EDER CARLOS ROCHA QUINTAO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Clínica Médica, Faculdade de Medicina - Docente
LIM/10 - Laboratório de Lípides, Hospital das Clínicas, Faculdade de Medicina
LIM/10 - Laboratório de Lípides, Hospital das Clínicas, Faculdade de Medicina
12 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 12
- Metabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects(2013) LEANCA, Camila C.; NUNES, Valeria S.; PANZOLDO, Natalia B.; ZAGO, Vanessa S.; PARRA, Eliane S.; CAZITA, Patricia M.; JAUHIAINEN, Matti; PASSARELLI, Marisa; NAKANDAKARE, Edna R.; FARIA, Eliana C. de; QUINTAO, Eder C. R.Background: We have searched if plasma high density lipoprotein-cholesterol (HDL-C) concentration interferes simultaneously with whole-body cholesterol metabolism and insulin sensitivity in normal weight healthy adult subjects. Methods: We have measured the activities of several plasma components that are critically influenced by insulin and that control lipoprotein metabolism in subjects with low and high HDL-C concentrations. These parameters included cholesteryl ester transfer protein (CETP), phospholipid transfer protein (PLTP), lecithin cholesterol acyl transferase (LCAT), post-heparin lipoprotein lipase (LPL), hepatic lipase (HL), pre-beta-1HDL, and plasma sterol markers of cholesterol synthesis and intestinal absorption. Results: In the high-HDL-C group, we found lower plasma concentrations of triglycerides, alanine aminotransferase, insulin, HOMA-IR index, activities of LCAT and HL compared with the low HDL-C group; additionally, we found higher activity of LPL and pre-beta-1HDL concentration in the high-HDL-C group. There were no differences in the plasma CETP and PLTP activities. Conclusions: These findings indicate that in healthy hyperalphalipoproteinemia subjects, several parameters that control the metabolism of plasma cholesterol and lipoproteins are related to a higher degree of insulin sensitivity.
conferenceObject LIPOPROTEINS AND LIPID METABOLISM: HDL. AEROBIC EXERCISE TRAINING DOES NOT SYSTEMATICALLY AFFECT MACROPHAGE GENE EXPRESSION INVOLVED IN REVERSE CHOLESTEROL TRANSPORT AND CHOLESTEROL EFFLUX IN CETP TRANSGENIC MICE(2016) PINTO, P. R.; SILVA, K. S.; GOMES, D. J.; MACHADO-LIMA, A.; IBORRA, R. T.; FERREIRA, G. S.; QUINTAO, E. C. R.; NAKANDAKARE, E. R.; MACHADO, U. F.; CORREA-GIANNELLA, M. L. C.; CATANOZI, S.; PASSARELLI, M.conferenceObject CHOLESTEROL CONTENT AND SYNTHESIS IN THE BRAIN OF APOE KNOCKOUT MICE(2018) NUNES, V. Sutti; CAZITA, P. Miralda; CATANOZI, S.; NAKANDAKARE, E. R.; QUINTAO, E. C. R.conferenceObject Plasma 27-hydroxycholesterol/cholesterol Ratio is Increased in Low High Density Lipoprotein-Cholesterol Healthy Subjects(2012) NUNES, Valeria S.; LEANCA, Camila C.; PANZOLDO, Natalia B.; PARRA, Eliane; ZAGO, Vanessa; CAZITA, Patricia M.; NAKANDAKARE, Edna R.; FARIA, Eliana C. de; QUINTAO, Eder C.- Letter by Quintao and Cazita Regarding Article, ""Inhibition of Cholesteryl Ester Transfer Protein Preserves High-Density Lipoprotein Cholesterol and Improves Survival in Sepsis""(2021) QUINTAO, Eder C. R.; CAZITA, Patricia M.
- Does plasma HDL-C concentration interact with whole-body cholesterol metabolism?(2013) LEANCA, C. C.; NUNES, V. S.; NAKANDAKARE, E. R.; FARIA, E. C. de; QUINTAO, E. C. R.This review examines the interactions between plasma high density lipoprotein (HDL) metabolism and whole-body cholesterol economy. More specifically, this review addresses three questions: 1) does plasma HDL-C concentration correlate with the parameters of whole-body cholesterol metabolism? 2) Do variations in cholesterol metabolism interfere with plasma HDL-C concentrations? 3) Are the markers of cholesterol synthesis and intestinal absorption specifically under the control of plasma HDL? The following answers were provided to each question, respectively: 1) plasma HDL influences whole-body cholesterol synthesis rate but the evidence that HDL modifies the total amount of cholesterol absorbed by the intestine is not clearly supported by present investigations; 2) there are suggestions that changes in whole body cholesterol metabolism rates do not interfere with plasma HDL-C concentrations; 3) markers of cholesterol synthesis and absorption may specifically be controlled by plasma HDL-C concentrations regarding the genetic causes of extremely low HDL-C concentrations, although within the general population plasma HDL-C concentration is likely ascribed to insulin resistance or diabetes mellitus.
