GABRIEL OKAWA BELIZARIO
Projetos de Pesquisa
Unidades Organizacionais
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
7 resultados
Resultados de Busca
Agora exibindo 1 - 7 de 7
conferenceObject The impact of structured physical exercise on cognitive function of bipolar patients: A study protocol for a randomized controlled trial(2023) BELIZARIO, Gabriel; DUARTE, Cicera; NEVES, Lucas; MATHIAS, Karla; LAFER, Beny- Behavioral self-regulation in pediatric bipolar disorder and healthy offspring of bipolar patients(2023) ROCCA, Cristiana C. A.; CAETANO, Sheila C.; BELIZARIO, Gabriel Okawa; KLEINMAN, Ana; ABREU, Lena Nabuco de; LAFER, Beny; BUSATTO, Geraldo F.; GOMES, Bernardo C.Objectives: This study investigated behavioral self-regulation problems using the Children's Hostility Inventory (CHI) in pediatric bipolar disorder (PBD), healthy offspring of bipolar disorder patients (HOBD), and healthy controls (HC) without previous history of psychiatric disorders. Methods: The CHI was administered to 41 consecutive children and adolescents diagnosed with PBD, to 16 HOBD, and to 22 HC. The inventory assessed irritability, expression, hostility, and aggression and was completed by the children with the help of their mothers. Adolescents and their respective parents were interviewed separately using the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL). Results: All subscales of the CHI presented statistically significant differences, except for the subscale assessing feelings of suspicion. Pairwise comparisons revealed consistently significant differences between the PBD group and controls, indicating more self-regulation difficulties in the PBD group, represented by high levels of hostility and aggressive behavior. There were no significant differences between the PBD and HOBD groups. Conclusions: Future studies should further investigate if such behavior is state-dependent or a trait of bipolar juvenile expression. Expression of hostility and irritability should be considered relevant targets in psychosocial approaches addressing this population.
conferenceObject The impact of cannabis use on the course of bipolar disorder: A 8-year longitudinal study(2023) ESPINDOLA, Fernanda; RAMALHO, Alana; BELIZARIO, Gabriel Okawa; LAFER, BenyconferenceObject Family history of suicide attempts as a risk factor for suicide attempts in patients with bipolar disorder(2023) KHAFIF, Tatiana; BELIZARIO, Gabriel Okawa; LAFER, Beny- Structured physical exercise for bipolar depression: an open-label, proof-of concept study(2023) LAFER, Beny; DUARTE, Cicera Claudinea; GREVE, Julia Maria D'Andrea; SILVA, Paulo Roberto dos Santos; ALMEIDA, Karla Mathias de; BELIZARIO, Gabriel Okawa; NEVES, Lucas MeloBackgroundPhysical exercise (PE) is a recommended lifestyle intervention for different mental disorders and has shown specific positive therapeutic effects in unipolar depressive disorder. Considering the similar symptomatology of the depressive phase in patients with bipolar disorder (BD) and unipolar depressive disorder, it is reasonable to suggest that PE may also be beneficial for bipolar depression. However, there is an absence of studies evaluating the antidepressant effect of a structured PE intervention in BD.MethodsThis is an open-label, single-arm study trial. Fifteen patients with a diagnosis of BD Type I or Type II, presenting a depressive episode were included in the study. After physical and functional evaluation, patients participated in supervised training sessions with aerobics followed by strength exercises, three times per week, for 12 weeks (36 training sessions). Depressive and manic symptoms were assessed at baseline and 2, 4, 8, and 12 weeks. Additionally, quality of Life and functioning were assessed at baseline and 4, 8, and 12 weeks). Finally, we tested cardiorespiratory fitness, muscle strength and body composition at baseline and week-12.ResultsThe mean (+/- SD) Montgomery Asberg Depression Rating Scale (MADRS) score at baseline was 23.6 +/- 8.3 points and after 12 weeks of PE the mean score was 10.2 +/- 4.8 points. Nine patients (82%) presented an antidepressant response defined as a reduction of more than 50% of depressive symptoms at week 12 with five of those patients (45%) presenting criteria for full remission. A large and significant Cohen's D Effect Size (pre-post) was verified for MADRS reduction [1.98 (95% Confidence interval = 0.88 to 3.08)]. We did not detect a significant change in manic symptoms, functioning, and quality of life during the 12-week follow-up. At week-12, all patients increased their muscular strength (one repetition maximal test - 1RM) and reduced the percentage of body fat (spectral bioelectrical impedance analysis).ConclusionsThis study, using rigorous criteria and a structured intervention, provides valid pilot data, showing the feasibility of a structured PE intervention for the treatment of depressive symptoms in BD, and suggesting a potential adjunctive antidepressant effect. Moreover, PE showed a positive impact on muscle strength and body composition. This should be further verified by randomized controlled studies.
