GABRIEL OKAWA BELIZARIO
Projetos de Pesquisa
Unidades Organizacionais
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
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- Variations in seasonal solar insolation are associated with a history of suicide attempts in bipolar I disorder(2021) BAUER, Michael; GLENN, Tasha; ACHTYES, Eric D.; ALDA, Martin; AGAOGLU, Esen; ALTINBAS, Kursat; ANDREASSEN, Ole A.; ANGELOPOULOS, Elias; ARDAU, Raffaella; VARES, Edgar Arrua; AYDIN, Memduha; CHIESA, Silvia; CROWE, Marie; CUOMO, Alessandro; DALLASPEZIA, Sara; ZOMPO, Maria Del; DESAI, Pratikkumar; DODD, Seetal; DONIX, Markus; ETAIN, Bruno; FAGIOLINI, Andrea; MOSCA, Enrica; FELLENDORF, Frederike T.; FERENSZTAJN-ROCHOWIAK, Ewa; FIEDOROWICZ, Jess G.; FOUNTOULAKIS, Kostas N.; FRYE, Mark A.; GEOFFROY, Pierre A.; GONZALEZ-PINTO, Ana; GOTTLIEB, John F.; GROF, Paul; HAARMAN, Bartholomeus C. M.; MOZZHEGOROV, Anton A.; HARIMA, Hirohiko; HASSE-SOUSA, Mathias; HENRY, Chantal; HOFFDING, Lone; HOUENOU, Josselin; IMBESI, Massimiliano; ISOMETSA, Erkki T.; IVKOVIC, Maja; JANNO, Sven; JOHNSEN, Simon; MUNOZ, Rodrigo; KAPCZINSKI, Flavio; KARAKATSOULIS, Gregory N.; KARDELL, Mathias; KESSING, Lars Vedel; KIM, Seong Jae; KOENIG, Barbara; KOT, Timur L.; KOVAL, Michael; KUNZ, Mauricio; LAFER, Beny; V, Starlin Mythri; LANDEN, Mikael; LARSEN, Erik R.; LENGER, Melanie; LEWITZKA, Ute; LICHT, Rasmus W.; LOPEZ-JARAMILLO, Carlos; MACKENZIE, Alan; MADSEN, Helle Ostergaard; MADSEN, Simone Alberte Kongstad A.; MAHADEVAN, Jayant; NACEF, Fethi; MAHARDIKA, Agustine; MANCHIA, Mirko; MARSH, Wendy; MARTINEZ-CENGOTITABENGOA, Monica; MARTINY, Klaus; MASHIMA, Yuki; MCLOUGHLIN, Declan M.; MEESTERS, Ybe; MELLE, Ingrid; MEZA-URZUA, Fatima; NADELLA, Ravi K.; MING, Mok Yee; MONTEITH, Scott; MOORTHY, Muthukumaran; MORKEN, Gunnar; NAKANOTANI, Takako; NIELSEN, Rene Ernst; O'DONOVAN, Claire; OMRANI, Adel; AYHAN, Yavuz; OSHER, Yamima; OUALI, Uta; PANTOVIC-STEFANOVIC, Maja; PARIWATCHARAKUL, Pornjira; PETITE, Joanne; PFENNIG, Andrea; RUIZ, Yolanda Pica; PILHATSCH, Maximilian; PINNA, Marco; POMPILI, Maurizio; BAETHGE, Christopher; PORTER, Richard; QUIROZ, Danilo; RABELO-DA-PONTE, Francisco Diego; RAMESAR, Raj; RASGON, Natalie; RATTA-APHA, Woraphat; RATZENHOFER, Michaela; REDAHAN, Maria; REDDY, M. S.; REIF, Andreas; BAUER, Rita; REININGHAUS, Eva Z.; RICHARDS, Jenny Gringer; RITTER, Philipp; RYBAKOWSKI, Janusz K.; SATHYAPUTRI, Leela; SCIPPA, Angela M.; SIMHANDL, Christian; SEVERUS, Emanuel; SMITH, Daniel; SMITH, Jose; BAUNE, Bernhard T.; STACKHOUSE JR., Paul W.; STEIN, Dan J.; STILWELL, Kellen; STREJILEVICH, Sergio; SU, Kuan-Pin; SUBRAMANIAM, Mythily; SULAIMAN, Ahmad Hatim; SUOMINEN, Kirsi; TANRA, Andi J.; TATEBAYASHI, Yoshitaka; BALABAN, Ceylan; TEH, Wen Lin; TONDO, Leonardo; TORRENT, Carla; TUINSTRA, Daniel; UCHIDA, Takahito; VAALER, Arne