conferenceObject LOW-SALT DIET INDUCES ATHEROSCLEROSIS INDEPENDENT OF LOWERING BLOOD PRESSURE IN HYPERTENSIVE MICE(2016) CATANOZI, S.; FUSCO, F.; GOMES, D.; BISPO, K.; TOLEDO, V.; BARBEIRO, D.; CAPELOZZI, V.; FURUKAWA, L.; VELOSA, A. P.; TEODORO, W.; HEIMANN, J.; QUINTAO, E.; PASSARELLI, M.; NAKANDAKARE, E.- ASSOCIATIONS BETWEEN CAROTID INTIMA-MEDIA THICKNESS AND PHYSICOCHEMICAL PROPERTIES OF HIGH-DENSITY LIPOPROTEIN (HDL) PARTICLES(2017) ZAGO, Vanessa H. S.; ALEXANDRE, Fernanda; SCHERRER, Daniel Z.; PANZOLDO, Natalia B.; BARACAT, Jamal; GOMES, Erica I. L.; REBOLLA, Vanessa M.; QUINTAO, Eder C. R.; FARIA, Eliana C. De
- Effects of Atorvastatin and T-786C Polymorphism of eNOS Gene on Plasma Metabolic Lipid Parameters(2013) ZAGO, Vanessa Helena de Souza; SANTOS, Jose Eduardo Tanus dos; DANELON, Mirian Regina Gardin; SILVA, Roger Marcelo Mesquita da; PANZOLDO, Natalia Baratella; PARRA, Eliane Soler; ALEXANDRE, Fernanda; VIRGINIO, Vitor Wilson de Moura; QUINTAO, Eder Carlos Rocha; FARIA, Eliana Cotta deBackground: Endothelial nitric oxide synthase (eNOS) activity may be modulated by high-density lipoprotein cholesterol (HDL-C), statins or polymorphisms, such as the T-786C of eNOS. Objective: This study aimed at evaluating if the T-786C polymorphism is associated with changes of atorvastatin effects on the lipid profile, on the concentrations of metabolites of nitric oxide (NO) and of high sensitivity C-reactive protein (hsCRP). Methods: Thirty male volunteers, asymptomatic, aged between 18 and 56 years were genotyped and classified according to absence (TT, n = 15) or presence (CC, n = 15) of the polymorphism. They were randomly selected for the use of placebo or atorvastatin (10 mg/day/14 days). After each treatment lipids, lipoproteins, HDL2 and HDL3 composition, cholesteryl ester transfer protein (CETP) activity, metabolites of NO and hsCRP were evaluated. Results: The comparisons between genotypes after placebo showed an increase in CETP activity in a polymorphism-dependent way (TT, 12 +/- 7; CC, 22 +/- 12; p <= 0.05). The interaction analyses between treatments indicated that atorvastatin has an effect on cholesterol, LDL, nitrite and lipid-protein ratios (HDL2 and HDL3) (p <= 0.001) in both genotypes. Interestingly, we observed genotype/drug interactions on CETP (p <= 0.07) and lipoprotein (a) (Lp(a)) (p <= 0.056), leading to a borderline decrease in CETP, but with no effect on Lp(a). HsCRP showed no alteration. Conclusion: These results suggest that statin treatment may be relevant for primary prevention of atherosclerosis in patients with the T-786C polymorphism of eNOS, considering the effects on lipid metabolism. (Arq Bras Cardiol. 2013;100(1):14-20)
conferenceObject BONE MARROW DERIVED MACROPHAGES FROM HUMAN CETP TRANSGENIC MICE EXHIBIT REDUCED PHENOTYPIC POLARIZATION TO M1.(2021) SANTANA, K. G.; DANTAS, F. E.; SOUZA, C. N. De; DOMINGUEZ, O.; QUINTAO, E.; CAMARA, N. O. Saraiva; RAMALHO, T.; CAZITA, P. M.