GABRIEL OKAWA BELIZARIO
Projetos de Pesquisa
Unidades Organizacionais
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
17 resultados
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conferenceObject The impact of structured physical exercise on cognitive function of bipolar patients: A study protocol for a randomized controlled trial(2023) BELIZARIO, Gabriel; DUARTE, Cicera; NEVES, Lucas; MATHIAS, Karla; LAFER, Beny- Predominant polarity classification and associated clinical variables in bipolar disorder: A machine learning approach(2019) BELIZARIO, Gabriel Okawa; BORGES JUNIOR, Renato Gomes; SALVINI, Rogerio; LAFER, Beny; DIAS, Rodrigo da SilvaBackground: Bipolar disorder (BD) is a severe psychiatric disorder characterized by periodic episodes of manic and depressive symptomatology. Predominant polarity (PP) appears to be an important specifier of BD. The present study employed machine learning (ML) algorithms to accurately determine a patient ' s PP without the inclusion of number and polarity of past episodes, while exploring associations between PP and demographic and clinical variables. Methods: From a cohort of 148 BD patients, demographic and clinical variables were collected using a customized questionnaire and the SCID-CV. The algorithm employed was the Random-Forest method. The algorithm was programed to classify patients into either depressive or manic predominant polarities and to reveal which variables were associated to the specifier. Results: The algorithm attained an AUC ROC of 74.72% (95% CI = 72.29-77.15%) in classifying patients into either manic or depressive PP. The variables selected by the algorithm were: (1) age at first depressive episode; (2) number of hospitalizations; (3) BD Type II; (4) manic onset; (5) delusions; (6) psychotic features at onset; (7) tobacco addiction; (8) family history of BD; (9) hallucinations; and (10) comorbid anxiety disorders, (11) alcohol dependence, (12) eating disorders and (13) substance dependence. Limitations: The study is limited due to the small sample size, the inclusion of only self-reported and clinician-observed clinical variables and its cross-sectional design. Discussion: The results suggest that the ML approach could be effective in determining a patient ' s PP. Furthermore, although not previously reported, some variables, such as tobacco use and comorbid eating disorders, appear to be closely associated with PP.
- Variations in seasonal solar insolation are associated with a history of suicide attempts in bipolar I disorder(2021) BAUER, Michael; GLENN, Tasha; ACHTYES, Eric D.; ALDA, Martin; AGAOGLU, Esen; ALTINBAS, Kursat; ANDREASSEN, Ole A.; ANGELOPOULOS, Elias; ARDAU, Raffaella; VARES, Edgar Arrua; AYDIN, Memduha; CHIESA, Silvia; CROWE, Marie; CUOMO, Alessandro; DALLASPEZIA, Sara; ZOMPO, Maria Del; DESAI, Pratikkumar; DODD, Seetal; DONIX, Markus; ETAIN, Bruno; FAGIOLINI, Andrea; MOSCA, Enrica; FELLENDORF, Frederike T.; FERENSZTAJN-ROCHOWIAK, Ewa; FIEDOROWICZ, Jess G.; FOUNTOULAKIS, Kostas N.; FRYE, Mark A.; GEOFFROY, Pierre A.; GONZALEZ-PINTO, Ana; GOTTLIEB, John F.; GROF, Paul; HAARMAN, Bartholomeus C. M.; MOZZHEGOROV, Anton A.; HARIMA, Hirohiko; HASSE-SOUSA, Mathias; HENRY, Chantal; HOFFDING, Lone; HOUENOU, Josselin; IMBESI, Massimiliano; ISOMETSA, Erkki T.; IVKOVIC, Maja; JANNO, Sven; JOHNSEN, Simon; MUNOZ, Rodrigo; KAPCZINSKI, Flavio; KARAKATSOULIS, Gregory N.; KARDELL, Mathias; KESSING, Lars Vedel; KIM, Seong Jae; KOENIG, Barbara; KOT, Timur L.; KOVAL, Michael; KUNZ, Mauricio; LAFER, Beny; V, Starlin Mythri; LANDEN, Mikael; LARSEN, Erik R.; LENGER, Melanie; LEWITZKA, Ute; LICHT, Rasmus W.; LOPEZ-JARAMILLO, Carlos; MACKENZIE, Alan; MADSEN, Helle Ostergaard; MADSEN, Simone Alberte Kongstad A.; MAHADEVAN, Jayant; NACEF, Fethi; MAHARDIKA, Agustine; MANCHIA, Mirko; MARSH, Wendy; MARTINEZ-CENGOTITABENGOA, Monica; MARTINY, Klaus; MASHIMA, Yuki; MCLOUGHLIN, Declan M.; MEESTERS, Ybe; MELLE, Ingrid; MEZA-URZUA, Fatima; NADELLA, Ravi