GABRIEL OKAWA BELIZARIO
Projetos de Pesquisa
Unidades Organizacionais
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
20 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 20
conferenceObject The impact of structured physical exercise on cognitive function of bipolar patients: A study protocol for a randomized controlled trial(2023) BELIZARIO, Gabriel; DUARTE, Cicera; NEVES, Lucas; MATHIAS, Karla; LAFER, Beny- Predominant polarity classification and associated clinical variables in bipolar disorder: A machine learning approach(2019) BELIZARIO, Gabriel Okawa; BORGES JUNIOR, Renato Gomes; SALVINI, Rogerio; LAFER, Beny; DIAS, Rodrigo da SilvaBackground: Bipolar disorder (BD) is a severe psychiatric disorder characterized by periodic episodes of manic and depressive symptomatology. Predominant polarity (PP) appears to be an important specifier of BD. The present study employed machine learning (ML) algorithms to accurately determine a patient ' s PP without the inclusion of number and polarity of past episodes, while exploring associations between PP and demographic and clinical variables. Methods: From a cohort of 148 BD patients, demographic and clinical variables were collected using a customized questionnaire and the SCID-CV. The algorithm employed was the Random-Forest method. The algorithm was programed to classify patients into either depressive or manic predominant polarities and to reveal which variables were associated to the specifier. Results: The algorithm attained an AUC ROC of 74.72% (95% CI = 72.29-77.15%) in classifying patients into either manic or depressive PP. The variables selected by the algorithm were: (1) age at first depressive episode; (2) number of hospitalizations; (3) BD Type II; (4) manic onset; (5) delusions; (6) psychotic features at onset; (7) tobacco addiction; (8) family history of BD; (9) hallucinations; and (10) comorbid anxiety disorders, (11) alcohol dependence, (12) eating disorders and (13) substance dependence. Limitations: The study is limited due to the small sample size, the inclusion of only self-reported and clinician-observed clinical variables and its cross-sectional design. Discussion: The results suggest that the ML approach could be effective in determining a patient ' s PP. Furthermore, although not previously reported, some variables, such as tobacco use and comorbid eating disorders, appear to be closely associated with PP.
conferenceObject Structured physical exercise in bipolar depression: A pilot study(2020) DUARTE, Cicera; BELIZARIO, Gabriel O.; MATHIAS, Karla; SILVA, Michele; ROBERTO, Paulo; GREVE, Julia; LAFER, Beny- Cognitive behavioral rehabilitation for bipolar disorder patients: A randomized controlled trial(2019) GOMES, Bernardo C.; ROCCA, Cristiana C.; BELIZARIO, Gabriel O.; FERNANDES, Francy de B. F.; VALOIS, Iolanda; OLMO, Giselle C.; FACHIN, Raquel V. P.; FARHAT, Luis C.; LAFER, BenyObjectives Bipolar disorder is frequently associated with cognitive impairment even during euthymia. Previous studies have reported significant impairments in functional and quality of life outcomes and a possible relationship between these variables and cognitive performance. Cognitive rehabilitation interventions have been proposed to address these outcomes but positive results are still scarce. The objective of the present study is to evaluate the efficacy of a new intervention developed to address both cognitive and functional impairment. Methods Thirty-nine individuals were included in this randomized controlled trial. All participants were evaluated by the Cambridge Neuropsychological Test Automated Battery (CANTAB) and completed functional and quality of life (QOL) scales. Patients were randomized to either treatment as usual (TAU) or Cognitive Behavior Rehabilitation (CBR), an add-on treatment delivered in 12 weekly group sessions. All individuals were revaluated after 12 weeks. Results A total of 39 bipolar type I or II patients were included in the analysis, 19 in the TAU group and 20 in the CBR condition. At the entrance of the study, both groups were statistically similar regarding clinical, socio-demographics and cognitive variables. After the end of the intervention, CBR individuals had significantly improved reaction time, visual memory and emotion recognition. In contrast, individuals in the CBR did not present a statistically change in functional and QOL scores after the 12-week intervention. Conclusions CBR intervention showed promising results in improving some of the commonly impaired cognitive domains in BD. A longer follow-up period may be necessary to detect changes in functional and QOL domains.
conferenceObject Cognitive profile of bipolar disorder patients: A 12-year prospective study(2019) WOSNES, C. J.; ROCCA, C. C.; BELIZARIO, G. O.; LAFER, B.; NUNES, P. V.conferenceObject Impaired social cognition in bipolar disorder: A meta-analysis of theory of mind in euthymic patients(2020) ROTENBERG, Luisa deSiqueira; BELIZARIO, Gabriel O.; BERALDI, Gabriel; LAFER, Beny- Memory training combined with 3D visuospatial stimulus improves cognitive performance in the elderly: pilot study(2020) ASSED, Mariana Medeiros; ROCCA, Cristiana Castanho de Almeida; GARCIA, Yolanda Maria; KHAFIF, Tatiana Cohab; BELIZARIO, Gabriel Okawa; TOSCHI-DIAS, Edgar; SERAFIM, Antonio de PáduaABSTRACT. Studies suggest that the engagement of aged participants in cognitive stimulation programs can reduce expected cognitive decline associated with age. Objective: To evaluate the effects of memory training (MT) associated with three-dimensional multiple object tracking (3D-MOT) NeuroTracker (NT) in the elderly. Methods: Forty-four participants (>60 years of age) were recruited and randomly distributed into two groups: experimental (EG; n=22) and comparative (CG; n=22). Both groups performed 12 one-hour MT sessions, twice a week, consisting of specific computerized stimuli associated with teaching of mnemonic strategies; 10 minutes of NT was part only of the EG’s sessions. In pre- and post-training periods, both groups were evaluated using a sociodemographic questionnaire, neuropsychological assessment, as well as a specific measure offered by NT. Results: Both groups benefited from the MT and reported more positive feelings regarding their memory and quality of life. However, the EG obtained better results in tests consistent with the strategies trained and which involved attentional resources, reaction time, visual processing speed, episodic, semantic, subjective and working memory as well as aspects of social cognition. Conclusions: This study showed that the combination of MT and 3D-MOT contributed for a better cognitive performance in the EG. Thus, the results of the present study encourage further research and the development of combined cognitive interventions for the elderly population with and without cognitive deficits.
conferenceObject The impact of cannabis use on the course of bipolar disorder: A 8-year longitudinal study(2023) ESPINDOLA, Fernanda; RAMALHO, Alana; BELIZARIO, Gabriel Okawa; LAFER, BenyconferenceObject Predominant polarity determination from a machine learning approach(2018) BELIZARIO, G.; BORGES JUNIOR, R.; SALVINI, R.; LAFER, B.; DIAS, R.conferenceObject Quality of life is associated with clinical outcome in BD: a longitudinal study(2018) SILVA, M.; BELIZARIO, G. O.; ABREU, L. N.; LAFER, B.