CRISTIANO TEIXEIRA MOSTARDA

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    Diabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in rats
    (2014) MALFITANO, C.; BARBOZA, C. A. B.; MOSTARDA, C. M.; PALMA, R. K. P.; CONSOLIM-COLOMBO, F. M. C. C.; BELLO-KLEIN, A. B. K.; IRIGOYEN, M. C. I.; ANGELIS, K. D. A. De
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    Ventricular and autonomic benefits of exercise training in myocardial infarction persists after detraining
    (2012) BARBOZA, C. A.; ROCHA, L. Y.; DIAS, D. S.; MOSTARDA, C. T.; FIGUEROA, D. M. T.; ANGELIS, K. De; IRIGOYEN, M. C.; RODRIGUES, B.
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    Baroreflex and cardiac dysfunctions evaluated by transesophageal echocardiography, baroreflex sensitivity, autonomic control and invasive measurements in rats submitted to sinoaortic denervation
    (2012) SIRVENTE, R. A.; IRIGOYEN, M. C.; SOUZA, L.; MOSTARDA, C.; FUENTE, R. La; CANDIDO, G.; SOUZA, P.; MEDEIROS, A.; MADY, C.; SALEMI, V. M. C.
    Purpose: Sympathetic hyperactivity commonly seems to be related to cardiac dysfunction and baro and chemoreflexes impairment in hypertension. However, myocardial function has not been evaluated regarding the association of hypertension and baroreflex dysfunction using transesophageal echocardiography. Methods: Exercise test (ET), baroreflex sensitivity, cardiovascular autonomic control, transthoracic and transesophageal echocardiography using intracardiac echocardiographic catheter (AcuNav, Siemens, Mountain View, CA, USA), and invasively biventricular end-diastolic pressures (EDP) were evaluated in rats 10 weeks after sinoaortic denervation (SAD). The rats (n=32) were divided in 4 groups: 16 Wistar (W) with (n=8) or without SAD (n=8) and 16 spontaneously hypertensive rats (SHR) with (n=8) or without SAD (n=8). Results: Blood pressure (BP) and heart rate (HR) did not show any change between the groups SAD and without SAD, although, SHR showed higher BP levels in comparison to W. BP variability was increased in SHR groups compared to W. After SAD, BP variability increased in all groups compared to W (W: 15 mmHg2; *DSA: 49 mmHg2; *SHR: 60 mmHg2; *SHR-SAD:137 mmHg2, *p<0.05 vs. W). Exercise tests results showed that SHR had better functional capacity compared to SAD and SHRSAD (W: 1.16m/s; DSA: 0.9m/s; *SHR: 1.46; SHR-DSA: 1.02, *p<0.05 vs. SAD and SHRSAD). Left ventricular concentric hypertrophy, segmental systolic dysfunction and global diastolic LV dysfunction, segmental and global systolic dysfunction, and global diastolic RV dysfunction, indirect signals of pulmonary arterial hypertension were shown by echocardiography, mostly evident in SHRSAD. The RV-EDP increased in all groups compared to W(W:3±0.39mmHg, *SAD:4.7±0.52mmHg, *SHR: 6.6±1.1mmHg, *SHRSAD:7.8±0.87mmHg, *p<0.05 vs. W), and LV-EDP increased in SHR and SHRSAD groups compared to W, and in SHRSAD compared to SAD (W: 5,83±0,19 mmHg,SAD: 8.98±1.2 mmHg, *SHR: 12.51±4.73 mmHg, *#SHRSAD: 14.57±2.52mmHg, *p<0.05vs.W,#p<0.05 vs. DSA). There was a relation between invasive or noninvasive measurements of RV showing good accuracy of echocardiographic measurements. Conclusions: Our results suggest that baroreflex dysfunction impaired biventricular function. Moreover, the findings of RV dysfunction indicate that SAD may lead to increased pulmonary artery pressure, supporting a role for baroreflex dysfunction in the pathogenesis of the hypertensive cardiac disease.
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    Inspiratory loaded exercises improve cardiovascular vagal modulation and barorreflex sensitivity in subjects with hypertension
    (2013) FERREIRA, J.; MOSTARDA, C.; LAGO, P. Dal; SANTOS, F.; CONSOLIM-COLOMBO, F.; IRIGOYEN, M. C.