K.; MING, Mok Yee; MONTEITH, Scott; MOORTHY, Muthukumaran; MORKEN, Gunnar; NAKANOTANI, Takako; NIELSEN, Rene Ernst; O'DONOVAN, Claire; OMRANI, Adel; AYHAN, Yavuz; OSHER, Yamima; OUALI, Uta; PANTOVIC-STEFANOVIC, Maja; PARIWATCHARAKUL, Pornjira; PETITE, Joanne; PFENNIG, Andrea; RUIZ, Yolanda Pica; PILHATSCH, Maximilian; PINNA, Marco; POMPILI, Maurizio; BAETHGE, Christopher; PORTER, Richard; QUIROZ, Danilo; RABELO-DA-PONTE, Francisco Diego; RAMESAR, Raj; RASGON, Natalie; RATTA-APHA, Woraphat; RATZENHOFER, Michaela; REDAHAN, Maria; REDDY, M. S.; REIF, Andreas; BAUER, Rita; REININGHAUS, Eva Z.; RICHARDS, Jenny Gringer; RITTER, Philipp; RYBAKOWSKI, Janusz K.; SATHYAPUTRI, Leela; SCIPPA, Angela M.; SIMHANDL, Christian; SEVERUS, Emanuel; SMITH, Daniel; SMITH, Jose; BAUNE, Bernhard T.; STACKHOUSE JR., Paul W.; STEIN, Dan J.; STILWELL, Kellen; STREJILEVICH, Sergio; SU, Kuan-Pin; SUBRAMANIAM, Mythily; SULAIMAN, Ahmad Hatim; SUOMINEN, Kirsi; TANRA, Andi J.; TATEBAYASHI, Yoshitaka; BALABAN, Ceylan; TEH, Wen Lin; TONDO, Leonardo; TORRENT, Carla; TUINSTRA, Daniel; UCHIDA, Takahito; VAALER, Arne E.; VEEH, Julia; VIETA, Eduard; VISWANATH, Biju; YOLDI-NEGRETE, Maria; BECERRA-PALARS, Claudia; YALCINKAYA, Oguz Kaan; YOUNG, Allan H.; ZGUEB, Yosra; WHYBROW, Peter C.; BEHERE, Aniruddh P.; BEHERE, Prakash B.; BELETE, Habte; BELETE, Tilahun; BELIZARIO, Gabriel Okawa; BELLIVIER, Frank; BELMAKER, Robert H.; BENEDETTI, Francesco; BERK, Michael; BERSUDSKY, Yuly; BICAKCI, Sule; BIRABWA-OKETCHO, Harriet; BJELLA, Thomas D.; BRADY, Conan; CABRERA, Jorge; CAPPUCCIATI, Marco; CASTRO, Angela Marianne Paredes; CHEN, Wei-Ling; CHEUNG, Eric Y. WoBackground Bipolar disorder is associated with circadian disruption and a high risk of suicidal behavior. In a previous exploratory study of patients with bipolar I disorder, we found that a history of suicide attempts was associated with differences between winter and summer levels of solar insolation. The purpose of this study was to confirm this finding using international data from 42% more collection sites and 25% more countries. Methods Data analyzed were from 71 prior and new collection sites in 40 countries at a wide range of latitudes. The analysis included 4876 patients with bipolar I disorder, 45% more data than previously analyzed. Of the patients, 1496 (30.7%) had a history of suicide attempt. Solar insolation data, the amount of the sun's electromagnetic energy striking the surface of the earth, was obtained for each onset location (479 locations in 64 countries). Results This analysis confirmed the results of the exploratory study with the same best model and slightly better statistical significance. There was a significant inverse association between a history of suicide attempts and the ratio of mean winter insolation to mean summer insolation (mean winter insolation/mean summer insolation). This ratio is largest near the equator which has little change in solar insolation over the year, and smallest near the poles where the winter insolation is very small compared to the summer insolation. Other variables in the model associated with an increased risk of suicide attempts were a history of alcohol or substance abuse, female gender, and younger birth cohort. The winter/summer insolation ratio was also replaced with the ratio of minimum mean monthly insolation to the maximum mean monthly insolation to accommodate insolation patterns in the tropics, and nearly identical results were found. All estimated coefficients were significant at p < 0.01. Conclusion A large change in solar insolation, both between winter and summer and between the minimum and maximum monthly values, may increase the risk of suicide attempts in bipolar I disorder. With frequent circadian rhythm dysfunction and suicidal behavior in bipolar disorder, greater understanding of the optimal roles of daylight and electric lighting in circadian entrainment is needed.
