VICTOR ZANDONA DE ANTONIO

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Autor e Coautores FMUSP-HC Normalizados: ANDERSON CARLOS WOITE SILVA ×

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  • conferenceObject
    EXERCISE AND PHARMACOLOGIC STRESS-INDUCED T-WAVE HETEROGENEITY FOR DETECTION OF CLINICALLY SIGNIFICANT CORONARY ARTERY STENOSIS
    (2018) SILVA, Anderson Carlos; ANTONIO, Victor Zandona De; SROUBEK, Jakub; GERVINO, Ernest; HO, Kalon; STOCCO, Fernando G.; NEARING, Bruce D.; VERRIER, Richard L.
  • article 6 Citação(ões) na Scopus
    Exercise and pharmacologic stress-induced interlead T-wave heterogeneity analysis to detect clinically significant coronary artery stenosis
    (2020) SILVA, Anderson C.; ANTONIO, Victor Z. de; SROUBEK, Jakub; GERVINO, Ernest; HO, Kalon; MEDEIROS, Sofia A.; SILVA, Fernanda Tessarolo; PEDREIRA, Giovanna C.; STOCCO, Fernando G.; NEARING, Bruce D.; VERRIER, Richard L.
    Background: Despite widespread use of ETT and vasodilator-stress with myocardial perfusion imaging (MPI) for noninvasive detection of flow-limiting coronary artery disease, there is continued need to improve diagnostic accuracy. We examinedwhether measurement of interlead T-wave heterogeneity (TWH) during exercise tolerance testing (ETT) or pharmacologic stress testing improves detection of stenoses in large epicardial coronary arteries. Methods: All 137 patients at our institution who underwent diagnostic coronary angiography within 0 to 5 days after ETT (N = 81) or dipyridamole IV infusion (N = 58) in 2016 were studied, including 2 patients with both tests. Cases (N= 93) had angiographically significant stenosis (>= 50% of left main or >= 70% of an epicardial coronary artery >= 2 mm in diameter); controls (N= 44) didnot. TWH, i.e., interlead splay of T waves, was determined by second central moment analysis from precordial leads by an investigator blinded to angiographic results. Results: At rest, TWH levels were similar for cases and controls. ETT and dipyridamole stress testing increased TWH by 69% (p < 0.0001) and 27% (p < 0.0001), respectively, in cases. In controls, TWH did not change. Areas under the ROC curves for TWH increase for any flow-limiting coronary artery stenosis were 0.737 (p < 0.0001) for ETT and 0.818 (p < 0.0001) for dipyridamole stress testing. By contrast, neither ST-segment changes during ETT (p = 0.12) nor MPI during dipyridamole stress testing (p= 0.60) discriminated cases fromcontrols. Conclusions: TWH measurement is a novel method that improves detection of angiographically confirmed flow-limiting stenoses in large epicardial coronary arteries during both ETT andMPI during pharmacologic stress testing with dipyridamole.
  • conferenceObject
    PULMONARY DELIVERY OF THE CLASS IC ANTIARRHYTHMIC AGENT FLECAINIDE EXERTS A PREDOMINANT EFFECT ON ATRIAL COMPARED TO VENTRICULAR DEPOLARIZATION DURATION REVEALED BY INTRACARDIAC RECORDINGS
    (2018) ANTONIO, Victor Zandona De; SILVA, Anderson; STOCCO, Fernando G.; RANGACHARI, Narsi; BELARDINELLI, Luiz; VERRIER, Richard; ISRAEL, Beth