GABRIEL OKAWA BELIZARIO
Projetos de Pesquisa
Unidades Organizacionais
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
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- Variations in seasonal solar insolation are associated with a history of suicide attempts in bipolar I disorder(2021) BAUER, Michael; GLENN, Tasha; ACHTYES, Eric D.; ALDA, Martin; AGAOGLU, Esen; ALTINBAS, Kursat; ANDREASSEN, Ole A.; ANGELOPOULOS, Elias; ARDAU, Raffaella; VARES, Edgar Arrua; AYDIN, Memduha; CHIESA, Silvia; CROWE, Marie; CUOMO, Alessandro; DALLASPEZIA, Sara; ZOMPO, Maria Del; DESAI, Pratikkumar; DODD, Seetal; DONIX, Markus; ETAIN, Bruno; FAGIOLINI, Andrea; MOSCA, Enrica; FELLENDORF, Frederike T.; FERENSZTAJN-ROCHOWIAK, Ewa; FIEDOROWICZ, Jess G.; FOUNTOULAKIS, Kostas N.; FRYE, Mark A.; GEOFFROY, Pierre A.; GONZALEZ-PINTO, Ana; GOTTLIEB, John F.; GROF, Paul; HAARMAN, Bartholomeus C. M.; MOZZHEGOROV, Anton A.; HARIMA, Hirohiko; HASSE-SOUSA, Mathias; HENRY, Chantal; HOFFDING, Lone; HOUENOU, Josselin; IMBESI, Massimiliano; ISOMETSA, Erkki T.; IVKOVIC, Maja; JANNO, Sven; JOHNSEN, Simon; MUNOZ, Rodrigo; KAPCZINSKI, Flavio; KARAKATSOULIS, Gregory N.; KARDELL, Mathias; KESSING, Lars Vedel; KIM, Seong Jae; KOENIG, Barbara; KOT, Timur L.; KOVAL, Michael; KUNZ, Mauricio; LAFER, Beny; V, Starlin Mythri; LANDEN, Mikael; LARSEN, Erik R.; LENGER, Melanie; LEWITZKA, Ute; LICHT, Rasmus W.; LOPEZ-JARAMILLO, Carlos; MACKENZIE, Alan; MADSEN, Helle Ostergaard; MADSEN, Simone Alberte Kongstad A.; MAHADEVAN, Jayant; NACEF, Fethi; MAHARDIKA, Agustine; MANCHIA, Mirko; MARSH, Wendy; MARTINEZ-CENGOTITABENGOA, Monica; MARTINY, Klaus; MASHIMA, Yuki; MCLOUGHLIN, Declan M.; MEESTERS, Ybe; MELLE, Ingrid; MEZA-URZUA, Fatima; NADELLA, Ravi K.; MING, Mok Yee; MONTEITH, Scott; MOORTHY, Muthukumaran; MORKEN, Gunnar; NAKANOTANI, Takako; NIELSEN, Rene Ernst; O'DONOVAN, Claire; OMRANI, Adel; AYHAN, Yavuz; OSHER, Yamima; OUALI, Uta; PANTOVIC-STEFANOVIC, Maja; PARIWATCHARAKUL, Pornjira; PETITE, Joanne; PFENNIG, Andrea; RUIZ, Yolanda Pica; PILHATSCH, Maximilian; PINNA, Marco; POMPILI, Maurizio; BAETHGE, Christopher; PORTER, Richard; QUIROZ, Danilo; RABELO-DA-PONTE, Francisco Diego; RAMESAR, Raj; RASGON, Natalie; RATTA-APHA, Woraphat; RATZENHOFER, Michaela; REDAHAN, Maria; REDDY, M. S.; REIF, Andreas; BAUER, Rita; REININGHAUS, Eva Z.; RICHARDS, Jenny Gringer; RITTER, Philipp; RYBAKOWSKI, Janusz K.; SATHYAPUTRI, Leela; SCIPPA, Angela M.; SIMHANDL, Christian; SEVERUS, Emanuel; SMITH, Daniel; SMITH, Jose; BAUNE, Bernhard T.; STACKHOUSE JR., Paul W.; STEIN, Dan J.; STILWELL, Kellen; STREJILEVICH, Sergio; SU, Kuan-Pin; SUBRAMANIAM, Mythily; SULAIMAN, Ahmad Hatim; SUOMINEN, Kirsi; TANRA, Andi J.; TATEBAYASHI, Yoshitaka; BALABAN, Ceylan; TEH, Wen Lin; TONDO, Leonardo; TORRENT, Carla; TUINSTRA, Daniel; UCHIDA, Takahito; VAALER, Arne E.; VEEH, Julia; VIETA, Eduard; VISWANATH, Biju; YOLDI-NEGRETE, Maria; BECERRA-PALARS, Claudia; YALCINKAYA, Oguz Kaan; YOUNG, Allan H.; ZGUEB, Yosra; WHYBROW, Peter C.; BEHERE, Aniruddh P.; BEHERE, Prakash B.; BELETE, Habte; BELETE, Tilahun; BELIZARIO, Gabriel Okawa; BELLIVIER, Frank; BELMAKER, Robert H.; BENEDETTI, Francesco; BERK, Michael; BERSUDSKY, Yuly; BICAKCI, Sule; BIRABWA-OKETCHO, Harriet; BJELLA, Thomas D.; BRADY, Conan; CABRERA, Jorge; CAPPUCCIATI, Marco; CASTRO, Angela Marianne Paredes; CHEN, Wei-Ling; CHEUNG, Eric Y. WoBackground Bipolar disorder is associated with circadian disruption and a high risk of suicidal behavior. In a previous exploratory study of patients with bipolar I disorder, we found that a history of suicide attempts was associated with differences between winter and summer levels of solar insolation. The purpose of this study was to confirm this finding using international data from 42% more collection sites and 25% more countries. Methods Data analyzed were from 71 prior and new collection sites in 40 countries at a wide range of latitudes. The analysis included 4876 patients with bipolar I disorder, 45% more data than previously analyzed. Of the patients, 1496 (30.7%) had a history of suicide attempt. Solar insolation data, the amount of the sun's electromagnetic energy striking the surface of the earth, was obtained for each onset location (479 locations in 64 countries). Results This analysis confirmed the results of the exploratory study with the same best model and slightly better statistical significance. There was a significant inverse association between a history of suicide attempts and the ratio of mean winter insolation to mean summer insolation (mean winter insolation/mean summer insolation). This ratio is largest near the equator which has little change in solar insolation over the year, and