conferenceObject Structured physical exercise in bipolar depression: A pilot study(2020) DUARTE, Cicera; BELIZARIO, Gabriel O.; MATHIAS, Karla; SILVA, Michele; ROBERTO, Paulo; GREVE, Julia; LAFER, Beny- Cognitive behavioral rehabilitation for bipolar disorder patients: A randomized controlled trial(2019) GOMES, Bernardo C.; ROCCA, Cristiana C.; BELIZARIO, Gabriel O.; FERNANDES, Francy de B. F.; VALOIS, Iolanda; OLMO, Giselle C.; FACHIN, Raquel V. P.; FARHAT, Luis C.; LAFER, BenyObjectives Bipolar disorder is frequently associated with cognitive impairment even during euthymia. Previous studies have reported significant impairments in functional and quality of life outcomes and a possible relationship between these variables and cognitive performance. Cognitive rehabilitation interventions have been proposed to address these outcomes but positive results are still scarce. The objective of the present study is to evaluate the efficacy of a new intervention developed to address both cognitive and functional impairment. Methods Thirty-nine individuals were included in this randomized controlled trial. All participants were evaluated by the Cambridge Neuropsychological Test Automated Battery (CANTAB) and completed functional and quality of life (QOL) scales. Patients were randomized to either treatment as usual (TAU) or Cognitive Behavior Rehabilitation (CBR), an add-on treatment delivered in 12 weekly group sessions. All individuals were revaluated after 12 weeks. Results A total of 39 bipolar type I or II patients were included in the analysis, 19 in the TAU group and 20 in the CBR condition. At the entrance of the study, both groups were statistically similar regarding clinical, socio-demographics and cognitive variables. After the end of the intervention, CBR individuals had significantly improved reaction time, visual memory and emotion recognition. In contrast, individuals in the CBR did not present a statistically change in functional and QOL scores after the 12-week intervention. Conclusions CBR intervention showed promising results in improving some of the commonly impaired cognitive domains in BD. A longer follow-up period may be necessary to detect changes in functional and QOL domains.
- Association between polarity of first episode and solar insolation in bipolar I disorder(2022) BAUER, Michael; GLENN, Tasha; ACHTYES, Eric D.; ALDA, Martin; AGAOGLU, Esen; ALTINBAS, Kursat; ANDREASSEN, Ole A.; ANGELOPOULOS, Elias; ARDAU, Raffaella; AYDIN, Memduha; AYHAN, Yavuz; DODD, Seetal; ETAIN, Bruno; FAGIOLINI, Andrea; FELLENDORF, Frederike T.; FERENSZTAJN-ROCHOWIAK, Ewa; FIEDOROWICZ, Jess G.; FOUNTOULAKIS, Kostas N.; FRYE, Mark A.; GEOFFROY, Pierre A.; GONZALEZ-PINTO, Ana; MUNOZ, Rodrigo; GOTTLIEB, John F.; GROF, Paul; HAARMAN, Bartholomeus C. M.; HARIMA, Hirohiko; HASSE-SOUSA, Mathias; HENRY, Chantal; HOFFDING, Lone; HOUENOU, Josselin; IMBESI, Massimiliano; ISOMETSA, Erkki T.; V, Starlin Mythri; IVKOVIC, Maja; JANNO, Sven; JOHNSEN, Simon; KAPCZINSKI, Flavio; KARAKATSOULIS, Gregory N.; KARDELL, Mathias; KESSING, Lars Vedel; KIM, Seong Jae; KOENIG, Barbara; KOT, Timur L.; NACEF, Fethi; KOVAL, Michael; KUNZ, Mauricio; LAFER, Beny; LANDEN, Mikael; LARSEN, Erik R.; LENGER, Melanie; LEWITZKA, Ute; LICHT, Rasmus W.; LOPEZ-JARAMILLO, Carlos; MACKENZIE, Alan; NADELLA, Ravi K.; MADSEN, Helle Ostergaard; MADSEN, Simone Alberte Kongstad