REGIANI CARVALHO DE OLIVEIRA
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Patologia, Faculdade de Medicina
LIM/05 - Laboratório de Poluição Atmosférica Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/05 - Laboratório de Poluição Atmosférica Experimental, Hospital das Clínicas, Faculdade de Medicina
4 resultados
Resultados de Busca
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- Aerobic exercise in polluted urban environments: effects on airway defense mechanisms in young healthy amateur runners(2016) SA, Matheus Cavalcante de; NAKAGAWA, Naomi Kondo; ANDRE, Carmen Diva Saldiva de; CARVALHO-OLIVEIRA, Regiani; CARVALHO, Tamas de Santana; NICOLA, Marina Lazzari; ANDRE, Paulo Afonso de; SALDIVA, Paulo Hilario Nascimento; VAISBERG, MauroIn this study, the effects of aerobic exercise on the upper airways and their defense mechanisms were investigated in athletes. The athletes ran in two different environments: the downtown streets of the city of Sao Paulo (Street), more polluted, and an urban forest (Forest), less polluted. Thirty-eight young healthy athletes ran for 45 min d(-1) randomly during five consecutive days, with an interval of 48 h before changing environment. Clinical parameters and respiratory tract defense markers were evaluated before and after the first run on Mondays (1 d) and on Fridays (5 d). Street presented higher mean PM2.5 concentrations (65.1 +/- 39.1 mu gm(-3), p < 0.001) and lower temperature (22.0 degrees C, p = 0.010) than Forest (22.6 +/- 15.3 mu g m(-3) and 22.8 degrees C). After 1 d Street running, subjects showed an increment in heart rate (p < 0.001). At day 5, there was twice the number of athletes with impaired nasal mucociliary clearance (MCC) in the Street runners group when compared to the Forest runners group. Exhaled breath condensate pH values increased in the Forest group, with significant differences between groups in day 1 (p = 0.006) and day 5 (p < 0.001), despite the fact that both groups showed values within the normal range. After exposure to both environments, the number of cells in the nasal lavage fluid was reduced after exercise (p = 0.014), without alterations in cell type and IL-8 and IL-10 concentrations. Aerobic exercise can either maintain or acutely enhance MCC and it may help to regulate inflammatory responses in the airways. Here we show that exercise practice in polluted outdoor environment, over a 5 d period, impairs MCC. In contrast, athletes running in the less polluted environment (Forest) show higher exhaled breath condensate pH values when compared to those who exercised in a more polluted environment (Street).
- Mucociliary clearance, airway inflammation and nasal symptoms in urban motorcyclists(2014) BRANT, Tereza C. S.; YOSHIDA, Carolina T.; CARVALHO, Tomas de S.; NICOLA, Marina L.; MARTINS, Jocimar A.; BRAGA, Lays M.; OLIVEIRA, Regiani C. de; LEYTON, Vilma; ANDRE, Carmen S. de; SALDIVA, Paulo H. N.; RUBIN, Bruce K.; NAKAGAWA, Naomi K.OBJECTIVES: There is evidence that outdoor workers exposed to high levels of air pollution exhibit airway inflammation and increased airway symptoms. We hypothesized that these workers would experience increased airway symptoms and decreased nasal mucociliary clearance associated with their exposure to air pollution. METHODS: In total, 25 non-smoking commercial motorcyclists, aged 18-44 years, were included in this study. These drivers work 8-12 hours per day, 5 days per week, driving on urban streets. Nasal mucociliary clearance was measured by the saccharine transit test; airway acidification was measured by assessing the pH of exhaled breath condensate; and airway symptoms were measured by the Sino-nasal Outcome Test-20 questionnaire. To assess personal air pollution exposure, the subjects used a passive-diffusion nitrogen dioxide (NO2) concentration-monitoring system during the 14 days before each assessment. The associations between NO2 and the airway outcomes were analyzed using the Mann-Whitney test and the Chi-Square test. Clinicaltrials.gov: NCT01976039. RESULTS: Compared with clearance in healthy adult males, mucociliary clearance was decreased in 32% of the motorcyclists. Additionally, 64% of the motorcyclists had airway acidification and 92% experienced airway symptoms. The median personal NO2 exposure level was 75 mg/m(3) for these subjects and a significant association was observed between NO2 and impaired mucociliary clearance (p = 0.036). CONCLUSION: Non-smoking commercial motorcyclists exhibit increased airway symptoms and airway acidification as well as decreased nasal mucociliary clearance, all of which are significantly associated with the amount of exposure to air pollution.
- Effectiveness of the 40-Minute Handmade Manikin Program to Teach Hands-on Cardiopulmonary Resuscitation at School Communities(2021) NAKAGAWA, Naomi K.; OLIVEIRA, Katia M. G.; LOCKEY, Andrew; SEMERARO, Federico; AIKAWA, Priscila; MACCHIONE, Mariangela; CARVALHO-OLIVEIRA, Regiani; GOUVEA, Gabriela B.; BOAVENTURA, Ana Paula; I, Adalgisa Maiworm; CALDERARO, Marcelo; HAJJAR, Ludhmila A.; V, Eduardo Motta; SOUZA, Heraldo P.; ANDRE, Carmen D. S. de; SILVA, Luiz F. F.; POLASTRI, Thatiane F.; TIMERMAN, Sergio; CARMONA, Maria Jose C.; BOETTIGER, Bernd W.Bystander training in cardiopulmonary resuscitation (CPR) is crucial to improve the victims' survival and quality of life after sudden cardiac arrest. This observational study aimed to determine the success rate of 2 different programs of CPR training for children, adolescents, and adults in school communities. We assessed the development and acquisition of the following CPR skills checking local safety, assessing victim's responsiveness, calling for help, assessing victim's breathing, and performing chest compression (hands and straight arms placement on the chest, compression velocity, depth, and chest release) using a 40-minute program with handmade manikins or the 120-minute program using intermediate-fidelity manikins. There were 1,630 learners (mean age 16 years, 38% male) in the 40-minute program, and 347 learners (mean age 27 years, 32% male) in the 120-minute program. The lowest successful pass rate of learners that developed CPR skills was 89.4% in the 40-minute program and 84.5% in the 120-minute program. The chances of success increased with age in the same program (compression rate and depth). The success rate also increased with the more extended and intermediate-cost program at the same age (assessing victim's responsiveness, calling for help, and assessing the victim's respiration). In conclusion, a 40-minute and cheaper (low-cost handmade manikin) CPR program was adequate to develop and acquire the overall CPR skills for >= 89% at school communities, independently of gender. However, some individual CPR skills can be further improved with increasing age and using the longer and intermediate-cost program.
- KIDS SAVE LIVES BRAZIL: A successful pilot program to implement CPR at primary and high schools in Brazil resulting in a state law for a training CPR week(2019) NAKAGAWA, N. K.; SILVA, L. M.; CARVALHO-OLIVEIRA, R.; OLIVEIRA, K. M. G.; SANTOS, F. R. A.; CALDERARO, M.; SOUZA, H. P.; HAJJAR, L. A.; MOTTA, E. V.; TEIXEIRA, P. W. G. N.; TIMERMAN, S.; SEMERARO, F.; CARMONA, M. J. C.; BOETTIGER, B. W.