ABRAO RAPOPORT
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- Value of immunohistochemistry in the diagnosis of malignant cervical lymph nodes(2013) CALY, Decio de Natale; RAPOPORT, Abrao; CURIONI, Otavio Alberto; DEDIVITIS, Rogerio Aparecido; CERNEA, Claudio Roberto; BRANDAO, Lenine GarciaThe cervical lymph nodes are relevant due to the diversity of clinical entities. The use of immunohistochemistry is a real method to elucidate the diagnosis of adenopathy, both primary and metastatic neoplasms. Objective: To assess the value of immunohistochemistry in the diagnosis of cervical lymph nodes malignancies. Method: Retrospective study of the database histopathological specimens from 2009 to 2011. Results: Out of 32 biopsies of cervical lymph nodes, in 16 (50%) the immunohistochemistry was employed, being 68.75% (11) in hematological neoplasms and 31.25% (5) in carcinomas. It was used in all cases of lymphoma. Conclusion: The immunohistochemistry was used in 50% of the biopsies of lymph nodes under suspicion of malignancy, being 31.25% in epithelial lesions and 68.75% in lymphoproliferative lesions.
- Indications and pitfalls of immunohistochemistry in head and neck cancer(2013) CALY, Decio de Natale; VIANA, Acklei; RAPOPORT, Abrao; DEDIVITIS, Rogerio Aparecido; CURIONI, Otavio Alberto; CERNEA, Claudio Roberto; BRANDAO, Lenine GarciaImmunohistochemistry (IHC) has been employed in the differential diagnosis of tumors. Objective: To assess the use of IHC in cases of head and neck tumor. Method: This is a retrospective study of the cases included in the Cancer Registry of the institution. Results: IHC was used in 76 (11%) of 704 pathology tests. Most cases were carcinomas (85.80%), and 83.66% of them were squamous cell carcinomas. All tests were done with diagnostic purposes. The most frequently used antibodies were 34BE12 (37.18%), AE1/AE3 (35.9%), 35BH11 (28.21%), CD45 (25.64%), CD20 (24.36V, CD30 (24.36%), CK7 (23.08%) and CD3 (23.08%). Conclusions: IHC was used in 10.67% of the head and neck tumor cases submitted to pathology testing, mostly for carcinoma (5.26%). In the determination of squamous cell carcinoma, IHC accounted for 18.42% of all tumors.
- The histological rarity of thyroid cancer(2012) VIANNA, Debora Modelli; CURIONI, Otavio Alberto; FRANCA, Luciano Jose de Lemos; PAIVA, Diogenes Lopes de; POMPEU, Bernardo Fontel; DEDIVITIS, Rogerio Aparecido; RAPOPORT, AbraoThyroid cancer is the most common endocrine cancer, accounting for about 1% of all cancers. Sarcomas, lymphomas and metastases to the thyroid gland are rare and only with a handful of descriptions in the literature. Objective: To describe rare histological types of thyroid cancer found in a reference center. Methods: Medical chart review from admitted patients diagnosed with thyroid cancer in the period from 1977 to 2010. Demographic, diagnostic, therapeutic and histopathological information were collected. Results: 3,018 records of patients admitted with thyroid disease were reviewed. Among the cases diagnosed with rare tumors there was a predominance of: anaplastic carcinoma: 22 cases (0.7%), followed by 11 cases of medullary carcinoma (0.36%); 2 cases of sarcoma (0.07%), 2 cases of lymphoma (0.07%) and one case of metastatic carcinoid tumor (0.03%). There were more females diagnosed (57%) as well as Caucasians (84%). The most frequent clinical presentation was a palpable thyroid nodule. All patients with lymphoma, sarcoma and anaplastic carcinoma died. Conclusion: Sarcomas, lymphomas and thyroid metastases are uncommon and tend to worse outcomes.