EDUARDO FERREIRA BORBA NETO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Clínica Médica, Faculdade de Medicina - Docente
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
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article 22 Citação(ões) na Scopus Dyslipidaemia in juvenile dermatomyositis: the role of disease activity(2013) KOZU, K. T.; SILVA, C. A.; BONFA, E.; SALLUM, A. M.; PEREIRA, R. M. R.; VIANA, V. S.; BORBA, E.; CAMPOS, L. M.Objective To evaluate the presence of dyslipidaemia in JDM and its possible risk factors. Methods Twenty-five JDM patients were compared to 25 healthy controls according to demographic data, body composition, fasting lipoproteins, glycaemia, insulin, antibodies and muscle enzymes. JDM scores were assessed: CMAS, MMT, DAS, MYOACT and MYTAX. Results Abnormal lipid profile was found in nine patients and four controls (36% vs. 16%, p=0.196). TDM patients demonstrated significant higher levels of triglycerides (TG) [80(31-340) vs. 61(19-182) mgldL, p=0.011 j and higher frequency of abnormal levels of high density lipoproteins (HDL) (28% vs. 4%, p=0.04) when compared to controls. JDM patients with dyslipidaemia demonstrated significant lower median of HDL levels 129(0-49) vs. 50(39-72) mgldL, p=0.0005, higher frequency of low HDL levels (77% vs. 0%, p=0.0001),.higher TG levels [128(31-340) vs. 69(46-138) mgldL, p=0.011), and also a higher frequency of increased levels of TG (44% vs. 0%, p=0.01), and TC (33% vs. 0%, p=0.03) when compared to those without this condition. Positive anti-LPL antibody was detected in just one JDM patient with abnormal lipid profile. JDM with dyslipidaemia had higher ESR (26 vs. I 4.5mmllsthour, p=0.006), CRP (2.1 vs. 0.4mgldL, p=0.01), DAS (6 vs. 2, p=0.008), MYOACT(0.13 vs. 0.01, p=0.012), MYTAX(0.06vs.0,p=0.018), and lower scores of CMAS (47 vs. 52, p=0.024) and MMT (78 vs. 80, p=0.001) compared to JDM without dyslipidaemia. Positive correlations were detected between TG levels and CRP (7-.19.697, p=0.001), DAS (r-0.610, p=0.001), MYOACT (r=0.661, p=0.001),114YTAX (r-0.511, p=0.008), and negative correlations with CMAS (r=-0.506, p=0.009) and MMT (r=-0.535, p=0.005). No differences were found between these groups regarding body composition, lipodystrophy, anti-LPL antibodies, and treatment except by higher frequency of cyclosporine current use in patients with dys.lipidaemia (33% vs. 0%, p=0.03). Conclusions Dyslipidaemia in JDM patients was characterised by increased levels of TG and low levels of HDL. Disease activity and cyclosporine use were the mainly factors associated to these abnormalities.bookPart Lúpus eritematoso sistêmico(2013) PASOTO, Sandra Gofinet; BORBA, Eduardo Ferreira- Impaired aerobic exercise capacity and cardiac autonomic control in primary antiphospholipid syndrome(2013) GARCIA, C. B.; PERANDINI, L. A.; SEGURO, L. P. C.; GUALANO, B.; ROSCHEL, H.; BONFA, E.; BORBA, E. F.; SA-PINTO, A. L.Primary antiphospholipid syndrome (PAPS) is associated with increased risk of cardiovascular disease and mortality. Aerobic capacity and cardiac autonomic control are also associated with these risks. The aim of our study was to assess aerobic capacity and cardiac autonomic control in PAPS patients. Thirteen women with PAPS and 13 healthy controls matched for age, gender, and body mass index were enrolled for the study. Both groups were sedentary and were not under chronotropic, antidepressants and hypolipemiant drugs. All subjects performed a treadmill-graded maximal exercise. Aerobic capacity was assessed by peak oxygen uptake (VO(2)peak), time at anaerobic ventilatory threshold (VAT) and respiratory compensation point (RCP) and time-to-exhaustion, whereas cardiac autonomic control was assessed by chronotropic reserve (CR) and heart rate recovery at the first and second minutes after graded exercise (HRR1min and HRR2min, respectively). All aerobic capacity indexes were reduced more in PAPS patients than in healthy subjects: VO(2)peak (30.2 +/- 4.7 vs 34.6 +/- 4.3ml.kg(-1).min(-1), p=0.021), time at VAT (3.0 +/- 1.5 vs 5.0 +/- 2.0min, p=0.016), time at RCP (6.5 +/- 2.0 vs 8.0 +/- 2.0min, p=0.050), time-to-exhaustion (8.5 +/- 2.0 vs 11.0 +/- 2.5min, p=0.010). HRR1min (22 +/- 9 vs 30 +/- 7 bpm, p=0.032) and HRR2min (33 +/- 9 vs 46 +/- 8bpm, p=0.002) were delayed in PAPS patients compared to healthy controls but CR was not significantly different (p=0.272). In conclusion, an impaired aerobic capacity and cardiac autonomic control was identified in PAPS.