smallest near the poles where the winter insolation is very small compared to the summer insolation. Other variables in the model associated with an increased risk of suicide attempts were a history of alcohol or substance abuse, female gender, and younger birth cohort. The winter/summer insolation ratio was also replaced with the ratio of minimum mean monthly insolation to the maximum mean monthly insolation to accommodate insolation patterns in the tropics, and nearly identical results were found. All estimated coefficients were significant at p < 0.01. Conclusion A large change in solar insolation, both between winter and summer and between the minimum and maximum monthly values, may increase the risk of suicide attempts in bipolar I disorder. With frequent circadian rhythm dysfunction and suicidal behavior in bipolar disorder, greater understanding of the optimal roles of daylight and electric lighting in circadian entrainment is needed.
- Quality of life and clinical outcomes in bipolar disorder: An 8-year longitudinal study(2021) KHAFIF, Tatiana Cohab; BELIZARIO, Gabriel Okawa; SILVA, Michelle; GOMES, Bernardo Carramao; LAFER, BenyObjectives: This longitudinal study examined the relationship of Quality of Life (QOL) throughout an 8-year follow-up period with baseline and longitudinal clinical variables indicative of outcome in patients with Bipolar Disorder (BD). Methods: 36 participants, ages 18-70, were recruited from the Bipolar Disorder Research Program (PROMAN) outpatient clinic. Participants completed the WHOQOL-BREF questionnaire in 2009 (baseline), 2015 (6-years) and 2017 (8-years), with high scores being associated with better quality of life. Baseline clinical variables were collected through the Structured Clinical Interview for DSM-IV (SCID-IV) and a structured baseline interview for demographic and clinical assessment. Longitudinal clinical variables were collected through medical records, including mood charts and mood symptoms scales. Results: The results suggest that the QoL, as measured by the WHOQOL-BREF scale, is negatively affected by depressive episodes and is rather stable throughout the course of patients diagnosed with BD. In our study, all three scores were negatively correlated to depressive episodes, and one WHOQOL-BREF score was positively correlated to manic episodes, suggesting that higher scores, both at baseline and throughout the course of the disorder, may be associated to a higher occurrence of manic episodes, while lower QoL scores may be predictive of a higher occurrence of depressive episodes. Also, all three scores revealed significant positive correlations between themselves, suggesting QoL, as measured by the WHOQOL-BREF, remained constant throughout the 8 year observed period. Finally, patients presenting Obsessive Compulsive Disorder (OCD), Post-Traumatic Stress Disorder (PTSD) and substance abuse comorbidities revealed consistent lower WHOQOL-BREF scores, suggesting that these comorbidities may be an important predictor of QoL in BD patients.
- Personality traits and parenting styles in boys victims of sexual abuse: a pilot study(2021) ABECHE, Camila Vaz; KHAFIF, Tatiana Cohab; BELIZARIO, Gabriel Okawa; SILVA, Thiago Fernando Da; HARKALY, Giulia; GOMIDE, Paula Inez Cunha; SERAFIM, Antonio De PaduaObjective: We examined the association between personality traits and parenting styles in boys victims of sexual abuse (SA). Methods: Sixty-two (62) boys were divided into two groups: 32 (Victims of SA group, age 11.7 +/- 1.28) and 30 non-victims of SA (Comparison group, age 11.6 +/- 1.22). All participants completed the Eysenck Personality Questionnaire (EPQ-J) and the Parenting Styles Inventory (PSI). The intelligence quotient (IQ) was also assessed. Results: Both groups did not differ in terms of IQ. In the SA group, men (97%) were the biggest abusers, 85% of the parents were divorced and the father was the biggest aggressor (44%). The SA victims had higher neuroticism (p <0.001) and identified riskier parental practices, while the comparison group reported good parental practices (p<0.05). The results of the logistic regression analysis showed that higher negative paternal parental style scores increase the chance of belonging to the victims group. Discussion: Victims of SA present a higher risk of neuroticism and perception of dysfunctional family dynamics, with seriously reversed social roles. Further studies are needed to investigate the behavioral, cognitive, emotional, personality and parental styles, and the development of psychological intervention programs and other professional practices for victims of SA and their families in various contexts of violence.