- Self-regulation in youth with bipolar disorder(2023) KHAFIF, Tatiana Cohab; KLEINMAN, Ana; ROCCA, Cristiana Castanho de Almeida; BELIZARIO, Gabriel Okawa; NADER, Edmir; CAETANO, Sheila C.; LAFER, BenyObjectives: To examine the composition of self-regulation in pediatric bipolar disorder (PBD) through the relationship between executive functions, emotion processing, and family environmental factors. Methods: 58 participants (36 with PBD and 22 controls), ages 12-17, were assessed using the Emotion Recognition Test (PENNCNB ER-40), and Expressed Emotion Adjective Checklist Results: Adolescents with PBD displayed significant deficits in all three spheres when compared to the control group. Emotion processing correlated negatively with inhibition and attention, and correlated positively with mental flexibility/working memory. Family environmental factors correlated negatively with mental flexibility/working memory and emotion processing, and positively with attention and inhibition. These correlations indicate that better inhibitory control, attention, and mental flexibility/ working memory are associated with greater emotion processing and a fitter family environment. Conclusion: This study is the first to investigate all of the components of self-regulation deficits simultaneously in patients with PBD. Results suggest that self-regulation is essential for a comprehensive perspective of PBD and should be assessed in an integrative and multifaceted way. Understanding that self-regulation is impacted by the abovementioned factors should influence treatment and improve the functional impairments of daily life observed in this population.
- Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder(2023) BAUER, Michael; GLENN, Tasha; ACHTYES, Eric D.; ALDA, Martin; AGAOGLU, Esen; ALTINBAS, Kuersat; ANDREASSEN, Ole A.; ANGELOPOULOS, Elias; ARDAU, Raffaella; AYDIN, Memduha; AYHAN, Yavuz; TATEBAYASHI, Yoshitaka; TEH, Wen Lin; BECERRA-PALARS, Claudia; TONDO, Leonardo; TORRENT, Carla; DESAI, Pratikkumar; TUINSTRA, Daniel; UCHIDA, Takahito; VAALER, Arne E.; VIETA, Eduard; JANNO, Sven; VISWANATH, Biju; YOLDI-NEGRETE, Maria; YALCINKAYA, Oguz Kaan; YOUNG, Allan H.; BEHERE, Aniruddh P.; ZGUEB, Yosra; DODD, Seetal; WHYBROW, Peter C.; BEHERE, Prakash B.; BELETE, Habte; JOHNSEN, Simon; BELETE, Tilahun; BELIZARIO, Gabriel Okawa; BELLIVIER, Frank; BELMAKER, Robert H.; BENEDETTI, Francesco; BERK, Michael; BERSUDSKY, Yuly; ETAIN, Bruno; BICAKCI, Sule; BIRABWA-OKETCHO, Harriet; KAPCZINSKI, Flavio; BJELLA, Thomas D.; BRADY, Conan; CABRERA, Jorge; CAPPUCCIATI, Marco; CASTRO, Angela Marianne Paredes; CHEN, Wei-Ling; CHEUNG, Eric Y. W.; CHIESA, Silvia; FAGIOLINI, Andrea; CROWE, Marie; KARAKATSOULIS, Gregory N.; CUOMO, Alessandro; FELLENDORF, Frederike T.; FERENSZTAJN-ROCHOWIAK, Ewa; FIEDOROWICZ, Jess G.; FOUNTOULAKIS, Kostas N.; MOSCA, Enrica; FRYE, Mark A.; GEOFFROY, Pierre A.; GITLIN, Michael J.; GONZALEZ-PINTO, Ana.; KARDELL, Mathias; GOTTLIEB, John F.; GROF, Paul; HAARMAN, Bartholomeus C. M.; HARIMA, Hirohiko; HASSE-SOUSA, Mathias; HENRY, Chantal; MOZZHEGOROV, Anton