- Increased arterial stiffness assessed by pulse wave velocity in Behcet's disease and its association with the lipid profile(2013) CALDAS, C. A. M.; BORBA, E. F.; BORTOLOTTO, L. A.; MEDEIROS, D. M.; BONFA, E.; GONCALVES, C. R.Objective To evaluate the structural and functional properties of vessels in Behcet's Disease (BD) using carotid-femoral pulse wave velocity (PWV) and an echo-tracking system. Methods BD patients without traditional cardiovascular risk factors were selected. All BD patients performed PWV and carotid ultrasound. BD patients were divided into groups based on the presence of systemic (vascular and/or ocular and/or central nervous system involvement) and vascular involvement. Healthy controls age- and sex-matched with the same exclusion criteria were selected. Results A total of 23 BD patients (mean age 35.0 +/- 7.6years) had significantly higher PWV levels compared with controls (8.48 +/- 1.14 vs. 7.53 +/- 1.40m/s, P=0.017). Intima-media thickness (594.87 +/- 138.61 vs. 561.08 +/- 134.26m, P=0.371), diastolic diameter (6383.78 +/- 960.49 vs. 6447.65 +/- 1159.73m, P=0.840), distension (401.95 +/- 117.72 vs. 337.91 +/- 175.36m, P=0.225) and relative distension (6.26 +/- 2.83 vs. 5.42 +/- 2.46m, P=0.293) were similar in both groups. The systemic disease group had significantly higher levels of PWV (8.79 +/- 1.21 vs. 7.88 +/- 0.72m/s, P=0.036) compared to those with exclusive mucocutaneous manifestations. BD patients with vascular involvement had similar PWV and echo-tracking parameters compared to those without vascular involvement (0.05), but had higher total and LDL cholesterol levels (P=0.019 and P=0.012, respectively). The multivariate linear regression analysis identified triglycerides as the most important factor in increasing PWV levels (P=0.001) in BD. Conclusions PWV is more useful than carotid ultrasound in detecting structural and functional vascular damage in BD and emphasizes the role of the disease itself in promoting these alterations. Our findings also reinforce the need for rigorous control of all risk factors in BD, particularly lipoproteins.