A.; MAHADEVAN, Jayant; MAHARDIKA, Agustine; MANCHIA, Mirko; MARSH, Wendy; MARTINEZ-CENGOTITABENGOA, Monica; MARTINY, Klaus; MASHIMA, Yuki; MCLOUGHLIN, Declan M.; NAKANOTANI, Takako; MEESTERS, Ybe; MELLE, Ingrid; MEZA-URZUA, Fatima; MOK, Yee Ming; MONTEITH, Scott; MOORTHY, Muthukumaran; MORKEN, Gunnar; MOSCA, Enrica; MOZZHEGOROV, Anton A.; NIELSEN, Rene Ernst; O'DONOVAN, Claire; OMRANI, Adel; OSHER, Yamima; OUALI, Uta; BAETHGE, Christopher; PANTOVIC-STEFANOVIC, Maja; PARIWATCHARAKUL, Pornjira; PETITE, Joanne; PFENNIG, Andrea; RUIZ, Yolanda Pica; PINNA, Marco; POMPILI, Maurizio; PORTER, Richard; QUIROZ, Danilo; RABELO-DA-PONTE, Francisco Diego; BAUER, Rita; RAMESAR, Raj; RASGON, Natalie; RATTA-APHA, Woraphat; RATZENHOFER, Michaela; REDAHAN, Maria; REDDY, M. S.; REIF, Andreas; REININGHAUS, Eva Z.; RICHARDS, Jenny Gringer; RITTER, Philipp; BAUNE, Bernhard T.; RYBAKOWSKI, Janusz K.; SATHYAPUTRI, Leela; SCIPPA, Angela M.; SIMHANDL, Christian; SMITH, Daniel; SMITH, Jose; STACKHOUSE, Paul W.; STEIN, Dan J.; STILWELL, Kellen; STREJILEVICH, Sergio; BALABAN, Ceylan; SU, Kuan-Pin; SUBRAMANIAM, Mythily; SULAIMAN, Ahmad Hatim; SUOMINEN, Kirsi; TANRA, Andi J.; TATEBAYASHI, Yoshitaka; TEH, Wen Lin; TONDO, Leonardo; TORRENT, Carla; TUINSTRA, Daniel; BECERRA-PALARS, Claudia; UCHIDA, Takahito; VAALER, Arne E.; VIETA, Eduard; VISWANATH, Biju; YOLDI-NEGRETE, Maria; YALCINKAYA, Oguz Kaan; YOUNG, Allan H.; ZGUEB, Yosra; WHYBROW, Peter C.; BEHERE, Aniruddh P.; BEHERE, Prakash B.; BELETE, Habte; BELETE, Tilahun; BELIZARIO, Gabriel Okawa; BELLIVIER, Frank; BELMAKER, Robert H.; BENEDETTI, Francesco; BERK, Michael; BERSUDSKY, Yuly; BICAKCI, Sule; BIRABWA-OKETCHO, Harriet; BJELLA, Thomas D.; BRADY, Conan; CABRERA, Jorge; CAPPUCCIATI, Marco; CASTRO, Angela Marianne Paredes; CHEN, Wei-Ling; CHEUNG, Eric Y. W.; CHIESA, Silvia; CROWE, Marie; CUOMO, Alessandro; DALLASPEZIA, Sara; ZOMPO, Maria Del; DESAI, PratikkumarObjective: Circadian rhythm disruption is commonly observed in bipolar disorder (BD). Daylight is the most powerful signal to entrain the human circadian clock system. This exploratory study investigated if solar inso-lation at the onset location was associated with the polarity of the first episode of BD I. Solar insolation is the amount of electromagnetic energy from the Sun striking a surface area of the Earth. Methods: Data from 7488 patients with BD I were collected at 75 sites in 42 countries. The first episode occurred at 591 onset locations in 67 countries at a wide range of latitudes in both hemispheres. Solar insolation values were obtained for every onset location, and the ratio of the minimum mean monthly insolation to the maximum mean monthly insolation was calculated. This ratio is largest near the equator (with little change in solar insolation over the year), and smallest near the poles (where winter insolation is very small compared to summer insolation). This ratio also applies to tropical locations which may have a cloudy wet and clear dry season, rather than winter and summer. Results: The larger the change in solar insolation throughout the year (smaller the ratio between the minimum monthly and maximum monthly values), the greater the likelihood the first episode polarity was depression. Other associated variables were being female and increasing percentage of gross domestic product spent on country health expenditures. (All coefficients: P <= 0.001). Conclusion: Increased awareness and research into circadian dysfunction throughout the course of BD is warranted.
