function and physical performance in heart failure mice.- Previous Exercise Training Has a Beneficial Effect on Renal and Cardiovascular Function in a Model of Diabetes(2012) SILVA, Kleiton Augusto dos Santos; LUIZ, Rafael da Silva; RAMPASO, Rodolfo Rosseto; ABREU, Nayda Parisio de; MOREIRA, Edson Dias; MOSTARDA, Cristiano Teixeira; ANGELIS, Katia De; TEIXEIRA, Vicente de Paulo Castro; IRIGOYEN, Maria Claudia; SCHOR, NestorExercise training (ET) is an important intervention for chronic diseases such as diabetes mellitus (DM). However, it is not known whether previous exercise training intervention alters the physiological and medical complications of these diseases. We investigated the effects of previous ET on the progression of renal disease and cardiovascular autonomic control in rats with streptozotocin (STZ)-induced DM. Male Wistar rats were divided into five groups. All groups were followed for 15 weeks. Trained control and trained diabetic rats underwent 10 weeks of exercise training, whereas previously trained diabetic rats underwent 14 weeks of exercise training. Renal function, proteinuria, renal sympathetic nerve activity (RSNA) and the echocardiographic parameters autonomic modulation and baroreflex sensitivity (BRS) were evaluated. In the previously trained group, the urinary albumin/creatinine ratio was reduced compared with the sedentary diabetic and trained diabetic groups (p < 0.05). Additionally, RSNA was normalized in the trained diabetic and previously trained diabetic animals (p < 0.05). The ejection fraction was increased in the previously trained diabetic animals compared with the diabetic and trained diabetic groups (p < 0.05), and the myocardial performance index was improved in the previously trained diabetic group compared with the diabetic and trained diabetic groups (p < 0.05). In addition, the previously trained rats had improved heart rate variability and BRS in the tachycardic response and bradycardic response in relation to the diabetic group (p < 0.05). This study demonstrates that previous ET improves the functional damage that affects DM. Additionally, our findings suggest that the development of renal and cardiac dysfunction can be minimized by 4 weeks of ET before the induction of DM by STZ.
- Effects of catecholamines on volemic replacement with saline solution and the impact on heart rate variability in rabbits subjected to hemorrhage. A study by spectral analysis(2014) MORAES, Jose Mariano Soares de; VANE, Matheus Fachini; RODRIGUES, Denise de Fatima; MOSTARDA, Cristiano Teixeira; MORAES, Thiago Soares Mendes Moreira de; VANE, Lucas Fachini; GANEM, Eliana Marisa; CAVALCANTI, Ismar Lima; MODOLO, Norma Sueli Pinheiro; VANE, Luiz AntonioPURPOSE: To verify the effects of different catecholamines on volemic expansion and on the autonomic nervous system in rabbits that were subjected to hemorrhage. METHODS: Twenty four rabbits subjected to hemorrhage (with a 25% loss of blood volume) and were randomly divided into four experimental groups: 1) HEMO Group underwent replacement with their own blood in an equal volume; 2) SS Group underwent replacement with saline solution (SS) in a volume that corresponded to three times the removed blood volume; 3) ISP Group underwent replacement with SS and isoprenaline; 4) FNL Group underwent replacement with SS and phenylephrine. Spectral Analysis of the heart rate and heart rate variability were performed from the recorded data. Hematocrit was measured throughout the experiment. RESULTS: Replacement with SS and an alpha- or beta- agonist did not produce differences in the intravascular retention compared to replacement with SS alone. An analysis of HRV showed that the FNL group maintained the LF/HF ratio better than ISP and SS. CONCLUSIONS: No difference in vascular retention when alpha- or beta- agonists were added to SS during post-hemorrhagic recovery. The animals in the FNL group maintained the integrity of the autonomic response within normal physiological standards during hemorrhagic stress.
- Sevoflurane preconditioning during myocardial ischemia-reperfusion reduces infarct size and preserves autonomic control of circulation in rats(2016) PASQUALIN, Rubens Campana; MOSTARDA, Cristiano Teixeira; SOUZA, Leandro Ezequiel de; VANE, Matheus Fachini; SIRVENTE, Raquel; OTSUKI, Denise Aya; TORRES, Marcelo Luis Abramides; IRIGOYEN, Maria Claudia Costa; AULER, Jose Otavio CostaPURPOSE: To investigate the myocardial ischemia-reperfusion with sevoflurane anesthetic preconditioning (APC) would present beneficial effects on autonomic and cardiac function indexes after the acute phase of a myocardial ischemia-reperfusion. METHODS: Twenty Wistar rats were allocated in three groups: control (CON, n=10), myocardial infarction with sevoflurane (SEV, n=5) and infarcted without sevoflurane (INF, n=5). Myocardial ischemia (60 min) and reperfusion were performed by temporary coronary occlusion. Twenty-one days later, the systolic and diastolic function were evaluated by echocardiography; spectral analysis of the systolic arterial pressure (SAPV) and heart rate variability (HRV) were assessed. After the recording period, the infarct size (IS) was evaluated. RESULTS: The INF group presented greater cardiac dysfunction and increased sympathetic modulation of the SAPV, as well as decreased alpha index and worse vagal modulation of the HRV. The SEV group exhibited attenuation of the systolic and diastolic dysfunction and preserved vagal modulation (square root of the mean squared differences of successive R-R intervals and high frequency) of HRV, as well as a smaller IS. CONCLUSION: Sevoflurane preconditioning better preserved the cardiac function and autonomic modulation of the heart in post-acute myocardial infarction period.