- Anti-ribosomal P protein: a novel antibody in autoimmune hepatitis(2013) CALICH, Ana L.; VIANA, Vilma S. T.; CANCADO, Eduardo; TUSTUMI, Francisco; TERRABUIO, Debora R. B.; LEON, Elaine P.; SILVA, Clovis A.; BORBA, Eduardo F.; BONFA, EloisaBackground Autoantibodies to ribosomal P proteins (anti-rib P) are specific serological markers for systemic lupus erythematosus (SLE) and are associated with liver involvement in this disease. The similarity in autoimmune background between autoimmune hepatitis (AIH) and SLE-associated hepatitis raises the possibility that anti-rib P antibodies might also have relevance in AIH. Aims To evaluate the frequency and clinical significance of anti-rib P antibodies in a large AIH cohort. Methods Sera obtained at diagnosis of 96 AIH patients and of 82 healthy controls were tested for IgG anti-ribosomal P protein by ELISA. All of the sera were also screened for other lupus-specific autoantibodies, three patients with the presence of anti-dsDNA (n=1) and anti-Sm (n=2) were excluded. Results Moderate to high titres (>40U) of anti-rib P antibody were found in 9.7% (9/93) of the AIH patients and none of the controls (P=0.003). At presentation, AIH patients with and without anti-rib P antibodies had similar demographic/clinical features, including the frequency of cirrhosis (44.4 vs. 28.5%, P=0.44), hepatic laboratorial findings (0.05). Importantly, at the final observation (follow-up period 10.2 +/- 4.9years), the AIH patients with anti-rib P had a significantly higher frequency of cirrhosis compared with the negative group (100 vs. 60%, P=0.04). Conclusion The novel demonstration of anti-rib P in AIH patients without clinical or laboratory evidence of SLE suggests a common underlying mechanism targeting the liver in these two diseases. In addition, this antibody appears to predict the patients with worse AIH prognoses.
bookPart Emergências Reumatológicas Sistêmicas e Vasculites no Pronto-Socorro(2013) PROKOPOWITSCH, Aleksander Snioka; KURUMA, Kátia Akemi Miyazato; BORBA NETO, Eduardo FerreiraconferenceObject The Influence Of Socioeconomic and Race In Damage Score In Patients With Systemic Lupus Erythematosus(2013) TEIXEIRA, Roberto; BORBA, Eduardo F.; SR., Georges Christopoulos; SATO, EmiliabookPart Emergências reumatológicas sistêmicas e vasculites no pronto-socorro(2013) PROKOPOWITSCH, Aleksander Snioka; KURUMA, Kátia Akemi Miyazato; BORBA NETO, Eduardo Ferreira- Clinical and immunological features of 888 Brazilian systemic lupus patients from a monocentric cohort: comparison with other populations(2013) BORBA, E. F.; ARAUJO, D. B.; BONFA, E.; SHINJO, S. K.Epidemiological studies with systemic lupus erythematosus (SLE) patients have been reported worldwide but, until now, a large evaluation had not been performed in Brazil. Therefore, we determined the clinical and immunological features of 888 SLE patients followed at our service from 2008 to 2012. The mean age at SLE onset and the mean disease duration were 29.9 +/- 9.5 years old and 14.5 +/- 8.4 years, respectively. A predominance of female gender (91.9%) and Caucasian ethnicity (69.9%) were observed. Cumulative mucocutaneous manifestations (90.7%) were most commonly identified (malar rash (83.2%), photosensitivity (76.9%)) followed by articular (87.4%), hematological (44.0%) and renal (36.9%) involvements. Antinuclear antibody was detected in all patients, followed by anti-dsDNA (35.1%), anti-Sm (21.8%) and anti-ribosomal P protein antibodies (19.8%). Additional comparison of clinical and laboratory features between genders revealed that malar rash was observed more in female SLE patients (84.5% vs. 69.4%, p = 0.001). Male lupus patients presented a higher frequency of anti-dsDNA (45.8% vs. 34.2%, p = 0.047) and a trend of more nephritis (47.2% vs. 36.0%, p = 0.059). In conclusion, we identified a high prevalence of mucocutaneous manifestations in this Brazilian SLE cohort compared to other countries, mainly malar rash that was most commonly observed in female patients. Anti-dsDNA and other specific SLE autoantibodies were also identified in a higher frequency, predominantly in the male gender.
conferenceObject Inactive Systemic Lupus Erythematosus: Cytokines and Soluble Tumor Necrosis Factor Receptors Response To Moderate/Intense Exercise(2013) PERANDINI, Luiz A.; SALES-DE-OLIVEIRA, Diego; MELLO, Suzana B. V.; CAMARA, Niels O.; LIMA, Fernanda R.; BORBA, Eduardo F.; BONFA, Eloisa; SA-PINTO, Ana Lucia; ROSCHEL, Hamilton; GUALANO, Bruno