E.; VEEH, Julia; VIETA, Eduard; VISWANATH, Biju; YOLDI-NEGRETE, Maria; BECERRA-PALARS, Claudia; YALCINKAYA, Oguz Kaan; YOUNG, Allan H.; ZGUEB, Yosra; WHYBROW, Peter C.; BEHERE, Aniruddh P.; BEHERE, Prakash B.; BELETE, Habte; BELETE, Tilahun; BELIZARIO, Gabriel Okawa; BELLIVIER, Frank; BELMAKER, Robert H.; BENEDETTI, Francesco; BERK, Michael; BERSUDSKY, Yuly; BICAKCI, Sule; BIRABWA-OKETCHO, Harriet; BJELLA, Thomas D.; BRADY, Conan; CABRERA, Jorge; CAPPUCCIATI, Marco; CASTRO, Angela Marianne Paredes; CHEN, Wei-Ling; CHEUNG, Eric Y. WoBackground Bipolar disorder is associated with circadian disruption and a high risk of suicidal behavior. In a previous exploratory study of patients with bipolar I disorder, we found that a history of suicide attempts was associated with differences between winter and summer levels of solar insolation. The purpose of this study was to confirm this finding using international data from 42% more collection sites and 25% more countries. Methods Data analyzed were from 71 prior and new collection sites in 40 countries at a wide range of latitudes. The analysis included 4876 patients with bipolar I disorder, 45% more data than previously analyzed. Of the patients, 1496 (30.7%) had a history of suicide attempt. Solar insolation data, the amount of the sun's electromagnetic energy striking the surface of the earth, was obtained for each onset location (479 locations in 64 countries). Results This analysis confirmed the results of the exploratory study with the same best model and slightly better statistical significance. There was a significant inverse association between a history of suicide attempts and the ratio of mean winter insolation to mean summer insolation (mean winter insolation/mean summer insolation). This ratio is largest near the equator which has little change in solar insolation over the year, and smallest near the poles where the winter insolation is very small compared to the summer insolation. Other variables in the model associated with an increased risk of suicide attempts were a history of alcohol or substance abuse, female gender, and younger birth cohort. The winter/summer insolation ratio was also replaced with the ratio of minimum mean monthly insolation to the maximum mean monthly insolation to accommodate insolation patterns in the tropics, and nearly identical results were found. All estimated coefficients were significant at p < 0.01. Conclusion A large change in solar insolation, both between winter and summer and between the minimum and maximum monthly values, may increase the risk of suicide attempts in bipolar I disorder. With frequent circadian rhythm dysfunction and suicidal behavior in bipolar disorder, greater understanding of the optimal roles of daylight and electric lighting in circadian entrainment is needed.