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    Chronic Absence of Baroreceptors Induces Left Ventricular Dysfunction and Reduced Coronary Blood Flow in Spontaneously Hypertensive Rats
    (2013) SOUZA, Pamella R.; MOREIRA, Edson D.; MOSTARDA, Cristiano; JORGE, Luciana; MONTEIRO-DE-MORAES, Wilson Max; GUIMARAES, Fabiana; OLIVEIRA, Edilamar Menezes; FLUES, Karin; SILVA, Maikon Barbosa; IRIGOYEN, Maria Claudia
    Hemodynamic and cardiac morphological variables were measured in normotensive Wistar (N), intacts hypertensive (H) and SHR submitted to sinoaortic denervation (DH) to evaluate the chronic baroreceptor dysfunction on left ventricular (LV) functions and coronary blood flow. Blood (BP) and end-diastolic pressure (PD2) were obtained by direct quantification. The coronary blood flow was measured by the infusion of colored microspheres. The ratio of left ventricular weight to body weight, natriuretic atrial peptide (ANP), alpha-skeletal actin (α-skelectal), alpha and beta myosin heavy chain (α-MHC, β-MHC) genes mRNA expressions were evaluated by real time PCR to assess ventricular hypertrophy. The results were reported as means ± SEM. DH rats did not change BP values compared to H. PD2 of DH (9.91±1.78) was higher than H group (4.30±0.53) while an inverse result regarding coronary blood flow was observed (0.94±0.15 vs 1.80±0.25, respectively). The LV adaptations in DH were higher than in H (2.98 ±0.07 vs 2.15±0.05), as well as the expression of ANP (3.35±0.19 vs 2.39 ± 0.74), β-MHC (3.36±0.18 vs 2.39 ± 0.37). The α-MHC genes expression also were decreased (0.62±0.10 vs 0.79±0.10). Therefore, the chronic absence of baroreflex control by sinoaortic denervation induces left ventricular dysfunction and reduced coronary blood flow in SHR.
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    High fructose intake induces cardiac diastolic dysfunction in rats
    (2012) ARAUJO, Iara Cristina; MOSTARDA, Cristiano; LIMA, Polyana de Souza; YAMANE, Larissa Naomi; SOUZA, Marina Soares de; FONTELES, Manasses; FIORINO, Patricia; FARAH, Vera
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    Effect of sinoaortic denervation on blood pressure and heart rate of hypertensive and control rats monitored by telemetry
    (2013) SANTOS, Fernando; MOREIRA, Edson Dias; MOSTARDA, Cristiano Teixeira; BARBOSA, Maikon; IRIGOYEN, Maria Claudia
    The aim of this study was to evaluate the effects of sinoaortic denervation (SAD) on systolic blood pressure (SBP) and heart rate (HR), and possible changes in circadian cycle. Wistar (C) and spontaneously hypertensive (H) male rats were submitted to SAD and monitored for two weeks by radio transmitter implanted directly into the abdominal aorta. The acute period (48hs) after SAD procedure was characterized by SBP increase in C (39%) and in H (17%). Surprisingly, a decrease in SBP in H (12%) below baseline levels was observed nine hours after the surgery and was maintained during the next 48 hours. In contrast, SBP in C was still 14% above the baseline. C HR was unchanged, while in H it was 29% increased in the first 48 hours. After two weeks there were no significant differences in SBP and HR in C while in H a 14% reduction in SBP was observed in comparison to the baseline. In this group HR remained 3% higher. We noticed that in H group the behavior of SBP and HR did not change through circadian cycle phases. After SAD the behavior of SPB was still unchanged in H group while HR presented an increase of 6% during the active period. However, SBP behavior in the C was different during light/dark periods, both before and after SAD, with an increase in HR in active period before (8%) and after (11%) SAD. These data suggest that SAD is able to reduce SBP of H and to change the behavior of HR in hypertensive and control rats.
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    Interval training program improves cardiac function and physical performance in heart failure mice
    (2013) ABAD, Cesar Cavinato Cal; MOSTARDA, Cristiano Teixeira; NASCIMENTO, Ademir Manuel; SANTOS, Mirailton Alves dos; SOUZA, Leandro Eziquiel; FIGUEROA, Diego M. T.; SANTOS, Fernando; SOUZA, Pamella Ramona Moraes de; ANGELIS, Katia De; IRIGOYEN, Maria Claudia
    This study was designed to verify the effect of an eight week interval training program (IT) in systolic and diastolic functions and physical performance in heart failure mice (C57B16, n=24). The animals were divided in three groups: 1) Intact sedentary (C), 2) infarcted sedentary (MI-s); and 3) infarcted trained (MI-i). At the begining (M1) and at the end of IT (M2), time of maximal running performance (Tvmáx) was quantified. The ejection fraction (EF), shortening fraction (SF) and isovolumetric relaxation time (IVRT) were accessed by echocardiography in M2. At 60 days after coronary artery occlusion the IT was started (4min at 80% Vmáx x 4min at 40% Vmáx during 60min). The results are presented in mean and SEM. Myocardial infarction area was not different between groups in both evaluation time (M1vsM2). The EF and SF in MI-s were lower than C (44±3.7vs58±3.0% and 22±2vs31±2%, respectively; p≤0.05) but similar between MI-i and C (56±5vs58±3% and 25±3vs31±2%, respectively). The IVRT was higher (p≤0.05) in MI-s (25.6±4ms) than C (13±1ms) while similar in MI-i (15±0.8ms) and C. At the M1 both MI-s and MI-i Tvmáx decreased in comparison with C (620±16 and 644±28vs840±17s, respectively). At the M2, Tvmáx delta percent was higher in MI-i than MI-s (64±8vs15±6%, respectively; p≤0.05) and C (0.53±3%). The results suggest that IT improves cardiac function and physical performance in heart failure mice.