A.; HOFFDING, Lone; HOUENOU, Josselin; IMBESI, Massimiliano; MUNOZ, Rodrigo; ISOMETSA, Erkki T.; IVKOVIC, Maja; KESSING, Lars Vedel; KIM, Seong Jae; KOENIG, Barbara; KOT, Timur L.; RATTA-APHA, Woraphat; KOVAL, Michael; KUNZ, Mauricio; LAFER, Beny; LANDEN, Mikael; LARSEN, Erik R.; LENGER, Melanie; MYTHRI, Starlin V.; LICHT, Rasmus W.; LOPEZ-JARAMILLO, Carlos; MACKENZIE, Alan; RATZENHOFER, Michaela; MADSEN, Helle Ostergaard; MADSEN, Simone Alberte Kongstad A.; MAHADEVAN, Jayant; MAHARDIKA, Agustine; MANCHIA, Mirko; MARSH, Wendy; MARTINEZ-CENGOTITABENGOA, Monica; NACEF, Fethi; MARTINI, Julia; MARTINY, Klaus; REDAHAN, Maria; MASHIMA, Yuki; MCLOUGHLIN, Declan M.; MEESTERS, Ybe; MELLE, Ingrid; MEZA-URZUA, Fatima; MIKOLAS, Pavol; MOK, Yee Ming; MONTEITH, Scott; NADELLA, Ravi K.; MOORTHY, Muthukumaran; REDDY, M. S.; MORKEN, Gunnar; NAKANOTANI, Takako; NIELSEN, Rene Ernst; O'DONOVAN, Claire; OMRANI, Adel; BAETHGE, Christopher; OSHER, Yamima; OUALI, Uta; PANTOVIC-STEFANOVIC, Maja; PARIWATCHARAKUL, Pornjira; REIF, Andreas; PETITE, Joanne; PETZOLD, Johannes; PFENNIG, Andrea; RUIZ, Yolanda Pica; PINNA, Marco; POMPILI, Maurizio; BAUER, Rita; PORTER, Richard J.; QUIROZ, Danilo; RABELO-DA-PONTE, Francisco Diego; BAUNE, Bernhard T.; RAMESAR, Raj; RASGON, Natalie; REININGHAUS, Eva Z.; RICHARDS, Jenny Gringer; RITTER, Philipp; RYBAKOWSKI, Janusz K.; DALLASPEZIA, Sara; SATHYAPUTRI, Leela; SCIPPA, Angela M.; SIMHANDL, Christian; SMITH, Daniel; SMITH, Jose; STACKHOUSE, Jr Paul W.; BALABAN, Ceylan; STEIN, Dan J.; STILWELL, Kellen; STREJILEVICH, Sergio; ZOMPO, Maria Del; SU, Kuan-Pin; SUBRAMANIAM, Mythily; SULAIMAN, Ahmad Hatim; SUOMINEN, Kirsi; TANRA, Andi J.BackgroundSunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin D has widespread effects on brain function in both developing and adult brains. However, many people live at latitudes (about > 40 N or S) that do not receive enough UVB in winter to produce vitamin D. This exploratory study investigated the association between the age of onset of bipolar I disorder and the threshold for UVB sufficient for vitamin D production in a large global sample.MethodsData for 6972 patients with bipolar I disorder were obtained at 75 collection sites in 41 countries in both hemispheres. The best model to assess the relation between the threshold for UVB sufficient for vitamin D production and age of onset included 1 or more months below the threshold, family history of mood disorders, and birth cohort. All coefficients estimated at P <= 0.001.ResultsThe 6972 patients had an onset in 582 locations in 70 countries, with a mean age of onset of 25.6 years. Of the onset locations, 34.0% had at least 1 month below the threshold for UVB sufficient for vitamin D production. The age of onset at locations with 1 or more months of less than or equal to the threshold for UVB was 1.66 years younger.ConclusionUVB and vitamin D may have an important influence on the development of bipolar disorder. Study limitations included a lack of data on patient vitamin D levels, lifestyles, or supplement use. More study of the impacts of UVB and vitamin D in bipolar disorder is needed to evaluate this supposition.