- Structured physical exercise for bipolar depression: an open-label, proof-of concept study(2023) LAFER, Beny; DUARTE, Cicera Claudinea; GREVE, Julia Maria D'Andrea; SILVA, Paulo Roberto dos Santos; ALMEIDA, Karla Mathias de; BELIZARIO, Gabriel Okawa; NEVES, Lucas MeloBackgroundPhysical exercise (PE) is a recommended lifestyle intervention for different mental disorders and has shown specific positive therapeutic effects in unipolar depressive disorder. Considering the similar symptomatology of the depressive phase in patients with bipolar disorder (BD) and unipolar depressive disorder, it is reasonable to suggest that PE may also be beneficial for bipolar depression. However, there is an absence of studies evaluating the antidepressant effect of a structured PE intervention in BD.MethodsThis is an open-label, single-arm study trial. Fifteen patients with a diagnosis of BD Type I or Type II, presenting a depressive episode were included in the study. After physical and functional evaluation, patients participated in supervised training sessions with aerobics followed by strength exercises, three times per week, for 12 weeks (36 training sessions). Depressive and manic symptoms were assessed at baseline and 2, 4, 8, and 12 weeks. Additionally, quality of Life and functioning were assessed at baseline and 4, 8, and 12 weeks). Finally, we tested cardiorespiratory fitness, muscle strength and body composition at baseline and week-12.ResultsThe mean (+/- SD) Montgomery Asberg Depression Rating Scale (MADRS) score at baseline was 23.6 +/- 8.3 points and after 12 weeks of PE the mean score was 10.2 +/- 4.8 points. Nine patients (82%) presented an antidepressant response defined as a reduction of more than 50% of depressive symptoms at week 12 with five of those patients (45%) presenting criteria for full remission. A large and significant Cohen's D Effect Size (pre-post) was verified for MADRS reduction [1.98 (95% Confidence interval = 0.88 to 3.08)]. We did not detect a significant change in manic symptoms, functioning, and quality of life during the 12-week follow-up. At week-12, all patients increased their muscular strength (one repetition maximal test - 1RM) and reduced the percentage of body fat (spectral bioelectrical impedance analysis).ConclusionsThis study, using rigorous criteria and a structured intervention, provides valid pilot data, showing the feasibility of a structured PE intervention for the treatment of depressive symptoms in BD, and suggesting a potential adjunctive antidepressant effect. Moreover, PE showed a positive impact on muscle strength and body composition. This should be further verified by randomized controlled studies.
- Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder(2023) BAUER, Michael; GLENN, Tasha; ACHTYES, Eric D.; ALDA, Martin; AGAOGLU, Esen; ALTINBAS, Kuersat; ANDREASSEN, Ole A.; ANGELOPOULOS, Elias; ARDAU, Raffaella; AYDIN, Memduha; AYHAN, Yavuz; TATEBAYASHI, Yoshitaka; TEH, Wen Lin; BECERRA-PALARS, Claudia; TONDO, Leonardo; TORRENT, Carla; DESAI, Pratikkumar; TUINSTRA, Daniel; UCHIDA, Takahito; VAALER, Arne E.; VIETA, Eduard; JANNO, Sven; VISWANATH, Biju; YOLDI-NEGRETE, Maria; YALCINKAYA, Oguz Kaan; YOUNG, Allan H.; BEHERE, Aniruddh P.; ZGUEB, Yosra; DODD, Seetal; WHYBROW, Peter C.; BEHERE, Prakash B.; BELETE, Habte; JOHNSEN, Simon; BELETE, Tilahun; BELIZARIO, Gabriel Okawa; BELLIVIER, Frank; BELMAKER, Robert H.; BENEDETTI, Francesco; BERK, Michael; BERSUDSKY, Yuly; ETAIN, Bruno; BICAKCI, Sule; BIRABWA-OKETCHO, Harriet; KAPCZINSKI, Flavio; BJELLA, Thomas D.; BRADY, Conan; CABRERA, Jorge; CAPPUCCIATI, Marco; CASTRO, Angela Marianne