conferenceObject Impaired social cognition in bipolar disorder: A meta-analysis of theory of mind in euthymic patients(2020) ROTENBERG, Luisa deSiqueira; BELIZARIO, Gabriel O.; BERALDI, Gabriel; LAFER, Beny- Behavioral self-regulation in pediatric bipolar disorder and healthy offspring of bipolar patients(2023) ROCCA, Cristiana C. A.; CAETANO, Sheila C.; BELIZARIO, Gabriel Okawa; KLEINMAN, Ana; ABREU, Lena Nabuco de; LAFER, Beny; BUSATTO, Geraldo F.; GOMES, Bernardo C.Objectives: This study investigated behavioral self-regulation problems using the Children's Hostility Inventory (CHI) in pediatric bipolar disorder (PBD), healthy offspring of bipolar disorder patients (HOBD), and healthy controls (HC) without previous history of psychiatric disorders. Methods: The CHI was administered to 41 consecutive children and adolescents diagnosed with PBD, to 16 HOBD, and to 22 HC. The inventory assessed irritability, expression, hostility, and aggression and was completed by the children with the help of their mothers. Adolescents and their respective parents were interviewed separately using the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL). Results: All subscales of the CHI presented statistically significant differences, except for the subscale assessing feelings of suspicion. Pairwise comparisons revealed consistently significant differences between the PBD group and controls, indicating more self-regulation difficulties in the PBD group, represented by high levels of hostility and aggressive behavior. There were no significant differences between the PBD and HOBD groups. Conclusions: Future studies should further investigate if such behavior is state-dependent or a trait of bipolar juvenile expression. Expression of hostility and irritability should be considered relevant targets in psychosocial approaches addressing this population.
conferenceObject The impact of cannabis use on the course of bipolar disorder: A 8-year longitudinal study(2023) ESPINDOLA, Fernanda; RAMALHO, Alana; BELIZARIO, Gabriel Okawa; LAFER, Beny- Quality of life and clinical outcomes in bipolar disorder: An 8-year longitudinal study(2021) KHAFIF, Tatiana Cohab; BELIZARIO, Gabriel Okawa; SILVA, Michelle; GOMES, Bernardo Carramao; LAFER, BenyObjectives: This longitudinal study examined the relationship of Quality of Life (QOL) throughout an 8-year follow-up period with baseline and longitudinal clinical variables indicative of outcome in patients with Bipolar Disorder (BD). Methods: 36 participants, ages 18-70, were recruited from the Bipolar Disorder Research Program (PROMAN) outpatient clinic. Participants completed the WHOQOL-BREF questionnaire in 2009 (baseline), 2015 (6-years) and 2017 (8-years), with high scores being associated with better quality of life. Baseline clinical variables were collected through the Structured Clinical Interview for DSM-IV (SCID-IV) and a structured baseline interview for demographic and clinical assessment. Longitudinal clinical variables were collected through medical records, including mood charts and mood symptoms scales. Results: The results suggest that the QoL, as measured by the WHOQOL-BREF scale, is negatively affected by depressive episodes and is rather stable throughout the course of patients diagnosed with BD. In our study, all three scores were negatively correlated to depressive episodes, and one WHOQOL-BREF score was positively correlated to manic episodes, suggesting that higher scores, both at baseline and throughout the course of the disorder, may be associated to a higher occurrence of manic episodes, while lower QoL scores may be predictive of a higher occurrence of depressive episodes. Also, all three scores revealed significant positive correlations between themselves, suggesting QoL, as measured by the WHOQOL-BREF, remained constant throughout the 8 year observed period. Finally, patients presenting Obsessive Compulsive Disorder (OCD), Post-Traumatic Stress Disorder (PTSD) and substance abuse comorbidities revealed consistent lower WHOQOL-BREF scores, suggesting that these comorbidities may be an important predictor of QoL in BD patients.