DANIELA SOUZA FARIAS ITAO

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LIM/22 - Laboratório de Patolologia Cardiovascular, Hospital das Clínicas, Faculdade de Medicina

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Revista / Livro: Journal of the American Heart Association ×

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  • article 16 Citação(ões) na Scopus
    Macrophage Polarization in the Perivascular Fat Was Associated With Coronary Atherosclerosis
    (2022) FARIAS-ITAO, Daniela Souza; PASQUALUCCI, Carlos Augusto; ANDRADE, Renato Araujo de; SILVA, Luiz Fernando Ferraz da; YAHAGI-ESTEVAM, Maristella; LAGE, Silvia Helena Gelas; LEITE, Renata Elaine Paraizo; CAMPO, Alexandre Brincalepe; SUEMOTO, Claudia Kimie
    Background Inflammation of the perivascular adipose tissue (PvAT) may be related to atherosclerosis; however, the association of polarized macrophages in the pericoronary PvAT with measurements of atherosclerosis components in humans has not been fully investigated. Methods and Results Coronary arteries were dissected with surrounding PvAT. We evaluated the percentage of arterial obstruction, intima-media thickness, fibrous cap thickness, plaque components, and the number of vasa vasorum. The number of proinflammatory (M1) and anti-inflammatory (M2) macrophages in the periplaque and control PvAT were evaluated using immunohistochemistry. Regression models adjusted for sociodemographic and clinical variables were used. In 319 segments from 82 individuals, we found a correlation of the M1/M2 macrophage density ratio with an increase in arterial obstruction (P=0.02) and lipid content (P=0.01), and a decrease in smooth muscle cells (P=0.02). M1 and the ratio of M1/M2 macrophages were associated with an increased risk of thrombosis (P=0.03). In plaques with thrombosis, M1 macrophages were correlated with a decrease in fibrous cap thickness (P=0.006), an increase in lipid content (P=0.008), and the number of vasa vasorum in the adventitia layer (P=0.001). M2 macrophages were correlated with increased arterial obstruction (P=0.01), calcification (P=0.02), necrosis (P=0.03) only in plaques without thrombosis, and decrease of the number of vasa vasorum in plaques with thrombosis (P=0.003). Conclusions M1 macrophages in the periplaque PvAT were associated with a higher risk of coronary thrombosis and were correlated with histological components of plaque progression and destabilization. M2 macrophages were correlated with plaque size, calcification, necrotic content, and a decrease in the number of vasa vasorum in the adventitia layer.
  • article 29 Citação(ões) na Scopus
    B Lymphocytes and Macrophages in the Perivascular Adipose Tissue Are Associated With Coronary Atherosclerosis: An Autopsy Study
    (2019) FARIAS-ITAO, Daniela Souza; PASQUALUCCI, Carlos Augusto; NISHIZAWA, Aline; SILVA, Luiz Fernando Ferraz da; CAMPOS, Fernanda Marinho; BITTENCOURT, Marcio Sommer; SILVA, Karen Cristina Souza da; LEITE, Renata Elaine Paraizo; GRINBERG, Lea Tenenholz; FERRETTI-REBUSTINI, Renata Eloah de Lucena; JACOB-FILHO, Wilson; SUEMOTO, Claudia Kimie
    Background Macrophages and T lymphocytes in the perivascular adipose tissue (PvAT) were previously linked to coronary artery disease. However, the role of these cells and B lymphocytes in the human PvAT adjacent to unstable atherosclerotic plaques has not been investigated. Moreover, previous studies were inconclusive on whether PvAT inflammation was restricted to the surroundings of the atheroma plaque. Methods and Results Coronary arteries were freshly dissected with the surrounding PvAT. Atherosclerotic plaques were classified according to the internationally accepted anatomopathological criteria. Immune cells in the PvAT were detected using immunohistochemistry and then quantified. We used linear and logistic regressions with robust standard errors, adjusted for possible confounding factors. In 246 atherosclerotic plaques (205 stable and 41 unstable plaques) from 82 participants (mean age=69.0 +/- 14.4 years; 50% men), the percentage of arterial obstruction was positively correlated with the densities of CD68(+) macrophages (P=0.003) and CD20(+) B lymphocytes (P=0.03) in the periplaque PvAT. The number of cells was greater in the periplaque PvAT than in the distal PvAT (macrophages, P<0.001; B lymphocytes, P=0.04). In addition, the density of macrophages in the periplaque PvAT was greater in the presence of unstable plaques (P=0.03) and was also greater near unstable plaques than in the distal PvAT (P=0.001). CD3(+) T lymphocytes were not associated with percentage of obstruction and stable/unstable plaque composition. Conclusions The density of CD20(+) B lymphocytes and CD68(+) macrophages in periplaque PvAT was increased with plaque size, and the CD68(+) macrophages were greater near unstable atherosclerotic plaques than near stable lesions. This inflammation was more intense in the periplaque PvAT than in the PvAT distal to the atherosclerotic plaques.