Paredes; CHEN, Wei-Ling; CHEUNG, Eric Y. W.; CHIESA, Silvia; FAGIOLINI, Andrea; CROWE, Marie; KARAKATSOULIS, Gregory N.; CUOMO, Alessandro; FELLENDORF, Frederike T.; FERENSZTAJN-ROCHOWIAK, Ewa; FIEDOROWICZ, Jess G.; FOUNTOULAKIS, Kostas N.; MOSCA, Enrica; FRYE, Mark A.; GEOFFROY, Pierre A.; GITLIN, Michael J.; GONZALEZ-PINTO, Ana.; KARDELL, Mathias; GOTTLIEB, John F.; GROF, Paul; HAARMAN, Bartholomeus C. M.; HARIMA, Hirohiko; HASSE-SOUSA, Mathias; HENRY, Chantal; MOZZHEGOROV, Anton A.; HOFFDING, Lone; HOUENOU, Josselin; IMBESI, Massimiliano; MUNOZ, Rodrigo; ISOMETSA, Erkki T.; IVKOVIC, Maja; KESSING, Lars Vedel; KIM, Seong Jae; KOENIG, Barbara; KOT, Timur L.; RATTA-APHA, Woraphat; KOVAL, Michael; KUNZ, Mauricio; LAFER, Beny; LANDEN, Mikael; LARSEN, Erik R.; LENGER, Melanie; MYTHRI, Starlin V.; LICHT, Rasmus W.; LOPEZ-JARAMILLO, Carlos; MACKENZIE, Alan; RATZENHOFER, Michaela; MADSEN, Helle Ostergaard; MADSEN, Simone Alberte Kongstad A.; MAHADEVAN, Jayant; MAHARDIKA, Agustine; MANCHIA, Mirko; MARSH, Wendy; MARTINEZ-CENGOTITABENGOA, Monica; NACEF, Fethi; MARTINI, Julia; MARTINY, Klaus; REDAHAN, Maria; MASHIMA, Yuki; MCLOUGHLIN, Declan M.; MEESTERS, Ybe; MELLE, Ingrid; MEZA-URZUA, Fatima; MIKOLAS, Pavol; MOK, Yee Ming; MONTEITH, Scott; NADELLA, Ravi K.; MOORTHY, Muthukumaran; REDDY, M. S.; MORKEN, Gunnar; NAKANOTANI, Takako; NIELSEN, Rene Ernst; O'DONOVAN, Claire; OMRANI, Adel; BAETHGE, Christopher; OSHER, Yamima; OUALI, Uta; PANTOVIC-STEFANOVIC, Maja; PARIWATCHARAKUL, Pornjira; REIF, Andreas; PETITE, Joanne; PETZOLD, Johannes; PFENNIG, Andrea; RUIZ, Yolanda Pica; PINNA, Marco; POMPILI, Maurizio; BAUER, Rita; PORTER, Richard J.; QUIROZ, Danilo; RABELO-DA-PONTE, Francisco Diego; BAUNE, Bernhard T.; RAMESAR, Raj; RASGON, Natalie; REININGHAUS, Eva Z.; RICHARDS, Jenny Gringer; RITTER, Philipp; RYBAKOWSKI, Janusz K.; DALLASPEZIA, Sara; SATHYAPUTRI, Leela; SCIPPA, Angela M.; SIMHANDL, Christian; SMITH, Daniel; SMITH, Jose; STACKHOUSE, Jr Paul W.; BALABAN, Ceylan; STEIN, Dan J.; STILWELL, Kellen; STREJILEVICH, Sergio; ZOMPO, Maria Del; SU, Kuan-Pin; SUBRAMANIAM, Mythily; SULAIMAN, Ahmad Hatim; SUOMINEN, Kirsi; TANRA, Andi J.BackgroundSunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin D has widespread effects on brain function in both developing and adult brains. However, many people live at latitudes (about > 40 N or S) that do not receive enough UVB in winter to produce vitamin D. This exploratory study investigated the association between the age of onset of bipolar I disorder and the threshold for UVB sufficient for vitamin D production in a large global sample.MethodsData for 6972 patients with bipolar I disorder were obtained at 75 collection sites in 41 countries in both hemispheres. The best model to assess the relation between the threshold for UVB sufficient for vitamin D production and age of onset included 1 or more months below the threshold, family history of mood disorders, and birth cohort. All coefficients estimated at P <= 0.001.ResultsThe 6972 patients had an onset in 582 locations in 70 countries, with a mean age of onset of 25.6 years. Of the onset locations, 34.0% had at least 1 month below the threshold for UVB sufficient for vitamin D production. The age of onset at locations with 1 or more months of less than or equal to the threshold for UVB was 1.66 years younger.ConclusionUVB and vitamin D may have an important influence on the development of bipolar disorder. Study limitations included a lack of data on patient vitamin D levels, lifestyles, or supplement use. More study of the impacts of UVB and vitamin D in bipolar disorder is needed to evaluate this supposition.